| 10 Sep 89 | r01        | Miami DolphinsMiami Dolphin | 24 - 27 | Buffalo BillsBuffalo Bills |
| |
| 19 Sep 89 | r02        | Buffalo BillsBuffalo Bills | 14 - 28 | Denver BroncosDenver Bronco |
| |
| 24 Sep 89 | r03        | Tennessee TitansTennessee Tit | 41 - 47 | Buffalo BillsBuffalo Bills |
| |
| 01 Oct 89 | r04        | Buffalo BillsBuffalo Bills | 31 - 10 | New England PatriotsNew England P |
| |
| 08 Oct 89 | r05        | Indianapolis ColtsIndianapolis | 37 - 14 | Buffalo BillsBuffalo Bills |
| |
| 17 Oct 89 | r06        | Buffalo BillsBuffalo Bills | 23 - 20 | Los Angeles RamsLos Angeles R |
| |
| 22 Oct 89 | r07        | Buffalo BillsBuffalo Bills | 34 - 3 | New York JetsNew York Jets |
| |
| 29 Oct 89 | r08        | Buffalo BillsBuffalo Bills | 31 - 17 | Miami DolphinsMiami Dolphin |
| |
| 05 Nov 89 | r09        | Atlanta FalconsAtlanta Falco | 30 - 28 | Buffalo BillsBuffalo Bills |
| |
| 12 Nov 89 | r10        | Buffalo BillsBuffalo Bills | 30 - 7 | Indianapolis ColtsIndianapolis |
| 19 Nov 89 | r10        | New England PatriotsNew England P | 33 - 24 | Buffalo BillsBuffalo Bills |
| |
| 26 Nov 89 | r12        | Buffalo BillsBuffalo Bills | 24 - 7 | Cincinnati BengalsCincinnati Be |
| |
| 05 Dec 89 | r13        | Seattle SeahawksSeattle Seaha | 17 - 16 | Buffalo BillsBuffalo Bills |
| |
| 10 Dec 89 | r14        | Buffalo BillsBuffalo Bills | 19 - 22 | New Orleans SaintsNew Orleans S |
| |
| 17 Dec 89 | r15        | San Francisco 49ersSan Francisco | 21 - 10 | Buffalo BillsBuffalo Bills |
| |
| 23 Dec 89 | r16        | New York JetsNew York Jets | 0 - 37 | Buffalo BillsBuffalo Bills |
| |
| 06 Jan 90 | QF        | Cleveland BrownsCleveland Bro | 34 - 30 | Buffalo BillsBuffalo Bills |