| 09 Sep 90 | r01        | Detroit LionsDetroit Lions | 21 - 38 | Tampa Bay BuccaneersTampa Bay Buc |
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| 16 Sep 90 | r02        | Detroit LionsDetroit Lions | 21 - 14 | Atlanta FalconsAtlanta Falco |
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| 24 Sep 90 | r03        | Tampa Bay BuccaneersTampa Bay Buc | 23 - 20 | Detroit LionsDetroit Lions |
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| 30 Sep 90 | r04        | Detroit LionsDetroit Lions | 21 - 24 | Green Bay PackersGreen Bay Pac |
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| 07 Oct 90 | r05        | Minnesota VikingsMinnesota Vik | 27 - 34 | Detroit LionsDetroit Lions |
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| 14 Oct 90 | r06        | Kansas City ChiefsKansas City C | 43 - 24 | Detroit LionsDetroit Lions |
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| 28 Oct 90 | r08        | New Orleans SaintsNew Orleans S | 10 - 27 | Detroit LionsDetroit Lions |
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| 04 Nov 90 | r09        | Detroit LionsDetroit Lions | 38 - 41 | Washington CommandersWashington Co |
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| 11 Nov 90 | r10        | Detroit LionsDetroit Lions | 7 - 17 | Minnesota VikingsMinnesota Vik |
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| 18 Nov 90 | r11        | New York GiantsNew York Gian | 20 - 0 | Detroit LionsDetroit Lions |
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| 22 Nov 90 | r12        | Detroit LionsDetroit Lions | 40 - 27 | Denver BroncosDenver Bronco |
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| 02 Dec 90 | r13        | Chicago BearsChicago Bears | 23 - 17 | Detroit LionsDetroit Lions |
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| 11 Dec 90 | r14        | Detroit LionsDetroit Lions | 31 - 38 | Las Vegas RaidersLas Vegas Rai |
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| 17 Dec 90 | r15        | Detroit LionsDetroit Lions | 38 - 21 | Chicago BearsChicago Bears |
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| 22 Dec 90 | r16        | Green Bay PackersGreen Bay Pac | 17 - 24 | Detroit LionsDetroit Lions |
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| 30 Dec 90 | r17        | Seattle SeahawksSeattle Seaha | 30 - 10 | Detroit LionsDetroit Lions |