| 03 Sep 78 | r01        | Chicago BearsChicago Bears | 17 - 10 | Arizona CardinalsArizona Cardi |
| |
| 10 Sep 78 | r02        | Arizona CardinalsArizona Cardi | 6 - 16 | New England PatriotsNew England P |
| |
| 17 Sep 78 | r03        | Arizona CardinalsArizona Cardi | 10 - 28 | Washington CommandersWashington Co |
| |
| 24 Sep 78 | r04        | Dallas CowboysDallas Cowboy | 21 - 12 | Arizona CardinalsArizona Cardi |
| |
| 01 Oct 78 | r05        | Miami DolphinsMiami Dolphin | 24 - 10 | Arizona CardinalsArizona Cardi |
| |
| 08 Oct 78 | r06        | Arizona CardinalsArizona Cardi | 17 - 30 | Indianapolis ColtsIndianapolis |
| |
| 15 Oct 78 | r07        | Arizona CardinalsArizona Cardi | 21 - 24 | Dallas CowboysDallas Cowboy |
| |
| 22 Oct 78 | r08        | New York JetsNew York Jets | 23 - 10 | Arizona CardinalsArizona Cardi |
| |
| 29 Oct 78 | r09        | Philadelphia EaglesPhiladelphia | 10 - 16 | Arizona CardinalsArizona Cardi |
| |
| 05 Nov 78 | r10        | Arizona CardinalsArizona Cardi | 20 - 10 | New York GiantsNew York Gian |
| 12 Nov 78 | r10        | San Francisco 49ersSan Francisco | 10 - 16 | Arizona CardinalsArizona Cardi |
| |
| 19 Nov 78 | r12        | Washington CommandersWashington Co | 17 - 27 | Arizona CardinalsArizona Cardi |
| |
| 26 Nov 78 | r13        | Arizona CardinalsArizona Cardi | 10 - 14 | Philadelphia EaglesPhiladelphia |
| |
| 03 Dec 78 | r14        | Arizona CardinalsArizona Cardi | 21 - 14 | Detroit LionsDetroit Lions |
| |
| 10 Dec 78 | r15        | New York GiantsNew York Gian | 17 - 0 | Arizona CardinalsArizona Cardi |
| |
| 17 Dec 78 | r16        | Arizona CardinalsArizona Cardi | 42 - 21 | Atlanta FalconsAtlanta Falco |