| 15 Sep 68 | r01        | Indianapolis ColtsIndianapolis | 27 - 10 | San Francisco 49ersSan Francisco |
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| 22 Sep 68 | r02        | San Francisco 49ersSan Francisco | 35 - 17 | Arizona CardinalsArizona Cardi |
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| 29 Sep 68 | r03        | San Francisco 49ersSan Francisco | 28 - 13 | Atlanta FalconsAtlanta Falco |
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| 06 Oct 68 | r04        | Los Angeles RamsLos Angeles R | 24 - 10 | San Francisco 49ersSan Francisco |
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| 13 Oct 68 | r05        | San Francisco 49ersSan Francisco | 14 - 42 | Indianapolis ColtsIndianapolis |
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| 20 Oct 68 | r06        | New York GiantsNew York Gian | 10 - 26 | San Francisco 49ersSan Francisco |
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| 27 Oct 68 | r07        | Detroit LionsDetroit Lions | 7 - 14 | San Francisco 49ersSan Francisco |
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| 03 Nov 68 | r08        | San Francisco 49ersSan Francisco | 21 - 33 | Cleveland BrownsCleveland Bro |
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| 10 Nov 68 | r09        | Chicago BearsChicago Bears | 27 - 19 | San Francisco 49ersSan Francisco |
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| 17 Nov 68 | r10        | San Francisco 49ersSan Francisco | 20 - 20 | Los Angeles RamsLos Angeles R |
| 24 Nov 68 | r10        | Pittsburgh SteelersPittsburgh St | 28 - 45 | San Francisco 49ersSan Francisco |
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| 01 Dec 68 | r12        | San Francisco 49ersSan Francisco | 27 - 20 | Green Bay PackersGreen Bay Pac |
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| 08 Dec 68 | r13        | San Francisco 49ersSan Francisco | 20 - 30 | Minnesota VikingsMinnesota Vik |
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| 15 Dec 68 | r14        | Atlanta FalconsAtlanta Falco | 12 - 14 | San Francisco 49ersSan Francisco |