| 08 Sep 85 | r01        | Buffalo BillsBuffalo Bills | 9 - 14 | Los Angeles ChargersLos Angeles C |
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| 15 Sep 85 | r02        | New York JetsNew York Jets | 42 - 3 | Buffalo BillsBuffalo Bills |
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| 22 Sep 85 | r03        | Buffalo BillsBuffalo Bills | 14 - 17 | New England PatriotsNew England P |
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| 29 Sep 85 | r04        | Buffalo BillsBuffalo Bills | 20 - 27 | Minnesota VikingsMinnesota Vik |
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| 06 Oct 85 | r05        | Indianapolis ColtsIndianapolis | 49 - 17 | Buffalo BillsBuffalo Bills |
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| 13 Oct 85 | r06        | New England PatriotsNew England P | 14 - 3 | Buffalo BillsBuffalo Bills |
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| 20 Oct 85 | r07        | Buffalo BillsBuffalo Bills | 21 - 9 | Indianapolis ColtsIndianapolis |
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| 27 Oct 85 | r08        | Philadelphia EaglesPhiladelphia | 21 - 17 | Buffalo BillsBuffalo Bills |
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| 03 Nov 85 | r09        | Buffalo BillsBuffalo Bills | 17 - 23 | Cincinnati BengalsCincinnati Be |
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| 10 Nov 85 | r10        | Buffalo BillsBuffalo Bills | 20 - 0 | Tennessee TitansTennessee Tit |
| 17 Nov 85 | r10        | Cleveland BrownsCleveland Bro | 17 - 7 | Buffalo BillsBuffalo Bills |
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| 24 Nov 85 | r12        | Buffalo BillsBuffalo Bills | 14 - 23 | Miami DolphinsMiami Dolphin |
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| 01 Dec 85 | r13        | Los Angeles ChargersLos Angeles C | 40 - 7 | Buffalo BillsBuffalo Bills |
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| 08 Dec 85 | r14        | Buffalo BillsBuffalo Bills | 7 - 27 | New York JetsNew York Jets |
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| 15 Dec 85 | r15        | Pittsburgh SteelersPittsburgh St | 30 - 24 | Buffalo BillsBuffalo Bills |
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| 22 Dec 85 | r16        | Miami DolphinsMiami Dolphin | 28 - 0 | Buffalo BillsBuffalo Bills |