| 08 Sep 85 | r01        | Minnesota VikingsMinnesota Vik | 28 - 21 | San Francisco 49ersSan Francisco |
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| 15 Sep 85 | r02        | San Francisco 49ersSan Francisco | 35 - 16 | Atlanta FalconsAtlanta Falco |
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| 22 Sep 85 | r03        | Las Vegas RaidersLas Vegas Rai | 10 - 34 | San Francisco 49ersSan Francisco |
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| 29 Sep 85 | r04        | San Francisco 49ersSan Francisco | 17 - 20 | New Orleans SaintsNew Orleans S |
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| 06 Oct 85 | r05        | Atlanta FalconsAtlanta Falco | 17 - 38 | San Francisco 49ersSan Francisco |
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| 13 Oct 85 | r06        | San Francisco 49ersSan Francisco | 10 - 26 | Chicago BearsChicago Bears |
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| 20 Oct 85 | r07        | Detroit LionsDetroit Lions | 23 - 21 | San Francisco 49ersSan Francisco |
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| 27 Oct 85 | r08        | Los Angeles RamsLos Angeles R | 14 - 28 | San Francisco 49ersSan Francisco |
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| 03 Nov 85 | r09        | San Francisco 49ersSan Francisco | 24 - 13 | Philadelphia EaglesPhiladelphia |
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| 12 Nov 85 | r10        | Denver BroncosDenver Bronco | 17 - 16 | San Francisco 49ersSan Francisco |
| 17 Nov 85 | r10        | San Francisco 49ersSan Francisco | 31 - 3 | Kansas City ChiefsKansas City C |
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| 26 Nov 85 | r12        | San Francisco 49ersSan Francisco | 19 - 6 | Seattle SeahawksSeattle Seaha |
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| 01 Dec 85 | r13        | Washington CommandersWashington Co | 8 - 35 | San Francisco 49ersSan Francisco |
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| 10 Dec 85 | r14        | San Francisco 49ersSan Francisco | 20 - 27 | Los Angeles RamsLos Angeles R |
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| 15 Dec 85 | r15        | New Orleans SaintsNew Orleans S | 19 - 31 | San Francisco 49ersSan Francisco |
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| 22 Dec 85 | r16        | San Francisco 49ersSan Francisco | 31 - 16 | Dallas CowboysDallas Cowboy |
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| 29 Dec 85 | Playoff        | New York GiantsNew York Gian | 17 - 3 | San Francisco 49ersSan Francisco |