| 26 Sep 21 | r00        | St. Louis BluesSt. Louis Blu | 6 - 2 | Minnesota WildMinnesota Wil |
| 28 Sep 21 | r00        | St. Louis BluesSt. Louis Blu | 2 - 1 | Dallas StarsDallas Stars |
| 30 Sep 21 | r00        | Columbus Blue JacketsColumbus Blue | 5 - 2 | St. Louis BluesSt. Louis Blu |
| 02 Oct 21 | r00        | Chicago BlackhawksChicago Black | 3 - 6 | St. Louis BluesSt. Louis Blu |
| 03 Oct 21 | r00        | St. Louis BluesSt. Louis Blu | 1 - 5 | Chicago BlackhawksChicago Black |
| 06 Oct 21 | r00        | Dallas StarsDallas Stars | 3 - 1 | St. Louis BluesSt. Louis Blu |
| 07 Oct 21 | r00        | Minnesota WildMinnesota Wil | 4 - 3 | St. Louis BluesSt. Louis Blu |
| 09 Oct 21 | r00        | St. Louis BluesSt. Louis Blu | 7 - 3 | Columbus Blue JacketsColumbus Blue |
| 17 Oct 21 | r00        | Colorado AvalancheColorado Aval | 3 - 5 | St. Louis BluesSt. Louis Blu |
| 19 Oct 21 | r00        | Arizona CoyotesArizona Coyot | 4 - 7 | St. Louis BluesSt. Louis Blu |
| 21 Oct 21 | r00        | Vegas Golden KnightsVegas Golden | 1 - 3 | St. Louis BluesSt. Louis Blu |
| 24 Oct 21 | r00        | St. Louis BluesSt. Louis Blu | 7 - 3 | Los Angeles KingsLos Angeles K |
| 26 Oct 21 | r00        | St. Louis BluesSt. Louis Blu | 3 - 0 | Los Angeles KingsLos Angeles K |
| 29 Oct 21 | r00        | St. Louis BluesSt. Louis Blu | 3 - 4 | Colorado AvalancheColorado Aval |
| 31 Oct 21 | r00        | St. Louis BluesSt. Louis Blu | 1 - 0 | Chicago BlackhawksChicago Black |
| 04 Nov 21 | r00        | Los Angeles KingsLos Angeles K | 3 - 2 | St. Louis BluesSt. Louis Blu |
| 05 Nov 21 | r00        | San Jose SharksSan Jose Shar | 3 - 5 | St. Louis BluesSt. Louis Blu |
| 08 Nov 21 | r00        | Anaheim DucksAnaheim Ducks | 4 - 1 | St. Louis BluesSt. Louis Blu |
| 10 Nov 21 | r00        | Winnipeg JetsWinnipeg Jets | 2 - 3 | St. Louis BluesSt. Louis Blu |
| 12 Nov 21 | r00        | St. Louis BluesSt. Louis Blu | 3 - 4 | Nashville PredatorsNashville Pre |
| 14 Nov 21 | r00        | Carolina HurricanesCarolina Hurr | 3 - 2 | St. Louis BluesSt. Louis Blu |
| 15 Nov 21 | r00        | St. Louis BluesSt. Louis Blu | 4 - 5 | Edmonton OilersEdmonton Oile |
| 17 Nov 21 | r00        | St. Louis BluesSt. Louis Blu | 2 - 3 | Arizona CoyotesArizona Coyot |
| 19 Nov 21 | r00        | St. Louis BluesSt. Louis Blu | 4 - 1 | San Jose SharksSan Jose Shar |
| 21 Nov 21 | r00        | Dallas StarsDallas Stars | 4 - 1 | St. Louis BluesSt. Louis Blu |
| 23 Nov 21 | r00        | St. Louis BluesSt. Louis Blu | 5 - 2 | Vegas Golden KnightsVegas Golden |
| 25 Nov 21 | r00        | Detroit Red WingsDetroit Red W | 4 - 2 | St. Louis BluesSt. Louis Blu |
| 26 Nov 21 | r00        | Chicago BlackhawksChicago Black | 3 - 2 | St. Louis BluesSt. Louis Blu |
| 28 Nov 21 | r00        | St. Louis BluesSt. Louis Blu | 6 - 3 | Columbus Blue JacketsColumbus Blue |
| 01 Dec 21 | r00        | St. Louis BluesSt. Louis Blu | 4 - 3 | Tampa Bay LightningTampa Bay Lig |
| 03 Dec 21 | r00        | Tampa Bay LightningTampa Bay Lig | 4 - 2 | St. Louis BluesSt. Louis Blu |
| 04 Dec 21 | r00        | Florida PanthersFlorida Panth | 4 - 3 | St. Louis BluesSt. Louis Blu |
| 08 Dec 21 | r00        | St. Louis BluesSt. Louis Blu | 4 - 3 | Florida PanthersFlorida Panth |
| 10 Dec 21 | r00        | St. Louis BluesSt. Louis Blu | 6 - 2 | Detroit Red WingsDetroit Red W |
| 12 Dec 21 | r00        | St. Louis BluesSt. Louis Blu | 4 - 1 | Montreal CanadiensMontreal Cana |
| 13 Dec 21 | r00        | St. Louis BluesSt. Louis Blu | 2 - 3 | Anaheim DucksAnaheim Ducks |
| 15 Dec 21 | r00        | Dallas StarsDallas Stars | 1 - 4 | St. Louis BluesSt. Louis Blu |
| 18 Dec 21 | r00        | St. Louis BluesSt. Louis Blu | 4 - 1 | Dallas StarsDallas Stars |
| 19 Dec 21 | r00        | Winnipeg JetsWinnipeg Jets | 4 - 2 | St. Louis BluesSt. Louis Blu |
| 30 Dec 21 | r00        | St. Louis BluesSt. Louis Blu | 4 - 2 | Edmonton OilersEdmonton Oile |
| 02 Jan 22 | r00        | Minnesota WildMinnesota Wil | 4 - 6 | St. Louis BluesSt. Louis Blu |
| 06 Jan 22 | r00        | Pittsburgh PenguinsPittsburgh Pe | 5 - 3 | St. Louis BluesSt. Louis Blu |
| 08 Jan 22 | r00        | St. Louis BluesSt. Louis Blu | 5 - 1 | Washington CapitalsWashington Ca |
| 09 Jan 22 | r00        | St. Louis BluesSt. Louis Blu | 2 - 1 | Dallas StarsDallas Stars |
| 14 Jan 22 | r00        | St. Louis BluesSt. Louis Blu | 2 - 1 | Seattle KrakenSeattle Krake |
| 16 Jan 22 | r00        | St. Louis BluesSt. Louis Blu | 5 - 6 | Toronto Maple LeafsToronto Maple |
| 18 Jan 22 | r00        | St. Louis BluesSt. Louis Blu | 5 - 3 | Nashville PredatorsNashville Pre |
| 22 Jan 22 | r00        | Seattle KrakenSeattle Krake | 0 - 5 | St. Louis BluesSt. Louis Blu |
| 24 Jan 22 | r00        | Vancouver CanucksVancouver Can | 1 - 3 | St. Louis BluesSt. Louis Blu |
| 25 Jan 22 | r00        | Calgary FlamesCalgary Flame | 7 - 1 | St. Louis BluesSt. Louis Blu |
| 28 Jan 22 | r00        | St. Louis BluesSt. Louis Blu | 5 - 1 | Calgary FlamesCalgary Flame |
| 29 Jan 22 | r00        | St. Louis BluesSt. Louis Blu | 1 - 4 | Winnipeg JetsWinnipeg Jets |
| 11 Feb 22 | r00        | St. Louis BluesSt. Louis Blu | 4 - 7 | New Jersey DevilsNew Jersey De |
| 13 Feb 22 | r00        | St. Louis BluesSt. Louis Blu | 5 - 1 | Chicago BlackhawksChicago Black |
| 16 Feb 22 | r00        | Ottawa SenatorsOttawa Senato | 2 - 5 | St. Louis BluesSt. Louis Blu |
| 18 Feb 22 | r00        | Montreal CanadiensMontreal Cana | 3 - 2 | St. Louis BluesSt. Louis Blu |
| 20 Feb 22 | r00        | Toronto Maple LeafsToronto Maple | 3 - 6 | St. Louis BluesSt. Louis Blu |
| 23 Feb 22 | r00        | Philadelphia FlyersPhiladelphia | 1 - 4 | St. Louis BluesSt. Louis Blu |
| 26 Feb 22 | r00        | St. Louis BluesSt. Louis Blu | 5 - 3 | Buffalo SabresBuffalo Sabre |
| 27 Feb 22 | r00        | Chicago BlackhawksChicago Black | 0 - 4 | St. Louis BluesSt. Louis Blu |
| 03 Mar 22 | r00        | New York RangersNew York Rang | 5 - 3 | St. Louis BluesSt. Louis Blu |
| 05 Mar 22 | r00        | New York IslandersNew York Isla | 2 - 1 | St. Louis BluesSt. Louis Blu |
| 06 Mar 22 | r00        | New Jersey DevilsNew Jersey De | 3 - 2 | St. Louis BluesSt. Louis Blu |
| 09 Mar 22 | r00        | St. Louis BluesSt. Louis Blu | 1 - 4 | Ottawa SenatorsOttawa Senato |
| 11 Mar 22 | r00        | St. Louis BluesSt. Louis Blu | 6 - 2 | New York RangersNew York Rang |
| 12 Mar 22 | r00        | Nashville PredatorsNashville Pre | 4 - 7 | St. Louis BluesSt. Louis Blu |
| 13 Mar 22 | r00        | St. Louis BluesSt. Louis Blu | 3 - 4 | Winnipeg JetsWinnipeg Jets |
| 18 Mar 22 | r00        | St. Louis BluesSt. Louis Blu | 2 - 3 | Pittsburgh PenguinsPittsburgh Pe |
| 19 Mar 22 | r00        | Columbus Blue JacketsColumbus Blue | 5 - 4 | St. Louis BluesSt. Louis Blu |
| 22 Mar 22 | r00        | Washington CapitalsWashington Ca | 2 - 5 | St. Louis BluesSt. Louis Blu |
| 25 Mar 22 | r00        | St. Louis BluesSt. Louis Blu | 2 - 5 | Philadelphia FlyersPhiladelphia |
| 27 Mar 22 | r00        | St. Louis BluesSt. Louis Blu | 2 - 7 | Carolina HurricanesCarolina Hurr |
| 29 Mar 22 | r00        | St. Louis BluesSt. Louis Blu | 4 - 1 | Vancouver CanucksVancouver Can |
| 31 Mar 22 | r00        | Vancouver CanucksVancouver Can | 3 - 4 | St. Louis BluesSt. Louis Blu |
| 02 Apr 22 | r00        | Edmonton OilersEdmonton Oile | 6 - 5 | St. Louis BluesSt. Louis Blu |
| 03 Apr 22 | r00        | Calgary FlamesCalgary Flame | 4 - 6 | St. Louis BluesSt. Louis Blu |
| 05 Apr 22 | r00        | St. Louis BluesSt. Louis Blu | 5 - 1 | Arizona CoyotesArizona Coyot |
| 07 Apr 22 | r00        | St. Louis BluesSt. Louis Blu | 4 - 1 | Seattle KrakenSeattle Krake |
| 09 Apr 22 | r00        | St. Louis BluesSt. Louis Blu | 4 - 3 | Minnesota WildMinnesota Wil |
| 10 Apr 22 | r00        | St. Louis BluesSt. Louis Blu | 6 - 1 | New York IslandersNew York Isla |
| 13 Apr 22 | r00        | Boston BruinsBoston Bruins | 2 - 4 | St. Louis BluesSt. Louis Blu |
| 15 Apr 22 | r00        | Buffalo SabresBuffalo Sabre | 2 - 6 | St. Louis BluesSt. Louis Blu |
| 16 Apr 22 | r00        | St. Louis BluesSt. Louis Blu | 6 - 5 | Minnesota WildMinnesota Wil |
| 17 Apr 22 | r00        | Nashville PredatorsNashville Pre | 3 - 8 | St. Louis BluesSt. Louis Blu |
| 20 Apr 22 | r00        | St. Louis BluesSt. Louis Blu | 2 - 3 | Boston BruinsBoston Bruins |
| 22 Apr 22 | r00        | San Jose SharksSan Jose Shar | 1 - 3 | St. Louis BluesSt. Louis Blu |
| 24 Apr 22 | r00        | Arizona CoyotesArizona Coyot | 4 - 5 | St. Louis BluesSt. Louis Blu |
| 25 Apr 22 | r00        | Anaheim DucksAnaheim Ducks | 3 - 6 | St. Louis BluesSt. Louis Blu |
| 27 Apr 22 | r00        | Colorado AvalancheColorado Aval | 5 - 3 | St. Louis BluesSt. Louis Blu |
| 30 Apr 22 | r00        | St. Louis BluesSt. Louis Blu | 4 - 7 | Vegas Golden KnightsVegas Golden |
| |
| 03 May 22 | Playoff        | Minnesota WildMinnesota Wil | 0 - 4 | St. Louis BluesSt. Louis Blu |
| 05 May 22 | Playoff        | Minnesota WildMinnesota Wil | 6 - 2 | St. Louis BluesSt. Louis Blu |
| 07 May 22 | Playoff        | St. Louis BluesSt. Louis Blu | 1 - 5 | Minnesota WildMinnesota Wil |
| 08 May 22 | Playoff        | St. Louis BluesSt. Louis Blu | 5 - 2 | Minnesota WildMinnesota Wil |
| 11 May 22 | Playoff        | Minnesota WildMinnesota Wil | 2 - 5 | St. Louis BluesSt. Louis Blu |
| 13 May 22 | Playoff        | St. Louis BluesSt. Louis Blu | 5 - 1 | Minnesota WildMinnesota Wil |
| |
| 18 May 22 | QF        | Colorado AvalancheColorado Aval | 3 - 2 | St. Louis BluesSt. Louis Blu |
| 20 May 22 | QF        | Colorado AvalancheColorado Aval | 1 - 4 | St. Louis BluesSt. Louis Blu |
| 22 May 22 | QF        | St. Louis BluesSt. Louis Blu | 2 - 5 | Colorado AvalancheColorado Aval |
| 24 May 22 | QF        | St. Louis BluesSt. Louis Blu | 3 - 6 | Colorado AvalancheColorado Aval |
| 26 May 22 | QF        | Colorado AvalancheColorado Aval | 4 - 5 | St. Louis BluesSt. Louis Blu |
| 28 May 22 | QF        | St. Louis BluesSt. Louis Blu | 2 - 3 | Colorado AvalancheColorado Aval |