| 06 Sep 81 | r01        | Buffalo BillsBuffalo Bills | 31 - 0 | New York JetsNew York Jets |
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| 13 Sep 81 | r02        | Indianapolis ColtsIndianapolis | 3 - 35 | Buffalo BillsBuffalo Bills |
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| 18 Sep 81 | r03        | Buffalo BillsBuffalo Bills | 14 - 20 | Philadelphia EaglesPhiladelphia |
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| 27 Sep 81 | r04        | Cincinnati BengalsCincinnati Be | 27 - 24 | Buffalo BillsBuffalo Bills |
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| 04 Oct 81 | r05        | Buffalo BillsBuffalo Bills | 23 - 17 | Indianapolis ColtsIndianapolis |
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| 13 Oct 81 | r06        | Buffalo BillsBuffalo Bills | 31 - 21 | Miami DolphinsMiami Dolphin |
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| 18 Oct 81 | r07        | New York JetsNew York Jets | 33 - 14 | Buffalo BillsBuffalo Bills |
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| 25 Oct 81 | r08        | Buffalo BillsBuffalo Bills | 9 - 7 | Denver BroncosDenver Bronco |
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| 01 Nov 81 | r09        | Buffalo BillsBuffalo Bills | 22 - 13 | Cleveland BrownsCleveland Bro |
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| 10 Nov 81 | r10        | Dallas CowboysDallas Cowboy | 27 - 14 | Buffalo BillsBuffalo Bills |
| 15 Nov 81 | r10        | Arizona CardinalsArizona Cardi | 24 - 0 | Buffalo BillsBuffalo Bills |
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| 22 Nov 81 | r12        | Buffalo BillsBuffalo Bills | 20 - 17 | New England PatriotsNew England P |
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| 29 Nov 81 | r13        | Buffalo BillsBuffalo Bills | 21 - 14 | Washington CommandersWashington Co |
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| 06 Dec 81 | r14        | Los Angeles ChargersLos Angeles C | 27 - 28 | Buffalo BillsBuffalo Bills |
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| 13 Dec 81 | r15        | New England PatriotsNew England P | 10 - 19 | Buffalo BillsBuffalo Bills |
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| 19 Dec 81 | r16        | Miami DolphinsMiami Dolphin | 16 - 6 | Buffalo BillsBuffalo Bills |
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| 27 Dec 81 | Playoff        | New York JetsNew York Jets | 27 - 31 | Buffalo BillsBuffalo Bills |
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| 03 Jan 82 | QF        | Cincinnati BengalsCincinnati Be | 28 - 21 | Buffalo BillsBuffalo Bills |