| 06 Sep 81 | r01        | New York GiantsNew York Gian | 10 - 24 | Philadelphia EaglesPhiladelphia |
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| 13 Sep 81 | r02        | Philadelphia EaglesPhiladelphia | 13 - 3 | New England PatriotsNew England P |
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| 18 Sep 81 | r03        | Buffalo BillsBuffalo Bills | 14 - 20 | Philadelphia EaglesPhiladelphia |
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| 27 Sep 81 | r04        | Philadelphia EaglesPhiladelphia | 36 - 13 | Washington CommandersWashington Co |
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| 06 Oct 81 | r05        | Philadelphia EaglesPhiladelphia | 16 - 13 | Atlanta FalconsAtlanta Falco |
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| 11 Oct 81 | r06        | New Orleans SaintsNew Orleans S | 14 - 31 | Philadelphia EaglesPhiladelphia |
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| 18 Oct 81 | r07        | Minnesota VikingsMinnesota Vik | 35 - 23 | Philadelphia EaglesPhiladelphia |
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| 25 Oct 81 | r08        | Philadelphia EaglesPhiladelphia | 20 - 10 | Tampa Bay BuccaneersTampa Bay Buc |
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| 01 Nov 81 | r09        | Philadelphia EaglesPhiladelphia | 14 - 17 | Dallas CowboysDallas Cowboy |
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| 08 Nov 81 | r10        | Arizona CardinalsArizona Cardi | 10 - 52 | Philadelphia EaglesPhiladelphia |
| 15 Nov 81 | r10        | Philadelphia EaglesPhiladelphia | 38 - 13 | Indianapolis ColtsIndianapolis |
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| 22 Nov 81 | r12        | Philadelphia EaglesPhiladelphia | 10 - 20 | New York GiantsNew York Gian |
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| 01 Dec 81 | r13        | Miami DolphinsMiami Dolphin | 13 - 10 | Philadelphia EaglesPhiladelphia |
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| 06 Dec 81 | r14        | Washington CommandersWashington Co | 15 - 13 | Philadelphia EaglesPhiladelphia |
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| 13 Dec 81 | r15        | Dallas CowboysDallas Cowboy | 21 - 10 | Philadelphia EaglesPhiladelphia |
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| 20 Dec 81 | r16        | Philadelphia EaglesPhiladelphia | 38 - 0 | Arizona CardinalsArizona Cardi |
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| 27 Dec 81 | Playoff        | Philadelphia EaglesPhiladelphia | 21 - 27 | New York GiantsNew York Gian |