| 07 Sep 86 | r01        | Buffalo BillsBuffalo Bills | 24 - 28 | New York JetsNew York Jets |
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| 14 Sep 86 | r02        | Cincinnati BengalsCincinnati Be | 36 - 33 | Buffalo BillsBuffalo Bills |
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| 21 Sep 86 | r03        | Buffalo BillsBuffalo Bills | 17 - 10 | Arizona CardinalsArizona Cardi |
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| 28 Sep 86 | r04        | Buffalo BillsBuffalo Bills | 17 - 20 | Kansas City ChiefsKansas City C |
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| 05 Oct 86 | r05        | New York JetsNew York Jets | 14 - 13 | Buffalo BillsBuffalo Bills |
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| 12 Oct 86 | r06        | Miami DolphinsMiami Dolphin | 27 - 14 | Buffalo BillsBuffalo Bills |
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| 19 Oct 86 | r07        | Buffalo BillsBuffalo Bills | 24 - 13 | Indianapolis ColtsIndianapolis |
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| 26 Oct 86 | r08        | Buffalo BillsBuffalo Bills | 3 - 23 | New England PatriotsNew England P |
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| 02 Nov 86 | r09        | Tampa Bay BuccaneersTampa Bay Buc | 34 - 28 | Buffalo BillsBuffalo Bills |
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| 09 Nov 86 | r10        | Buffalo BillsBuffalo Bills | 16 - 12 | Pittsburgh SteelersPittsburgh St |
| 16 Nov 86 | r10        | Buffalo BillsBuffalo Bills | 24 - 34 | Miami DolphinsMiami Dolphin |
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| 23 Nov 86 | r12        | New England PatriotsNew England P | 22 - 19 | Buffalo BillsBuffalo Bills |
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| 30 Nov 86 | r13        | Kansas City ChiefsKansas City C | 14 - 17 | Buffalo BillsBuffalo Bills |
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| 07 Dec 86 | r14        | Buffalo BillsBuffalo Bills | 17 - 21 | Cleveland BrownsCleveland Bro |
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| 14 Dec 86 | r15        | Indianapolis ColtsIndianapolis | 24 - 14 | Buffalo BillsBuffalo Bills |
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| 21 Dec 86 | r16        | Tennessee TitansTennessee Tit | 16 - 7 | Buffalo BillsBuffalo Bills |