| 06 Sep 81 | r01        | Detroit LionsDetroit Lions | 24 - 17 | San Francisco 49ersSan Francisco |
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| 13 Sep 81 | r02        | San Francisco 49ersSan Francisco | 28 - 17 | Chicago BearsChicago Bears |
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| 20 Sep 81 | r03        | Atlanta FalconsAtlanta Falco | 34 - 17 | San Francisco 49ersSan Francisco |
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| 27 Sep 81 | r04        | San Francisco 49ersSan Francisco | 21 - 14 | New Orleans SaintsNew Orleans S |
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| 04 Oct 81 | r05        | Washington CommandersWashington Co | 17 - 30 | San Francisco 49ersSan Francisco |
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| 11 Oct 81 | r06        | San Francisco 49ersSan Francisco | 45 - 14 | Dallas CowboysDallas Cowboy |
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| 18 Oct 81 | r07        | Green Bay PackersGreen Bay Pac | 3 - 13 | San Francisco 49ersSan Francisco |
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| 25 Oct 81 | r08        | San Francisco 49ersSan Francisco | 20 - 17 | Los Angeles RamsLos Angeles R |
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| 01 Nov 81 | r09        | Pittsburgh SteelersPittsburgh St | 14 - 17 | San Francisco 49ersSan Francisco |
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| 08 Nov 81 | r10        | San Francisco 49ersSan Francisco | 17 - 14 | Atlanta FalconsAtlanta Falco |
| 15 Nov 81 | r10        | San Francisco 49ersSan Francisco | 12 - 15 | Cleveland BrownsCleveland Bro |
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| 22 Nov 81 | r12        | Los Angeles RamsLos Angeles R | 31 - 33 | San Francisco 49ersSan Francisco |
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| 29 Nov 81 | r13        | San Francisco 49ersSan Francisco | 17 - 10 | New York GiantsNew York Gian |
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| 06 Dec 81 | r14        | Cincinnati BengalsCincinnati Be | 3 - 21 | San Francisco 49ersSan Francisco |
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| 13 Dec 81 | r15        | San Francisco 49ersSan Francisco | 28 - 6 | Tennessee TitansTennessee Tit |
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| 20 Dec 81 | r16        | New Orleans SaintsNew Orleans S | 17 - 21 | San Francisco 49ersSan Francisco |
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| 03 Jan 82 | QF        | San Francisco 49ersSan Francisco | 38 - 24 | New York GiantsNew York Gian |
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| 10 Jan 82 | SF        | San Francisco 49ersSan Francisco | 28 - 27 | Dallas CowboysDallas Cowboy |
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| 24 Jan 82 | Final        | Cincinnati BengalsCincinnati Be | 21 - 26 | San Francisco 49ersSan Francisco |