| 11 Sep 90 | r01        | New Orleans SaintsNew Orleans S | 12 - 13 | San Francisco 49ersSan Francisco |
| |
| 16 Sep 90 | r02        | San Francisco 49ersSan Francisco | 26 - 13 | Washington CommandersWashington Co |
| |
| 23 Sep 90 | r03        | San Francisco 49ersSan Francisco | 19 - 13 | Atlanta FalconsAtlanta Falco |
| |
| 07 Oct 90 | r05        | Tennessee TitansTennessee Tit | 21 - 24 | San Francisco 49ersSan Francisco |
| |
| 14 Oct 90 | r06        | Atlanta FalconsAtlanta Falco | 35 - 45 | San Francisco 49ersSan Francisco |
| |
| 21 Oct 90 | r07        | San Francisco 49ersSan Francisco | 27 - 7 | Pittsburgh SteelersPittsburgh St |
| |
| 28 Oct 90 | r08        | San Francisco 49ersSan Francisco | 20 - 17 | Cleveland BrownsCleveland Bro |
| |
| 04 Nov 90 | r09        | Green Bay PackersGreen Bay Pac | 20 - 24 | San Francisco 49ersSan Francisco |
| |
| 12 Nov 90 | r10        | Dallas CowboysDallas Cowboy | 6 - 24 | San Francisco 49ersSan Francisco |
| |
| 18 Nov 90 | r11        | San Francisco 49ersSan Francisco | 31 - 7 | Tampa Bay BuccaneersTampa Bay Buc |
| |
| 25 Nov 90 | r12        | San Francisco 49ersSan Francisco | 17 - 28 | Los Angeles RamsLos Angeles R |
| |
| 04 Dec 90 | r13        | San Francisco 49ersSan Francisco | 7 - 3 | New York GiantsNew York Gian |
| |
| 09 Dec 90 | r14        | Cincinnati BengalsCincinnati Be | 17 - 20 | San Francisco 49ersSan Francisco |
| |
| 18 Dec 90 | r15        | Los Angeles RamsLos Angeles R | 10 - 26 | San Francisco 49ersSan Francisco |
| |
| 23 Dec 90 | r16        | San Francisco 49ersSan Francisco | 10 - 13 | New Orleans SaintsNew Orleans S |
| |
| 30 Dec 90 | r17        | Minnesota VikingsMinnesota Vik | 17 - 20 | San Francisco 49ersSan Francisco |
| |
| 12 Jan 91 | QF        | San Francisco 49ersSan Francisco | 28 - 10 | Washington CommandersWashington Co |
| |
| 20 Jan 91 | SF        | San Francisco 49ersSan Francisco | 13 - 15 | New York GiantsNew York Gian |