| 06 Sep 81 | r01        | Washington CommandersWashington Co | 10 - 26 | Dallas CowboysDallas Cowboy |
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| 13 Sep 81 | r02        | Washington CommandersWashington Co | 7 - 17 | New York GiantsNew York Gian |
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| 20 Sep 81 | r03        | Arizona CardinalsArizona Cardi | 40 - 30 | Washington CommandersWashington Co |
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| 27 Sep 81 | r04        | Philadelphia EaglesPhiladelphia | 36 - 13 | Washington CommandersWashington Co |
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| 04 Oct 81 | r05        | Washington CommandersWashington Co | 17 - 30 | San Francisco 49ersSan Francisco |
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| 11 Oct 81 | r06        | Chicago BearsChicago Bears | 7 - 24 | Washington CommandersWashington Co |
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| 18 Oct 81 | r07        | Miami DolphinsMiami Dolphin | 13 - 10 | Washington CommandersWashington Co |
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| 25 Oct 81 | r08        | Washington CommandersWashington Co | 24 - 22 | New England PatriotsNew England P |
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| 01 Nov 81 | r09        | Washington CommandersWashington Co | 42 - 21 | Arizona CardinalsArizona Cardi |
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| 08 Nov 81 | r10        | Washington CommandersWashington Co | 33 - 31 | Detroit LionsDetroit Lions |
| 15 Nov 81 | r10        | New York GiantsNew York Gian | 27 - 30 | Washington CommandersWashington Co |
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| 22 Nov 81 | r12        | Dallas CowboysDallas Cowboy | 24 - 10 | Washington CommandersWashington Co |
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| 29 Nov 81 | r13        | Buffalo BillsBuffalo Bills | 21 - 14 | Washington CommandersWashington Co |
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| 06 Dec 81 | r14        | Washington CommandersWashington Co | 15 - 13 | Philadelphia EaglesPhiladelphia |
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| 13 Dec 81 | r15        | Washington CommandersWashington Co | 38 - 14 | Indianapolis ColtsIndianapolis |
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| 20 Dec 81 | r16        | Los Angeles RamsLos Angeles R | 7 - 30 | Washington CommandersWashington Co |