| 20 Jan 21 | r04        | Perth GloryPerth Glory | 5 - 3 | Adelaide UnitedAdelaide Unit |
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| 23 Jan 21 | r05        | Western United FCWestern Unite | 5 - 4 | Perth GloryPerth Glory |
| 26 Jan 21 | r05        | Melbourne VictoryMelbourne Vic | 2 - 1 | Perth GloryPerth Glory |
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| 31 Jan 21 | r06        | Melbourne City FCMelbourne Cit | 1 - 3 | Perth GloryPerth Glory |
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| 05 Feb 21 | r07        | Adelaide UnitedAdelaide Unit | 1 - 2 | Perth GloryPerth Glory |
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| 26 Feb 21 | r10        | Perth GloryPerth Glory | 3 - 1 | Brisbane Roar FCBrisbane Roar |
| 02 Mar 21 | r10        | Perth GloryPerth Glory | 1 - 2 | Central Coast MarinersCentral Coast |
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| 07 Mar 21 | r11        | Wellington PhoenixWellington Ph | 3 - 0 | Perth GloryPerth Glory |
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| 14 Mar 21 | r12        | Central Coast MarinersCentral Coast | 2 - 2 | Perth GloryPerth Glory |
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| 19 Mar 21 | r13        | Western Sydney Wanderers Western Sydne | 3 - 0 | Perth GloryPerth Glory |
| 24 Mar 21 | r13        | Perth GloryPerth Glory | 1 - 1 | Sydney FCSydney FC |
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| 27 Mar 21 | r14        | Perth GloryPerth Glory | 2 - 1 | Newcastle JetsNewcastle Jet |
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| 02 Apr 21 | r15        | Macarthur FCMacarthur FC | 2 - 0 | Perth GloryPerth Glory |
| 07 Apr 21 | r15        | Sydney FCSydney FC | 1 - 0 | Perth GloryPerth Glory |
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| 13 Apr 21 | r16        | Newcastle JetsNewcastle Jet | 1 - 1 | Perth GloryPerth Glory |
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| 18 Apr 21 | r17        | Perth GloryPerth Glory | 1 - 3 | Wellington PhoenixWellington Ph |
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| 01 May 21 | r19        | Perth GloryPerth Glory | 0 - 0 | Macarthur FCMacarthur FC |
| 05 May 21 | r19        | Perth GloryPerth Glory | 1 - 3 | Melbourne City FCMelbourne Cit |
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| 09 May 21 | r20        | Perth GloryPerth Glory | 2 - 1 | Melbourne VictoryMelbourne Vic |
| 12 May 21 | r20        | Perth GloryPerth Glory | 3 - 0 | Western United FCWestern Unite |
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| 16 May 21 | r21        | Perth GloryPerth Glory | 5 - 1 | Western Sydney Wanderers Western Sydne |
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| 19 May 21 | r20        | Perth GloryPerth Glory | 2 - 1 | Adelaide UnitedAdelaide Unit |
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| 23 May 21 | r10        | Perth GloryPerth Glory | 1 - 1 | Macarthur FCMacarthur FC |
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| 30 May 21 | r05        | Wellington PhoenixWellington Ph | 2 - 2 | Perth GloryPerth Glory |
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| 02 Jun 21 | r18        | Brisbane Roar FCBrisbane Roar | 2 - 1 | Perth GloryPerth Glory |
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| 05 Jun 21 | r06        | Newcastle JetsNewcastle Jet | 1 - 1 | Perth GloryPerth Glory |