| 19 Nov 21 | r01        | Melbourne City FCMelbourne Cit | 2 - 1 | Brisbane Roar FCBrisbane Roar |
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| 27 Nov 21 | r02        | Adelaide UnitedAdelaide Unit | 2 - 2 | Melbourne City FCMelbourne Cit |
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| 04 Dec 21 | r03        | Melbourne City FCMelbourne Cit | 0 - 1 | Western United FCWestern Unite |
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| 08 Dec 21 | r04        | Melbourne City FCMelbourne Cit | 1 - 0 | Perth GloryPerth Glory |
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| 18 Dec 21 | r05        | Melbourne City FCMelbourne Cit | 2 - 2 | Melbourne VictoryMelbourne Vic |
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| 09 Jan 22 | r26        | Melbourne City FCMelbourne Cit | 3 - 3 | Western Sydney Wanderers Western Sydne |
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| 15 Jan 22 | r10        | Adelaide UnitedAdelaide Unit | 2 - 2 | Melbourne City FCMelbourne Cit |
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| 23 Jan 22 | r22        | Central Coast MarinersCentral Coast | 1 - 3 | Melbourne City FCMelbourne Cit |
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| 29 Jan 22 | r12        | Western United FCWestern Unite | 1 - 0 | Melbourne City FCMelbourne Cit |
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| 08 Feb 22 | r07        | Newcastle JetsNewcastle Jet | 2 - 4 | Melbourne City FCMelbourne Cit |
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| 11 Feb 22 | r14        | Western Sydney Wanderers Western Sydne | 1 - 3 | Melbourne City FCMelbourne Cit |
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| 15 Feb 22 | r24        | Melbourne City FCMelbourne Cit | 1 - 2 | Adelaide UnitedAdelaide Unit |
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| 18 Feb 22 | r15        | Melbourne City FCMelbourne Cit | 3 - 0 | Newcastle JetsNewcastle Jet |
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| 22 Feb 22 | r08        | Melbourne City FCMelbourne Cit | 3 - 2 | Central Coast MarinersCentral Coast |
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| 26 Feb 22 | r16        | Sydney FCSydney FC | 1 - 2 | Melbourne City FCMelbourne Cit |
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| 02 Mar 22 | r13        | Melbourne City FCMelbourne Cit | 2 - 2 | Perth GloryPerth Glory |
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| 09 Mar 22 | r09        | Melbourne City FCMelbourne Cit | 3 - 1 | Macarthur FCMacarthur FC |
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| 12 Mar 22 | r19        | Western United FCWestern Unite | 2 - 2 | Melbourne City FCMelbourne Cit |
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| 19 Mar 22 | r18        | Melbourne City FCMelbourne Cit | 1 - 1 | Melbourne VictoryMelbourne Vic |
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| 23 Mar 22 | r06        | Brisbane Roar FCBrisbane Roar | 1 - 2 | Melbourne City FCMelbourne Cit |
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| 26 Mar 22 | r20        | Macarthur FCMacarthur FC | 0 - 1 | Melbourne City FCMelbourne Cit |
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| 02 Apr 22 | r17        | Wellington PhoenixWellington Ph | 0 - 6 | Melbourne City FCMelbourne Cit |
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| 06 Apr 22 | r11        | Melbourne City FCMelbourne Cit | 4 - 0 | Sydney FCSydney FC |
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| 09 Apr 22 | r23        | Melbourne VictoryMelbourne Vic | 3 - 0 | Melbourne City FCMelbourne Cit |
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| 04 May 22 | r25        | Perth GloryPerth Glory | 2 - 0 | Melbourne City FCMelbourne Cit |
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| 09 May 22 | r21        | Melbourne City FCMelbourne Cit | 2 - 1 | Wellington PhoenixWellington Ph |
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| 18 May 22 | SF        | Adelaide UnitedAdelaide Unit | 0 - 0 | Melbourne City FCMelbourne Cit |
| 22 May 22 | SF        | Melbourne City FCMelbourne Cit | 2 - 1 | Adelaide UnitedAdelaide Unit |
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| 28 May 22 | Final        | Melbourne City FCMelbourne Cit | 0 - 2 | Western United FCWestern Unite |