| 03 Sep 78 | r01        | Tampa Bay BuccaneersTampa Bay Buc | 13 - 19 | New York GiantsNew York Gian |
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| 10 Sep 78 | r02        | Tampa Bay BuccaneersTampa Bay Buc | 7 - 15 | Detroit LionsDetroit Lions |
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| 17 Sep 78 | r03        | Minnesota VikingsMinnesota Vik | 10 - 16 | Tampa Bay BuccaneersTampa Bay Buc |
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| 24 Sep 78 | r04        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 9 | Atlanta FalconsAtlanta Falco |
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| 01 Oct 78 | r05        | Tampa Bay BuccaneersTampa Bay Buc | 7 - 24 | Minnesota VikingsMinnesota Vik |
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| 08 Oct 78 | r06        | Kansas City ChiefsKansas City C | 13 - 30 | Tampa Bay BuccaneersTampa Bay Buc |
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| 15 Oct 78 | r07        | New York GiantsNew York Gian | 17 - 14 | Tampa Bay BuccaneersTampa Bay Buc |
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| 22 Oct 78 | r08        | Tampa Bay BuccaneersTampa Bay Buc | 33 - 19 | Chicago BearsChicago Bears |
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| 29 Oct 78 | r09        | Green Bay PackersGreen Bay Pac | 9 - 7 | Tampa Bay BuccaneersTampa Bay Buc |
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| 05 Nov 78 | r10        | Los Angeles RamsLos Angeles R | 26 - 23 | Tampa Bay BuccaneersTampa Bay Buc |
| 12 Nov 78 | r10        | Detroit LionsDetroit Lions | 34 - 23 | Tampa Bay BuccaneersTampa Bay Buc |
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| 19 Nov 78 | r12        | Tampa Bay BuccaneersTampa Bay Buc | 31 - 10 | Buffalo BillsBuffalo Bills |
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| 26 Nov 78 | r13        | Chicago BearsChicago Bears | 14 - 3 | Tampa Bay BuccaneersTampa Bay Buc |
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| 03 Dec 78 | r14        | Tampa Bay BuccaneersTampa Bay Buc | 7 - 17 | Green Bay PackersGreen Bay Pac |
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| 10 Dec 78 | r15        | San Francisco 49ersSan Francisco | 6 - 3 | Tampa Bay BuccaneersTampa Bay Buc |
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| 17 Dec 78 | r16        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 17 | New Orleans SaintsNew Orleans S |