| 06 Sep 81 | r01        | Chicago BearsChicago Bears | 9 - 16 | Green Bay PackersGreen Bay Pac |
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| 13 Sep 81 | r02        | San Francisco 49ersSan Francisco | 28 - 17 | Chicago BearsChicago Bears |
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| 20 Sep 81 | r03        | Chicago BearsChicago Bears | 28 - 17 | Tampa Bay BuccaneersTampa Bay Buc |
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| 29 Sep 81 | r04        | Chicago BearsChicago Bears | 7 - 24 | Los Angeles RamsLos Angeles R |
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| 04 Oct 81 | r05        | Minnesota VikingsMinnesota Vik | 24 - 21 | Chicago BearsChicago Bears |
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| 11 Oct 81 | r06        | Chicago BearsChicago Bears | 7 - 24 | Washington CommandersWashington Co |
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| 20 Oct 81 | r07        | Detroit LionsDetroit Lions | 48 - 17 | Chicago BearsChicago Bears |
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| 25 Oct 81 | r08        | Chicago BearsChicago Bears | 20 - 17 | Los Angeles ChargersLos Angeles C |
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| 01 Nov 81 | r09        | Tampa Bay BuccaneersTampa Bay Buc | 20 - 10 | Chicago BearsChicago Bears |
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| 08 Nov 81 | r10        | Kansas City ChiefsKansas City C | 13 - 16 | Chicago BearsChicago Bears |
| 15 Nov 81 | r10        | Green Bay PackersGreen Bay Pac | 21 - 17 | Chicago BearsChicago Bears |
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| 22 Nov 81 | r12        | Chicago BearsChicago Bears | 7 - 23 | Detroit LionsDetroit Lions |
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| 26 Nov 81 | r13        | Dallas CowboysDallas Cowboy | 10 - 9 | Chicago BearsChicago Bears |
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| 06 Dec 81 | r14        | Chicago BearsChicago Bears | 10 - 9 | Minnesota VikingsMinnesota Vik |
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| 13 Dec 81 | r15        | Las Vegas RaidersLas Vegas Rai | 6 - 23 | Chicago BearsChicago Bears |
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| 20 Dec 81 | r16        | Chicago BearsChicago Bears | 35 - 24 | Denver BroncosDenver Bronco |