| 06 Sep 81 | r01        | Los Angeles RamsLos Angeles R | 20 - 27 | Tennessee TitansTennessee Tit |
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| 13 Sep 81 | r02        | Cleveland BrownsCleveland Bro | 3 - 9 | Tennessee TitansTennessee Tit |
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| 20 Sep 81 | r03        | Tennessee TitansTennessee Tit | 10 - 16 | Miami DolphinsMiami Dolphin |
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| 27 Sep 81 | r04        | New York JetsNew York Jets | 33 - 17 | Tennessee TitansTennessee Tit |
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| 04 Oct 81 | r05        | Tennessee TitansTennessee Tit | 17 - 10 | Cincinnati BengalsCincinnati Be |
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| 11 Oct 81 | r06        | Tennessee TitansTennessee Tit | 35 - 17 | Seattle SeahawksSeattle Seaha |
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| 18 Oct 81 | r07        | New England PatriotsNew England P | 38 - 10 | Tennessee TitansTennessee Tit |
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| 27 Oct 81 | r08        | Pittsburgh SteelersPittsburgh St | 26 - 13 | Tennessee TitansTennessee Tit |
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| 01 Nov 81 | r09        | Cincinnati BengalsCincinnati Be | 34 - 21 | Tennessee TitansTennessee Tit |
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| 08 Nov 81 | r10        | Tennessee TitansTennessee Tit | 17 - 16 | Las Vegas RaidersLas Vegas Rai |
| 15 Nov 81 | r10        | Kansas City ChiefsKansas City C | 23 - 10 | Tennessee TitansTennessee Tit |
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| 22 Nov 81 | r12        | Tennessee TitansTennessee Tit | 24 - 27 | New Orleans SaintsNew Orleans S |
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| 29 Nov 81 | r13        | Tennessee TitansTennessee Tit | 27 - 31 | Atlanta FalconsAtlanta Falco |
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| 04 Dec 81 | r14        | Tennessee TitansTennessee Tit | 17 - 13 | Cleveland BrownsCleveland Bro |
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| 13 Dec 81 | r15        | San Francisco 49ersSan Francisco | 28 - 6 | Tennessee TitansTennessee Tit |
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| 20 Dec 81 | r16        | Tennessee TitansTennessee Tit | 21 - 20 | Pittsburgh SteelersPittsburgh St |