| 06 Sep 98 | r01        | Los Angeles ChargersLos Angeles C | 16 - 14 | Buffalo BillsBuffalo Bills |
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| 13 Sep 98 | r02        | Miami DolphinsMiami Dolphin | 13 - 7 | Buffalo BillsBuffalo Bills |
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| 20 Sep 98 | r03        | Buffalo BillsBuffalo Bills | 33 - 34 | Los Angeles RamsLos Angeles R |
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| 04 Oct 98 | r05        | Buffalo BillsBuffalo Bills | 26 - 21 | San Francisco 49ersSan Francisco |
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| 11 Oct 98 | r06        | Indianapolis ColtsIndianapolis | 24 - 31 | Buffalo BillsBuffalo Bills |
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| 18 Oct 98 | r07        | Buffalo BillsBuffalo Bills | 17 - 16 | Jacksonville JaguarsJacksonville |
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| 26 Oct 98 | r08        | Carolina PanthersCarolina Pant | 14 - 30 | Buffalo BillsBuffalo Bills |
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| 01 Nov 98 | r09        | Buffalo BillsBuffalo Bills | 30 - 24 | Miami DolphinsMiami Dolphin |
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| 08 Nov 98 | r10        | New York JetsNew York Jets | 34 - 12 | Buffalo BillsBuffalo Bills |
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| 15 Nov 98 | r11        | Buffalo BillsBuffalo Bills | 13 - 10 | New England PatriotsNew England P |
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| 22 Nov 98 | r12        | Buffalo BillsBuffalo Bills | 34 - 11 | Indianapolis ColtsIndianapolis |
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| 29 Nov 98 | r13        | New England PatriotsNew England P | 25 - 21 | Buffalo BillsBuffalo Bills |
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| 06 Dec 98 | r14        | Cincinnati BengalsCincinnati Be | 20 - 33 | Buffalo BillsBuffalo Bills |
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| 13 Dec 98 | r15        | Buffalo BillsBuffalo Bills | 44 - 21 | Las Vegas RaidersLas Vegas Rai |
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| 19 Dec 98 | r16        | Buffalo BillsBuffalo Bills | 10 - 17 | New York JetsNew York Jets |
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| 27 Dec 98 | r17        | New Orleans SaintsNew Orleans S | 33 - 45 | Buffalo BillsBuffalo Bills |
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| 02 Jan 99 | Playoff        | Miami DolphinsMiami Dolphin | 24 - 17 | Buffalo BillsBuffalo Bills |