| 06 Sep 81 | r01        | Pittsburgh SteelersPittsburgh St | 33 - 37 | Kansas City ChiefsKansas City C |
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| 11 Sep 81 | r02        | Miami DolphinsMiami Dolphin | 30 - 10 | Pittsburgh SteelersPittsburgh St |
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| 20 Sep 81 | r03        | Pittsburgh SteelersPittsburgh St | 38 - 10 | New York JetsNew York Jets |
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| 27 Sep 81 | r04        | Pittsburgh SteelersPittsburgh St | 27 - 21 | New England PatriotsNew England P |
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| 04 Oct 81 | r05        | New Orleans SaintsNew Orleans S | 6 - 20 | Pittsburgh SteelersPittsburgh St |
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| 11 Oct 81 | r06        | Pittsburgh SteelersPittsburgh St | 13 - 7 | Cleveland BrownsCleveland Bro |
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| 18 Oct 81 | r07        | Cincinnati BengalsCincinnati Be | 34 - 7 | Pittsburgh SteelersPittsburgh St |
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| 27 Oct 81 | r08        | Pittsburgh SteelersPittsburgh St | 26 - 13 | Tennessee TitansTennessee Tit |
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| 01 Nov 81 | r09        | Pittsburgh SteelersPittsburgh St | 14 - 17 | San Francisco 49ersSan Francisco |
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| 08 Nov 81 | r10        | Seattle SeahawksSeattle Seaha | 24 - 21 | Pittsburgh SteelersPittsburgh St |
| 15 Nov 81 | r10        | Atlanta FalconsAtlanta Falco | 20 - 34 | Pittsburgh SteelersPittsburgh St |
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| 22 Nov 81 | r12        | Cleveland BrownsCleveland Bro | 10 - 32 | Pittsburgh SteelersPittsburgh St |
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| 29 Nov 81 | r13        | Pittsburgh SteelersPittsburgh St | 24 - 0 | Los Angeles RamsLos Angeles R |
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| 08 Dec 81 | r14        | Las Vegas RaidersLas Vegas Rai | 30 - 27 | Pittsburgh SteelersPittsburgh St |
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| 13 Dec 81 | r15        | Pittsburgh SteelersPittsburgh St | 10 - 17 | Cincinnati BengalsCincinnati Be |
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| 20 Dec 81 | r16        | Tennessee TitansTennessee Tit | 21 - 20 | Pittsburgh SteelersPittsburgh St |