| 20 Nov 21 | r01        | Perth GloryPerth Glory | 1 - 1 | Adelaide UnitedAdelaide Unit |
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| 26 Nov 21 | r02        | Western United FCWestern Unite | 1 - 0 | Perth GloryPerth Glory |
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| 05 Dec 21 | r03        | Melbourne VictoryMelbourne Vic | 0 - 3 | Perth GloryPerth Glory |
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| 08 Dec 21 | r04        | Melbourne City FCMelbourne Cit | 1 - 0 | Perth GloryPerth Glory |
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| 19 Jan 22 | r05        | Brisbane Roar FCBrisbane Roar | 1 - 0 | Perth GloryPerth Glory |
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| 22 Jan 22 | r07        | Sydney FCSydney FC | 1 - 2 | Perth GloryPerth Glory |
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| 02 Feb 22 | r09        | Western Sydney Wanderers Western Sydne | 1 - 0 | Perth GloryPerth Glory |
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| 13 Feb 22 | r14        | Central Coast MarinersCentral Coast | 1 - 1 | Perth GloryPerth Glory |
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| 20 Feb 22 | r15        | Perth GloryPerth Glory | 2 - 0 | Brisbane Roar FCBrisbane Roar |
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| 23 Feb 22 | r12        | Perth GloryPerth Glory | 0 - 1 | Macarthur FCMacarthur FC |
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| 27 Feb 22 | r16        | Perth GloryPerth Glory | 0 - 2 | Western United FCWestern Unite |
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| 02 Mar 22 | r13        | Melbourne City FCMelbourne Cit | 2 - 2 | Perth GloryPerth Glory |
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| 06 Mar 22 | r17        | Perth GloryPerth Glory | 1 - 2 | Adelaide UnitedAdelaide Unit |
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| 12 Mar 22 | r26        | Perth GloryPerth Glory | 0 - 2 | Sydney FCSydney FC |
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| 15 Mar 22 | r18        | Perth GloryPerth Glory | 0 - 0 | Central Coast MarinersCentral Coast |
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| 19 Mar 22 | r19        | Perth GloryPerth Glory | 1 - 4 | Brisbane Roar FCBrisbane Roar |
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| 26 Mar 22 | r20        | Wellington PhoenixWellington Ph | 2 - 1 | Perth GloryPerth Glory |
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| 30 Mar 22 | r11        | Perth GloryPerth Glory | 0 - 0 | Newcastle JetsNewcastle Jet |
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| 03 Apr 22 | r08        | Macarthur FCMacarthur FC | 4 - 2 | Perth GloryPerth Glory |
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| 06 Apr 22 | r22        | Perth GloryPerth Glory | 0 - 1 | Melbourne VictoryMelbourne Vic |
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| 10 Apr 22 | r23        | Newcastle JetsNewcastle Jet | 6 - 1 | Perth GloryPerth Glory |
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| 13 Apr 22 | r10        | Perth GloryPerth Glory | 0 - 1 | Wellington PhoenixWellington Ph |
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| 16 Apr 22 | r24        | Western United FCWestern Unite | 6 - 0 | Perth GloryPerth Glory |
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| 24 Apr 22 | r06        | Adelaide UnitedAdelaide Unit | 2 - 0 | Perth GloryPerth Glory |
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| 30 Apr 22 | r21        | Perth GloryPerth Glory | 1 - 1 | Western Sydney Wanderers Western Sydne |
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| 04 May 22 | r25        | Perth GloryPerth Glory | 2 - 0 | Melbourne City FCMelbourne Cit |