| 08 Sep 85 | r01        | Pittsburgh SteelersPittsburgh St | 45 - 3 | Indianapolis ColtsIndianapolis |
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| 15 Sep 85 | r02        | Miami DolphinsMiami Dolphin | 30 - 13 | Indianapolis ColtsIndianapolis |
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| 22 Sep 85 | r03        | Indianapolis ColtsIndianapolis | 14 - 6 | Detroit LionsDetroit Lions |
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| 29 Sep 85 | r04        | New York JetsNew York Jets | 25 - 20 | Indianapolis ColtsIndianapolis |
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| 06 Oct 85 | r05        | Indianapolis ColtsIndianapolis | 49 - 17 | Buffalo BillsBuffalo Bills |
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| 13 Oct 85 | r06        | Indianapolis ColtsIndianapolis | 10 - 15 | Denver BroncosDenver Bronco |
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| 20 Oct 85 | r07        | Buffalo BillsBuffalo Bills | 21 - 9 | Indianapolis ColtsIndianapolis |
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| 27 Oct 85 | r08        | Indianapolis ColtsIndianapolis | 37 - 10 | Green Bay PackersGreen Bay Pac |
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| 03 Nov 85 | r09        | Indianapolis ColtsIndianapolis | 17 - 35 | New York JetsNew York Jets |
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| 10 Nov 85 | r10        | New England PatriotsNew England P | 34 - 15 | Indianapolis ColtsIndianapolis |
| 17 Nov 85 | r10        | Indianapolis ColtsIndianapolis | 20 - 34 | Miami DolphinsMiami Dolphin |
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| 24 Nov 85 | r12        | Kansas City ChiefsKansas City C | 20 - 7 | Indianapolis ColtsIndianapolis |
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| 01 Dec 85 | r13        | Indianapolis ColtsIndianapolis | 31 - 38 | New England PatriotsNew England P |
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| 08 Dec 85 | r14        | Chicago BearsChicago Bears | 17 - 10 | Indianapolis ColtsIndianapolis |
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| 15 Dec 85 | r15        | Tampa Bay BuccaneersTampa Bay Buc | 23 - 31 | Indianapolis ColtsIndianapolis |
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| 22 Dec 85 | r16        | Indianapolis ColtsIndianapolis | 34 - 16 | Tennessee TitansTennessee Tit |