| 04 Oct 81 | r05        | Arizona CardinalsArizona Cardi | 20 - 17 | Dallas CowboysDallas Cowboy |
| 04 Oct 81 | r05        | Minnesota VikingsMinnesota Vik | 24 - 21 | Chicago BearsChicago Bears |
| 04 Oct 81 | r05        | Buffalo BillsBuffalo Bills | 23 - 17 | Indianapolis ColtsIndianapolis |
| 04 Oct 81 | r05        | New England PatriotsNew England P | 33 - 17 | Kansas City ChiefsKansas City C |
| 04 Oct 81 | r05        | New York GiantsNew York Gian | 14 - 27 | Green Bay PackersGreen Bay Pac |
| 04 Oct 81 | r05        | Washington CommandersWashington Co | 17 - 30 | San Francisco 49ersSan Francisco |
| 04 Oct 81 | r05        | New Orleans SaintsNew Orleans S | 6 - 20 | Pittsburgh SteelersPittsburgh St |
| 04 Oct 81 | r05        | Tennessee TitansTennessee Tit | 17 - 10 | Cincinnati BengalsCincinnati Be |
| 04 Oct 81 | r05        | Las Vegas RaidersLas Vegas Rai | 0 - 17 | Denver BroncosDenver Bronco |
| 04 Oct 81 | r05        | Los Angeles ChargersLos Angeles C | 24 - 10 | Seattle SeahawksSeattle Seaha |
| 04 Oct 81 | r05        | Los Angeles RamsLos Angeles R | 27 - 16 | Cleveland BrownsCleveland Bro |
| 04 Oct 81 | r05        | Miami DolphinsMiami Dolphin | 28 - 28 | New York JetsNew York Jets |
| 04 Oct 81 | r05        | Tampa Bay BuccaneersTampa Bay Buc | 28 - 10 | Detroit LionsDetroit Lions |
| 06 Oct 81 | r05        | Philadelphia EaglesPhiladelphia | 16 - 13 | Atlanta FalconsAtlanta Falco |