| 06 Sep 81 | r01        | Arizona CardinalsArizona Cardi | 7 - 20 | Miami DolphinsMiami Dolphin |
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| 13 Sep 81 | r02        | Dallas CowboysDallas Cowboy | 30 - 17 | Arizona CardinalsArizona Cardi |
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| 20 Sep 81 | r03        | Arizona CardinalsArizona Cardi | 40 - 30 | Washington CommandersWashington Co |
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| 27 Sep 81 | r04        | Tampa Bay BuccaneersTampa Bay Buc | 20 - 10 | Arizona CardinalsArizona Cardi |
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| 04 Oct 81 | r05        | Arizona CardinalsArizona Cardi | 20 - 17 | Dallas CowboysDallas Cowboy |
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| 11 Oct 81 | r06        | New York GiantsNew York Gian | 34 - 14 | Arizona CardinalsArizona Cardi |
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| 18 Oct 81 | r07        | Atlanta FalconsAtlanta Falco | 41 - 20 | Arizona CardinalsArizona Cardi |
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| 25 Oct 81 | r08        | Arizona CardinalsArizona Cardi | 30 - 17 | Minnesota VikingsMinnesota Vik |
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| 01 Nov 81 | r09        | Washington CommandersWashington Co | 42 - 21 | Arizona CardinalsArizona Cardi |
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| 08 Nov 81 | r10        | Arizona CardinalsArizona Cardi | 10 - 52 | Philadelphia EaglesPhiladelphia |
| 15 Nov 81 | r10        | Arizona CardinalsArizona Cardi | 24 - 0 | Buffalo BillsBuffalo Bills |
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| 22 Nov 81 | r12        | Indianapolis ColtsIndianapolis | 24 - 35 | Arizona CardinalsArizona Cardi |
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| 29 Nov 81 | r13        | New England PatriotsNew England P | 20 - 27 | Arizona CardinalsArizona Cardi |
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| 06 Dec 81 | r14        | Arizona CardinalsArizona Cardi | 30 - 3 | New Orleans SaintsNew Orleans S |
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| 13 Dec 81 | r15        | Arizona CardinalsArizona Cardi | 10 - 20 | New York GiantsNew York Gian |
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| 20 Dec 81 | r16        | Philadelphia EaglesPhiladelphia | 38 - 0 | Arizona CardinalsArizona Cardi |