| 31 Aug 97 | r01        | Buffalo BillsBuffalo Bills | 13 - 34 | Minnesota VikingsMinnesota Vik |
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| 07 Sep 97 | r02        | New York JetsNew York Jets | 22 - 28 | Buffalo BillsBuffalo Bills |
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| 14 Sep 97 | r03        | Kansas City ChiefsKansas City C | 22 - 16 | Buffalo BillsBuffalo Bills |
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| 21 Sep 97 | r04        | Buffalo BillsBuffalo Bills | 37 - 35 | Indianapolis ColtsIndianapolis |
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| 05 Oct 97 | r06        | Buffalo BillsBuffalo Bills | 22 - 13 | Detroit LionsDetroit Lions |
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| 12 Oct 97 | r07        | New England PatriotsNew England P | 33 - 6 | Buffalo BillsBuffalo Bills |
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| 21 Oct 97 | r08        | Indianapolis ColtsIndianapolis | 6 - 9 | Buffalo BillsBuffalo Bills |
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| 26 Oct 97 | r09        | Buffalo BillsBuffalo Bills | 20 - 23 | Denver BroncosDenver Bronco |
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| 02 Nov 97 | r10        | Buffalo BillsBuffalo Bills | 9 - 6 | Miami DolphinsMiami Dolphin |
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| 09 Nov 97 | r11        | Buffalo BillsBuffalo Bills | 10 - 31 | New England PatriotsNew England P |
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| 18 Nov 97 | r12        | Miami DolphinsMiami Dolphin | 30 - 13 | Buffalo BillsBuffalo Bills |
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| 23 Nov 97 | r13        | Tennessee TitansTennessee Tit | 31 - 14 | Buffalo BillsBuffalo Bills |
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| 30 Nov 97 | r14        | Buffalo BillsBuffalo Bills | 20 - 10 | New York JetsNew York Jets |
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| 07 Dec 97 | r15        | Chicago BearsChicago Bears | 20 - 3 | Buffalo BillsBuffalo Bills |
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| 14 Dec 97 | r16        | Buffalo BillsBuffalo Bills | 14 - 20 | Jacksonville JaguarsJacksonville |
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| 20 Dec 97 | r17        | Green Bay PackersGreen Bay Pac | 31 - 21 | Buffalo BillsBuffalo Bills |