| 03 Sep 91 | r01        | New York GiantsNew York Gian | 16 - 14 | San Francisco 49ersSan Francisco |
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| 08 Sep 91 | r02        | San Francisco 49ersSan Francisco | 34 - 14 | Los Angeles ChargersLos Angeles C |
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| 15 Sep 91 | r03        | Minnesota VikingsMinnesota Vik | 17 - 14 | San Francisco 49ersSan Francisco |
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| 22 Sep 91 | r04        | San Francisco 49ersSan Francisco | 27 - 10 | Los Angeles RamsLos Angeles R |
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| 29 Sep 91 | r05        | Las Vegas RaidersLas Vegas Rai | 12 - 6 | San Francisco 49ersSan Francisco |
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| 13 Oct 91 | r07        | San Francisco 49ersSan Francisco | 34 - 39 | Atlanta FalconsAtlanta Falco |
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| 20 Oct 91 | r08        | San Francisco 49ersSan Francisco | 35 - 3 | Detroit LionsDetroit Lions |
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| 27 Oct 91 | r09        | Philadelphia EaglesPhiladelphia | 7 - 23 | San Francisco 49ersSan Francisco |
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| 03 Nov 91 | r10        | Atlanta FalconsAtlanta Falco | 17 - 14 | San Francisco 49ersSan Francisco |
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| 10 Nov 91 | r11        | New Orleans SaintsNew Orleans S | 10 - 3 | San Francisco 49ersSan Francisco |
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| 17 Nov 91 | r12        | San Francisco 49ersSan Francisco | 14 - 10 | Arizona CardinalsArizona Cardi |
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| 26 Nov 91 | r13        | Los Angeles RamsLos Angeles R | 10 - 33 | San Francisco 49ersSan Francisco |
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| 01 Dec 91 | r14        | San Francisco 49ersSan Francisco | 38 - 24 | New Orleans SaintsNew Orleans S |
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| 08 Dec 91 | r15        | Seattle SeahawksSeattle Seaha | 22 - 24 | San Francisco 49ersSan Francisco |
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| 14 Dec 91 | r16        | San Francisco 49ersSan Francisco | 28 - 14 | Kansas City ChiefsKansas City C |
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| 24 Dec 91 | r17        | San Francisco 49ersSan Francisco | 52 - 14 | Chicago BearsChicago Bears |