| 06 Sep 81 | r01        | New England PatriotsNew England P | 28 - 29 | Indianapolis ColtsIndianapolis |
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| 13 Sep 81 | r02        | Philadelphia EaglesPhiladelphia | 13 - 3 | New England PatriotsNew England P |
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| 22 Sep 81 | r03        | New England PatriotsNew England P | 21 - 35 | Dallas CowboysDallas Cowboy |
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| 27 Sep 81 | r04        | Pittsburgh SteelersPittsburgh St | 27 - 21 | New England PatriotsNew England P |
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| 04 Oct 81 | r05        | New England PatriotsNew England P | 33 - 17 | Kansas City ChiefsKansas City C |
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| 11 Oct 81 | r06        | New York JetsNew York Jets | 28 - 24 | New England PatriotsNew England P |
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| 18 Oct 81 | r07        | New England PatriotsNew England P | 38 - 10 | Tennessee TitansTennessee Tit |
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| 25 Oct 81 | r08        | Washington CommandersWashington Co | 24 - 22 | New England PatriotsNew England P |
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| 01 Nov 81 | r09        | Las Vegas RaidersLas Vegas Rai | 27 - 17 | New England PatriotsNew England P |
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| 08 Nov 81 | r10        | New England PatriotsNew England P | 27 - 30 | Miami DolphinsMiami Dolphin |
| 15 Nov 81 | r10        | New England PatriotsNew England P | 6 - 17 | New York JetsNew York Jets |
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| 22 Nov 81 | r12        | Buffalo BillsBuffalo Bills | 20 - 17 | New England PatriotsNew England P |
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| 29 Nov 81 | r13        | New England PatriotsNew England P | 20 - 27 | Arizona CardinalsArizona Cardi |
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| 06 Dec 81 | r14        | Miami DolphinsMiami Dolphin | 24 - 14 | New England PatriotsNew England P |
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| 13 Dec 81 | r15        | New England PatriotsNew England P | 10 - 19 | Buffalo BillsBuffalo Bills |
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| 20 Dec 81 | r16        | Indianapolis ColtsIndianapolis | 23 - 21 | New England PatriotsNew England P |