| 01 Nov 81 | r09        | Buffalo BillsBuffalo Bills | 22 - 13 | Cleveland BrownsCleveland Bro |
| 01 Nov 81 | r09        | Cincinnati BengalsCincinnati Be | 34 - 21 | Tennessee TitansTennessee Tit |
| 01 Nov 81 | r09        | Miami DolphinsMiami Dolphin | 27 - 10 | Indianapolis ColtsIndianapolis |
| 01 Nov 81 | r09        | New Orleans SaintsNew Orleans S | 10 - 41 | Atlanta FalconsAtlanta Falco |
| 01 Nov 81 | r09        | New York GiantsNew York Gian | 7 - 26 | New York JetsNew York Jets |
| 01 Nov 81 | r09        | Pittsburgh SteelersPittsburgh St | 14 - 17 | San Francisco 49ersSan Francisco |
| 01 Nov 81 | r09        | Tampa Bay BuccaneersTampa Bay Buc | 20 - 10 | Chicago BearsChicago Bears |
| 01 Nov 81 | r09        | Green Bay PackersGreen Bay Pac | 34 - 24 | Seattle SeahawksSeattle Seaha |
| 01 Nov 81 | r09        | Las Vegas RaidersLas Vegas Rai | 27 - 17 | New England PatriotsNew England P |
| 01 Nov 81 | r09        | Los Angeles ChargersLos Angeles C | 22 - 20 | Kansas City ChiefsKansas City C |
| 01 Nov 81 | r09        | Los Angeles RamsLos Angeles R | 20 - 13 | Detroit LionsDetroit Lions |
| 01 Nov 81 | r09        | Philadelphia EaglesPhiladelphia | 14 - 17 | Dallas CowboysDallas Cowboy |
| 01 Nov 81 | r09        | Washington CommandersWashington Co | 42 - 21 | Arizona CardinalsArizona Cardi |
| 03 Nov 81 | r09        | Denver BroncosDenver Bronco | 19 - 17 | Minnesota VikingsMinnesota Vik |