| 03 Sep 78 | r01        | Detroit LionsDetroit Lions | 7 - 13 | Green Bay PackersGreen Bay Pac |
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| 10 Sep 78 | r02        | Tampa Bay BuccaneersTampa Bay Buc | 7 - 15 | Detroit LionsDetroit Lions |
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| 17 Sep 78 | r03        | Detroit LionsDetroit Lions | 0 - 19 | Chicago BearsChicago Bears |
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| 24 Sep 78 | r04        | Seattle SeahawksSeattle Seaha | 28 - 16 | Detroit LionsDetroit Lions |
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| 01 Oct 78 | r05        | Green Bay PackersGreen Bay Pac | 35 - 14 | Detroit LionsDetroit Lions |
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| 08 Oct 78 | r06        | Detroit LionsDetroit Lions | 19 - 21 | Washington CommandersWashington Co |
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| 15 Oct 78 | r07        | Atlanta FalconsAtlanta Falco | 14 - 0 | Detroit LionsDetroit Lions |
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| 22 Oct 78 | r08        | Detroit LionsDetroit Lions | 31 - 14 | Los Angeles ChargersLos Angeles C |
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| 29 Oct 78 | r09        | Chicago BearsChicago Bears | 17 - 21 | Detroit LionsDetroit Lions |
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| 05 Nov 78 | r10        | Minnesota VikingsMinnesota Vik | 17 - 7 | Detroit LionsDetroit Lions |
| 12 Nov 78 | r10        | Detroit LionsDetroit Lions | 34 - 23 | Tampa Bay BuccaneersTampa Bay Buc |
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| 19 Nov 78 | r12        | Las Vegas RaidersLas Vegas Rai | 29 - 17 | Detroit LionsDetroit Lions |
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| 23 Nov 78 | r13        | Detroit LionsDetroit Lions | 17 - 14 | Denver BroncosDenver Bronco |
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| 03 Dec 78 | r14        | Arizona CardinalsArizona Cardi | 21 - 14 | Detroit LionsDetroit Lions |
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| 09 Dec 78 | r15        | Detroit LionsDetroit Lions | 45 - 14 | Minnesota VikingsMinnesota Vik |
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| 17 Dec 78 | r16        | Detroit LionsDetroit Lions | 33 - 14 | San Francisco 49ersSan Francisco |