| 02 Sep 79 | r01        | Tampa Bay BuccaneersTampa Bay Buc | 31 - 16 | Detroit LionsDetroit Lions |
| |
| 09 Sep 79 | r02        | Detroit LionsDetroit Lions | 24 - 27 | Washington CommandersWashington Co |
| |
| 16 Sep 79 | r03        | New York JetsNew York Jets | 31 - 10 | Detroit LionsDetroit Lions |
| |
| 23 Sep 79 | r04        | Detroit LionsDetroit Lions | 24 - 23 | Atlanta FalconsAtlanta Falco |
| |
| 30 Sep 79 | r05        | Detroit LionsDetroit Lions | 10 - 13 | Minnesota VikingsMinnesota Vik |
| |
| 07 Oct 79 | r06        | New England PatriotsNew England P | 24 - 17 | Detroit LionsDetroit Lions |
| |
| 14 Oct 79 | r07        | Green Bay PackersGreen Bay Pac | 24 - 16 | Detroit LionsDetroit Lions |
| |
| 21 Oct 79 | r08        | New Orleans SaintsNew Orleans S | 17 - 7 | Detroit LionsDetroit Lions |
| |
| 28 Oct 79 | r09        | Detroit LionsDetroit Lions | 17 - 20 | Buffalo BillsBuffalo Bills |
| |
| 04 Nov 79 | r10        | Chicago BearsChicago Bears | 35 - 7 | Detroit LionsDetroit Lions |
| 11 Nov 79 | r10        | Detroit LionsDetroit Lions | 14 - 16 | Tampa Bay BuccaneersTampa Bay Buc |
| |
| 18 Nov 79 | r12        | Minnesota VikingsMinnesota Vik | 14 - 7 | Detroit LionsDetroit Lions |
| |
| 22 Nov 79 | r13        | Detroit LionsDetroit Lions | 20 - 0 | Chicago BearsChicago Bears |
| |
| 02 Dec 79 | r14        | Philadelphia EaglesPhiladelphia | 44 - 7 | Detroit LionsDetroit Lions |
| |
| 09 Dec 79 | r15        | Detroit LionsDetroit Lions | 10 - 28 | Miami DolphinsMiami Dolphin |
| |
| 15 Dec 79 | r16        | Detroit LionsDetroit Lions | 13 - 18 | Green Bay PackersGreen Bay Pac |