| 01 Sep 91 | r01        | Indianapolis ColtsIndianapolis | 7 - 16 | New England PatriotsNew England P |
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| 08 Sep 91 | r02        | Miami DolphinsMiami Dolphin | 17 - 6 | Indianapolis ColtsIndianapolis |
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| 15 Sep 91 | r03        | Las Vegas RaidersLas Vegas Rai | 16 - 0 | Indianapolis ColtsIndianapolis |
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| 22 Sep 91 | r04        | Indianapolis ColtsIndianapolis | 24 - 33 | Detroit LionsDetroit Lions |
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| 29 Sep 91 | r05        | Seattle SeahawksSeattle Seaha | 31 - 3 | Indianapolis ColtsIndianapolis |
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| 06 Oct 91 | r06        | Indianapolis ColtsIndianapolis | 3 - 21 | Pittsburgh SteelersPittsburgh St |
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| 13 Oct 91 | r07        | Buffalo BillsBuffalo Bills | 42 - 6 | Indianapolis ColtsIndianapolis |
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| 20 Oct 91 | r08        | Indianapolis ColtsIndianapolis | 6 - 17 | New York JetsNew York Jets |
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| 03 Nov 91 | r10        | Indianapolis ColtsIndianapolis | 6 - 10 | Miami DolphinsMiami Dolphin |
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| 10 Nov 91 | r11        | New York JetsNew York Jets | 27 - 28 | Indianapolis ColtsIndianapolis |
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| 17 Nov 91 | r12        | Indianapolis ColtsIndianapolis | 17 - 31 | Chicago BearsChicago Bears |
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| 24 Nov 91 | r13        | Green Bay PackersGreen Bay Pac | 14 - 10 | Indianapolis ColtsIndianapolis |
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| 01 Dec 91 | r14        | Indianapolis ColtsIndianapolis | 0 - 31 | Cleveland BrownsCleveland Bro |
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| 08 Dec 91 | r15        | New England PatriotsNew England P | 23 - 17 | Indianapolis ColtsIndianapolis |
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| 16 Dec 91 | r16        | Indianapolis ColtsIndianapolis | 7 - 35 | Buffalo BillsBuffalo Bills |
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| 22 Dec 91 | r17        | Tampa Bay BuccaneersTampa Bay Buc | 17 - 3 | Indianapolis ColtsIndianapolis |