| 06 Sep 81 | r01        | Detroit LionsDetroit Lions | 24 - 17 | San Francisco 49ersSan Francisco |
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| 13 Sep 81 | r02        | Los Angeles ChargersLos Angeles C | 28 - 23 | Detroit LionsDetroit Lions |
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| 20 Sep 81 | r03        | Minnesota VikingsMinnesota Vik | 26 - 24 | Detroit LionsDetroit Lions |
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| 27 Sep 81 | r04        | Detroit LionsDetroit Lions | 16 - 0 | Las Vegas RaidersLas Vegas Rai |
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| 04 Oct 81 | r05        | Tampa Bay BuccaneersTampa Bay Buc | 28 - 10 | Detroit LionsDetroit Lions |
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| 11 Oct 81 | r06        | Denver BroncosDenver Bronco | 27 - 21 | Detroit LionsDetroit Lions |
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| 20 Oct 81 | r07        | Detroit LionsDetroit Lions | 48 - 17 | Chicago BearsChicago Bears |
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| 25 Oct 81 | r08        | Detroit LionsDetroit Lions | 31 - 27 | Green Bay PackersGreen Bay Pac |
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| 01 Nov 81 | r09        | Los Angeles RamsLos Angeles R | 20 - 13 | Detroit LionsDetroit Lions |
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| 08 Nov 81 | r10        | Washington CommandersWashington Co | 33 - 31 | Detroit LionsDetroit Lions |
| 15 Nov 81 | r10        | Detroit LionsDetroit Lions | 27 - 24 | Dallas CowboysDallas Cowboy |
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| 22 Nov 81 | r12        | Chicago BearsChicago Bears | 7 - 23 | Detroit LionsDetroit Lions |
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| 26 Nov 81 | r13        | Detroit LionsDetroit Lions | 27 - 10 | Kansas City ChiefsKansas City C |
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| 06 Dec 81 | r14        | Green Bay PackersGreen Bay Pac | 31 - 17 | Detroit LionsDetroit Lions |
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| 12 Dec 81 | r15        | Detroit LionsDetroit Lions | 45 - 7 | Minnesota VikingsMinnesota Vik |
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| 20 Dec 81 | r16        | Detroit LionsDetroit Lions | 17 - 20 | Tampa Bay BuccaneersTampa Bay Buc |