| 02 Sep 79 | r01        | Buffalo BillsBuffalo Bills | 7 - 9 | Miami DolphinsMiami Dolphin |
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| 09 Sep 79 | r02        | Buffalo BillsBuffalo Bills | 51 - 24 | Cincinnati BengalsCincinnati Be |
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| 16 Sep 79 | r03        | Los Angeles ChargersLos Angeles C | 27 - 19 | Buffalo BillsBuffalo Bills |
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| 23 Sep 79 | r04        | Buffalo BillsBuffalo Bills | 46 - 31 | New York JetsNew York Jets |
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| 30 Sep 79 | r05        | Indianapolis ColtsIndianapolis | 13 - 31 | Buffalo BillsBuffalo Bills |
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| 07 Oct 79 | r06        | Buffalo BillsBuffalo Bills | 0 - 7 | Chicago BearsChicago Bears |
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| 14 Oct 79 | r07        | Miami DolphinsMiami Dolphin | 17 - 7 | Buffalo BillsBuffalo Bills |
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| 21 Oct 79 | r08        | Buffalo BillsBuffalo Bills | 13 - 14 | Indianapolis ColtsIndianapolis |
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| 28 Oct 79 | r09        | Detroit LionsDetroit Lions | 17 - 20 | Buffalo BillsBuffalo Bills |
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| 04 Nov 79 | r10        | Buffalo BillsBuffalo Bills | 6 - 26 | New England PatriotsNew England P |
| 11 Nov 79 | r10        | New York JetsNew York Jets | 12 - 14 | Buffalo BillsBuffalo Bills |
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| 18 Nov 79 | r12        | Buffalo BillsBuffalo Bills | 19 - 12 | Green Bay PackersGreen Bay Pac |
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| 25 Nov 79 | r13        | New England PatriotsNew England P | 13 - 16 | Buffalo BillsBuffalo Bills |
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| 02 Dec 79 | r14        | Buffalo BillsBuffalo Bills | 16 - 19 | Denver BroncosDenver Bronco |
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| 09 Dec 79 | r15        | Minnesota VikingsMinnesota Vik | 10 - 3 | Buffalo BillsBuffalo Bills |
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| 16 Dec 79 | r16        | Pittsburgh SteelersPittsburgh St | 28 - 0 | Buffalo BillsBuffalo Bills |