| 13 Sep 87 | r01        | Buffalo BillsBuffalo Bills | 28 - 31 | New York JetsNew York Jets |
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| 20 Sep 87 | r02        | Buffalo BillsBuffalo Bills | 34 - 30 | Tennessee TitansTennessee Tit |
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| 04 Oct 87 | r04        | Buffalo BillsBuffalo Bills | 6 - 47 | Indianapolis ColtsIndianapolis |
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| 11 Oct 87 | r05        | New England PatriotsNew England P | 14 - 7 | Buffalo BillsBuffalo Bills |
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| 18 Oct 87 | r06        | Buffalo BillsBuffalo Bills | 6 - 3 | New York GiantsNew York Gian |
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| 25 Oct 87 | r07        | Miami DolphinsMiami Dolphin | 31 - 34 | Buffalo BillsBuffalo Bills |
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| 01 Nov 87 | r08        | Buffalo BillsBuffalo Bills | 7 - 27 | Washington CommandersWashington Co |
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| 08 Nov 87 | r09        | Buffalo BillsBuffalo Bills | 21 - 14 | Denver BroncosDenver Bronco |
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| 15 Nov 87 | r10        | Cleveland BrownsCleveland Bro | 27 - 21 | Buffalo BillsBuffalo Bills |
| 22 Nov 87 | r10        | New York JetsNew York Jets | 14 - 17 | Buffalo BillsBuffalo Bills |
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| 29 Nov 87 | r12        | Buffalo BillsBuffalo Bills | 27 - 0 | Miami DolphinsMiami Dolphin |
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| 06 Dec 87 | r13        | Las Vegas RaidersLas Vegas Rai | 34 - 21 | Buffalo BillsBuffalo Bills |
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| 13 Dec 87 | r14        | Indianapolis ColtsIndianapolis | 3 - 27 | Buffalo BillsBuffalo Bills |
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| 20 Dec 87 | r15        | Buffalo BillsBuffalo Bills | 7 - 13 | New England PatriotsNew England P |
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| 27 Dec 87 | r16        | Philadelphia EaglesPhiladelphia | 17 - 7 | Buffalo BillsBuffalo Bills |