| 29 Sep 21 |
r00        | Columbus Blue JacketsColumbus Blue | 4 - 5 | Buffalo SabresBuffalo Sabre |
| 01 Oct 21 |
r00        | Detroit Red WingsDetroit Red W | 6 - 2 | Buffalo SabresBuffalo Sabre |
| 02 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 1 - 2 | Pittsburgh PenguinsPittsburgh Pe |
| 05 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 5 | Columbus Blue JacketsColumbus Blue |
| 06 Oct 21 |
r00        | Pittsburgh PenguinsPittsburgh Pe | 5 - 4 | Buffalo SabresBuffalo Sabre |
| 09 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 1 | Detroit Red WingsDetroit Red W |
| 15 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 5 - 1 | Montreal CanadiensMontreal Cana |
| 16 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 2 - 1 | Arizona CoyotesArizona Coyot |
| 20 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 5 - 2 | Vancouver CanucksVancouver Can |
| 23 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 1 - 4 | Boston BruinsBoston Bruins |
| 24 Oct 21 |
r00        | New Jersey DevilsNew Jersey De | 2 - 1 | Buffalo SabresBuffalo Sabre |
| 26 Oct 21 |
r00        | Buffalo SabresBuffalo Sabre | 5 - 1 | Tampa Bay LightningTampa Bay Lig |
| 29 Oct 21 |
r00        | Anaheim DucksAnaheim Ducks | 3 - 4 | Buffalo SabresBuffalo Sabre |
| 31 Oct 21 |
r00        | Los Angeles KingsLos Angeles K | 3 - 2 | Buffalo SabresBuffalo Sabre |
| 03 Nov 21 |
r00        | San Jose SharksSan Jose Shar | 5 - 3 | Buffalo SabresBuffalo Sabre |
| 05 Nov 21 |
r00        | Seattle KrakenSeattle Krake | 5 - 2 | Buffalo SabresBuffalo Sabre |
| 06 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 4 | Detroit Red WingsDetroit Red W |
| 09 Nov 21 |
r00        | Washington CapitalsWashington Ca | 5 - 3 | Buffalo SabresBuffalo Sabre |
| 13 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 2 | Edmonton OilersEdmonton Oile |
| 14 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 5 | Toronto Maple LeafsToronto Maple |
| 17 Nov 21 |
r00        | Pittsburgh PenguinsPittsburgh Pe | 1 - 2 | Buffalo SabresBuffalo Sabre |
| 19 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 0 - 5 | Calgary FlamesCalgary Flame |
| 21 Nov 21 |
r00        | New York RangersNew York Rang | 5 - 4 | Buffalo SabresBuffalo Sabre |
| 23 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 7 | Columbus Blue JacketsColumbus Blue |
| 25 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 1 - 5 | Boston BruinsBoston Bruins |
| 27 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 1 | Montreal CanadiensMontreal Cana |
| 28 Nov 21 |
r00        | Detroit Red WingsDetroit Red W | 3 - 2 | Buffalo SabresBuffalo Sabre |
| 30 Nov 21 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 7 | Seattle KrakenSeattle Krake |
| 03 Dec 21 |
r00        | Florida PanthersFlorida Panth | 7 - 4 | Buffalo SabresBuffalo Sabre |
| 05 Dec 21 |
r00        | Carolina HurricanesCarolina Hurr | 6 - 2 | Buffalo SabresBuffalo Sabre |
| 08 Dec 21 |
r00        | Buffalo SabresBuffalo Sabre | 0 - 2 | Anaheim DucksAnaheim Ducks |
| 11 Dec 21 |
r00        | Buffalo SabresBuffalo Sabre | 1 - 2 | New York RangersNew York Rang |
| 12 Dec 21 |
r00        | Buffalo SabresBuffalo Sabre | 2 - 3 | Washington CapitalsWashington Ca |
| 15 Dec 21 |
r00        | Winnipeg JetsWinnipeg Jets | 2 - 4 | Buffalo SabresBuffalo Sabre |
| 17 Dec 21 |
r00        | Minnesota WildMinnesota Wil | 2 - 3 | Buffalo SabresBuffalo Sabre |
| 18 Dec 21 |
r00        | Pittsburgh PenguinsPittsburgh Pe | 3 - 2 | Buffalo SabresBuffalo Sabre |
| 30 Dec 21 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 4 | New Jersey DevilsNew Jersey De |
| 31 Dec 21 |
r00        | New York IslandersNew York Isla | 4 - 1 | Buffalo SabresBuffalo Sabre |
| 01 Jan 22 |
r00        | Boston BruinsBoston Bruins | 4 - 3 | Buffalo SabresBuffalo Sabre |
| 07 Jan 22 |
r00        | Buffalo SabresBuffalo Sabre | 2 - 3 | San Jose SharksSan Jose Shar |
| 12 Jan 22 |
r00        | Buffalo SabresBuffalo Sabre | 1 - 6 | Tampa Bay LightningTampa Bay Lig |
| 14 Jan 22 |
r00        | Nashville PredatorsNashville Pre | 1 - 4 | Buffalo SabresBuffalo Sabre |
| 16 Jan 22 |
r00        | Detroit Red WingsDetroit Red W | 4 - 0 | Buffalo SabresBuffalo Sabre |
| 17 Jan 22 |
r00        | Buffalo SabresBuffalo Sabre | 2 - 3 | Detroit Red WingsDetroit Red W |
| 19 Jan 22 |
r00        | Ottawa SenatorsOttawa Senato | 1 - 3 | Buffalo SabresBuffalo Sabre |
| 21 Jan 22 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 5 | Dallas StarsDallas Stars |
| 22 Jan 22 |
r00        | Buffalo SabresBuffalo Sabre | 6 - 3 | Philadelphia FlyersPhiladelphia |
| 26 Jan 22 |
r00        | Ottawa SenatorsOttawa Senato | 5 - 0 | Buffalo SabresBuffalo Sabre |
| 30 Jan 22 |
r00        | Arizona CoyotesArizona Coyot | 1 - 3 | Buffalo SabresBuffalo Sabre |
| 31 Jan 22 |
r00        | Colorado AvalancheColorado Aval | 4 - 1 | Buffalo SabresBuffalo Sabre |
| 02 Feb 22 |
r00        | Vegas Golden KnightsVegas Golden | 5 - 2 | Buffalo SabresBuffalo Sabre |
| 11 Feb 22 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 4 | Columbus Blue JacketsColumbus Blue |
| 13 Feb 22 |
r00        | Montreal CanadiensMontreal Cana | 3 - 5 | Buffalo SabresBuffalo Sabre |
| 16 Feb 22 |
r00        | Buffalo SabresBuffalo Sabre | 6 - 3 | New York IslandersNew York Isla |
| 18 Feb 22 |
r00        | Buffalo SabresBuffalo Sabre | 1 - 3 | Ottawa SenatorsOttawa Senato |
| 19 Feb 22 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 5 | Colorado AvalancheColorado Aval |
| 20 Feb 22 |
r00        | Columbus Blue JacketsColumbus Blue | 7 - 3 | Buffalo SabresBuffalo Sabre |
| 24 Feb 22 |
r00        | Montreal CanadiensMontreal Cana | 4 - 0 | Buffalo SabresBuffalo Sabre |
| 26 Feb 22 |
r00        | St. Louis BluesSt. Louis Blu | 5 - 3 | Buffalo SabresBuffalo Sabre |
| 27 Feb 22 |
r00        | Dallas StarsDallas Stars | 4 - 2 | Buffalo SabresBuffalo Sabre |
| 03 Mar 22 |
r00        | Toronto Maple LeafsToronto Maple | 1 - 5 | Buffalo SabresBuffalo Sabre |
| 05 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 5 - 4 | Minnesota WildMinnesota Wil |
| 06 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 0 - 3 | Los Angeles KingsLos Angeles K |
| 08 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 1 - 6 | Florida PanthersFlorida Panth |
| 11 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 1 | Vegas Golden KnightsVegas Golden |
| 13 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 5 - 2 | Toronto Maple LeafsToronto Maple |
| 18 Mar 22 |
r00        | Edmonton OilersEdmonton Oile | 6 - 1 | Buffalo SabresBuffalo Sabre |
| 19 Mar 22 |
r00        | Calgary FlamesCalgary Flame | 0 - 1 | Buffalo SabresBuffalo Sabre |
| 21 Mar 22 |
r00        | Vancouver CanucksVancouver Can | 2 - 3 | Buffalo SabresBuffalo Sabre |
| 23 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 3 | Pittsburgh PenguinsPittsburgh Pe |
| 25 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 4 | Washington CapitalsWashington Ca |
| 27 Mar 22 |
r00        | New York RangersNew York Rang | 5 - 4 | Buffalo SabresBuffalo Sabre |
| 29 Mar 22 |
r00        | Chicago BlackhawksChicago Black | 5 - 6 | Buffalo SabresBuffalo Sabre |
| 31 Mar 22 |
r00        | Buffalo SabresBuffalo Sabre | 2 - 3 | Winnipeg JetsWinnipeg Jets |
| 02 Apr 22 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 3 | Nashville PredatorsNashville Pre |
| 03 Apr 22 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 5 | Florida PanthersFlorida Panth |
| 06 Apr 22 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 2 | Carolina HurricanesCarolina Hurr |
| 08 Apr 22 |
r00        | Carolina HurricanesCarolina Hurr | 5 - 3 | Buffalo SabresBuffalo Sabre |
| 09 Apr 22 |
r00        | Florida PanthersFlorida Panth | 4 - 3 | Buffalo SabresBuffalo Sabre |
| 10 Apr 22 |
r00        | Tampa Bay LightningTampa Bay Lig | 5 - 0 | Buffalo SabresBuffalo Sabre |
| 13 Apr 22 |
r00        | Toronto Maple LeafsToronto Maple | 2 - 5 | Buffalo SabresBuffalo Sabre |
| 15 Apr 22 |
r00        | Buffalo SabresBuffalo Sabre | 2 - 6 | St. Louis BluesSt. Louis Blu |
| 17 Apr 22 |
r00        | Buffalo SabresBuffalo Sabre | 4 - 3 | Philadelphia FlyersPhiladelphia |
| 17 Apr 22 |
r00        | Philadelphia FlyersPhiladelphia | 3 - 5 | Buffalo SabresBuffalo Sabre |
| 22 Apr 22 |
r00        | New Jersey DevilsNew Jersey De | 2 - 5 | Buffalo SabresBuffalo Sabre |
| 23 Apr 22 |
r00        | Buffalo SabresBuffalo Sabre | 5 - 3 | New York IslandersNew York Isla |
| 29 Apr 22 |
r00        | Boston BruinsBoston Bruins | 5 - 0 | Buffalo SabresBuffalo Sabre |
| 30 Apr 22 |
r00        | Buffalo SabresBuffalo Sabre | 3 - 2 | Chicago BlackhawksChicago Black |