| 03 Sep 78 | r01        | New England PatriotsNew England P | 14 - 16 | Washington CommandersWashington Co |
| |
| 10 Sep 78 | r02        | Arizona CardinalsArizona Cardi | 6 - 16 | New England PatriotsNew England P |
| |
| 19 Sep 78 | r03        | New England PatriotsNew England P | 27 - 34 | Indianapolis ColtsIndianapolis |
| |
| 25 Sep 78 | r04        | Las Vegas RaidersLas Vegas Rai | 14 - 21 | New England PatriotsNew England P |
| |
| 01 Oct 78 | r05        | New England PatriotsNew England P | 28 - 23 | Los Angeles ChargersLos Angeles C |
| |
| 08 Oct 78 | r06        | New England PatriotsNew England P | 24 - 14 | Philadelphia EaglesPhiladelphia |
| |
| 15 Oct 78 | r07        | Cincinnati BengalsCincinnati Be | 3 - 10 | New England PatriotsNew England P |
| |
| 22 Oct 78 | r08        | New England PatriotsNew England P | 33 - 24 | Miami DolphinsMiami Dolphin |
| |
| 29 Oct 78 | r09        | New England PatriotsNew England P | 55 - 21 | New York JetsNew York Jets |
| |
| 05 Nov 78 | r10        | Buffalo BillsBuffalo Bills | 10 - 14 | New England PatriotsNew England P |
| 12 Nov 78 | r10        | New England PatriotsNew England P | 23 - 26 | Tennessee TitansTennessee Tit |
| |
| 19 Nov 78 | r12        | New York JetsNew York Jets | 17 - 19 | New England PatriotsNew England P |
| |
| 26 Nov 78 | r13        | Indianapolis ColtsIndianapolis | 14 - 35 | New England PatriotsNew England P |
| |
| 03 Dec 78 | r14        | Dallas CowboysDallas Cowboy | 17 - 10 | New England PatriotsNew England P |
| |
| 10 Dec 78 | r15        | New England PatriotsNew England P | 26 - 24 | Buffalo BillsBuffalo Bills |
| |
| 19 Dec 78 | r16        | Miami DolphinsMiami Dolphin | 23 - 3 | New England PatriotsNew England P |
| |
| 31 Dec 78 | QF        | New England PatriotsNew England P | 14 - 31 | Tennessee TitansTennessee Tit |