| 23 Jul 21 | r01   | FC LvivFC Lviv | 1 - 1 | MariupolMariupol |
| 24 Jul 21 | r01 | Veres RivneVeres Rivne | 0 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| 24 Jul 21 | r01  | Shakhtar DonetskShakhtar Done | 2 - 1 | InhuletsInhulets |
| 25 Jul 21 | r01 | FC Metalist KharkivFC Metalist K | 2 - 1 | Rukh LvivRukh Lviv |
| 25 Jul 21 | r01 | ZoryaZorya | 0 - 1 | FC OlexandriaFC Olexandria |
| 25 Jul 21 | r01 | DesnaDesna | 3 - 0 | ChornomoretsChornomorets |
| 26 Jul 21 | r01 | VorsklaVorskla | 2 - 2 | SC Dnipro-1SC Dnipro-1 |
| |
| 30 Jul 21 | r02  | FC LvivFC Lviv | 0 - 3 | Shakhtar DonetskShakhtar Done |
| 30 Jul 21 | r02 | FC Kolos KovalivkaFC Kolos Kova | 1 - 0 | FC Metalist KharkivFC Metalist K |
| 31 Jul 21 | r02 | MynaiMynai | 1 - 0 | FC OlexandriaFC Olexandria |
| 31 Jul 21 | r02 | ChornomoretsChornomorets | 0 - 3 | SC Dnipro-1SC Dnipro-1 |
| 01 Aug 21 | r02 | MariupolMariupol | 1 - 2 | DesnaDesna |
| 01 Aug 21 | r02 | Dynamo KievDynamo Kiev | 4 - 0 | Veres RivneVeres Rivne |
| 01 Aug 21 | r02 | VorsklaVorskla | 2 - 0 | Rukh LvivRukh Lviv |
| 02 Aug 21 | r02 | InhuletsInhulets | 1 - 5 | ZoryaZorya |
| |
| 06 Aug 21 | r03 | FC Metalist KharkivFC Metalist K | 3 - 2 | ChornomoretsChornomorets |
| 07 Aug 21 | r03 | Rukh LvivRukh Lviv | 2 - 1 | Veres RivneVeres Rivne |
| 07 Aug 21 | r03 | Shakhtar DonetskShakhtar Done | 1 - 2 | FC OlexandriaFC Olexandria |
| 07 Aug 21 | r03 | SC Dnipro-1SC Dnipro-1 | 2 - 1 | MariupolMariupol |
| 08 Aug 21 | r03 | ZoryaZorya | 1 - 2 | Dynamo KievDynamo Kiev |
| 08 Aug 21 | r03 | VorsklaVorskla | 4 - 1 | FC LvivFC Lviv |
| 09 Aug 21 | r03 | DesnaDesna | 2 - 0 | InhuletsInhulets |
| |
| 11 Aug 21 | r01 | Dynamo KievDynamo Kiev | 2 - 0 | MynaiMynai |
| |
| 13 Aug 21 | r04 | Shakhtar DonetskShakhtar Done | 2 - 0 | FC Metalist KharkivFC Metalist K |
| 14 Aug 21 | r04 | Veres RivneVeres Rivne | 1 - 1 | VorsklaVorskla |
| 14 Aug 21 | r04 | DesnaDesna | 2 - 1 | SC Dnipro-1SC Dnipro-1 |
| 14 Aug 21 | r04 | ZoryaZorya | 1 - 1 | MynaiMynai |
| 15 Aug 21 | r04 | FC Kolos KovalivkaFC Kolos Kova | 1 - 1 | Rukh LvivRukh Lviv |
| 15 Aug 21 | r04 | FC LvivFC Lviv | 1 - 1 | FC OlexandriaFC Olexandria |
| 16 Aug 21 | r04 | MariupolMariupol | 2 - 3 | ChornomoretsChornomorets |
| 18 Aug 21 | r04 | InhuletsInhulets | 1 - 1 | Dynamo KievDynamo Kiev |
| |
| 20 Aug 21 | r05 | VorsklaVorskla | 2 - 0 | FC Metalist KharkivFC Metalist K |
| 21 Aug 21 | r05 | Veres RivneVeres Rivne | 1 - 0 | MynaiMynai |
| 21 Aug 21 | r05 | ChornomoretsChornomorets | 0 - 3 | Shakhtar DonetskShakhtar Done |
| 21 Aug 21 | r05 | SC Dnipro-1SC Dnipro-1 | 2 - 0 | Rukh LvivRukh Lviv |
| 22 Aug 21 | r05 | MariupolMariupol | 3 - 4 | ZoryaZorya |
| 22 Aug 21 | r05 | FC Kolos KovalivkaFC Kolos Kova | 0 - 1 | FC OlexandriaFC Olexandria |
| 22 Aug 21 | r05 | Dynamo KievDynamo Kiev | 4 - 0 | DesnaDesna |
| 23 Aug 21 | r05 | FC LvivFC Lviv | 1 - 2 | InhuletsInhulets |
| |
| 27 Aug 21 | r06 | ChornomoretsChornomorets | 2 - 2 | FC OlexandriaFC Olexandria |
| 28 Aug 21 | r06 | InhuletsInhulets | 3 - 0 | MariupolMariupol |
| 28 Aug 21 | r06 | FC Metalist KharkivFC Metalist K | 1 - 2 | SC Dnipro-1SC Dnipro-1 |
| 28 Aug 21 | r06 | Dynamo KievDynamo Kiev | 7 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| 29 Aug 21 | r06 | DesnaDesna | 0 - 4 | Veres RivneVeres Rivne |
| 29 Aug 21 | r06 | MynaiMynai | 1 - 1 | Shakhtar DonetskShakhtar Done |
| 29 Aug 21 | r06 | ZoryaZorya | 1 - 0 | VorsklaVorskla |
| 29 Aug 21 | r06 | Rukh LvivRukh Lviv | 1 - 0 | FC LvivFC Lviv |
| |
| 10 Sep 21 | r07 | FC OlexandriaFC Olexandria | 1 - 0 | InhuletsInhulets |
| 11 Sep 21 | r07 | Rukh LvivRukh Lviv | 1 - 1 | ZoryaZorya |
| 11 Sep 21 | r07 | FC Metalist KharkivFC Metalist K | 0 - 2 | Dynamo KievDynamo Kiev |
| 11 Sep 21 | r07 | Shakhtar DonetskShakhtar Done | 2 - 0 | SC Dnipro-1SC Dnipro-1 |
| 12 Sep 21 | r07 | MynaiMynai | 2 - 2 | ChornomoretsChornomorets |
| 12 Sep 21 | r07 | FC Kolos KovalivkaFC Kolos Kova | 1 - 3 | MariupolMariupol |
| 12 Sep 21 | r07 | VorsklaVorskla | 2 - 2 | DesnaDesna |
| 13 Sep 21 | r07 | Veres RivneVeres Rivne | 1 - 0 | FC LvivFC Lviv |
| |
| 17 Sep 21 | r08 | DesnaDesna | 1 - 0 | Rukh LvivRukh Lviv |
| 18 Sep 21 | r08 | InhuletsInhulets | 0 - 2 | FC Kolos KovalivkaFC Kolos Kova |
| 18 Sep 21 | r08 | MariupolMariupol | 0 - 5 | Shakhtar DonetskShakhtar Done |
| 18 Sep 21 | r08 | SC Dnipro-1SC Dnipro-1 | 1 - 0 | Veres RivneVeres Rivne |
| 18 Sep 21 | r08 | Dynamo KievDynamo Kiev | 1 - 0 | FC OlexandriaFC Olexandria |
| 19 Sep 21 | r08 | VorsklaVorskla | 2 - 0 | MynaiMynai |
| 19 Sep 21 | r08 | ZoryaZorya | 3 - 0 | ChornomoretsChornomorets |
| 19 Sep 21 | r08 | FC LvivFC Lviv | 0 - 0 | FC Metalist KharkivFC Metalist K |
| |
| 24 Sep 21 | r09 | FC Kolos KovalivkaFC Kolos Kova | 0 - 1 | VorsklaVorskla |
| 25 Sep 21 | r09 | FC OlexandriaFC Olexandria | 2 - 1 | MariupolMariupol |
| 25 Sep 21 | r09 | Shakhtar DonetskShakhtar Done | 4 - 1 | Veres RivneVeres Rivne |
| 25 Sep 21 | r09 | Rukh LvivRukh Lviv | 0 - 2 | Dynamo KievDynamo Kiev |
| 26 Sep 21 | r09 | MynaiMynai | 1 - 2 | FC LvivFC Lviv |
| 26 Sep 21 | r09 | SC Dnipro-1SC Dnipro-1 | 0 - 4 | ZoryaZorya |
| 26 Sep 21 | r09 | DesnaDesna | 1 - 2 | FC Metalist KharkivFC Metalist K |
| 27 Sep 21 | r09 | ChornomoretsChornomorets | 1 - 1 | InhuletsInhulets |
| |
| 01 Oct 21 | r10 | MariupolMariupol | 0 - 2 | Rukh LvivRukh Lviv |
| 02 Oct 21 | r10 | FC Kolos KovalivkaFC Kolos Kova | 2 - 1 | ChornomoretsChornomorets |
| 02 Oct 21 | r10 | FC LvivFC Lviv | 0 - 1 | SC Dnipro-1SC Dnipro-1 |
| 02 Oct 21 | r10 | VorsklaVorskla | 3 - 0 | InhuletsInhulets |
| 03 Oct 21 | r10 | Veres RivneVeres Rivne | 0 - 0 | FC OlexandriaFC Olexandria |
| 03 Oct 21 | r10 | ZoryaZorya | 2 - 0 | DesnaDesna |
| 03 Oct 21 | r10 | FC Metalist KharkivFC Metalist K | 1 - 0 | MynaiMynai |
| 03 Oct 21 | r10 | Dynamo KievDynamo Kiev | 0 - 0 | Shakhtar DonetskShakhtar Done |
| |
| 15 Oct 21 | r11 | Shakhtar DonetskShakhtar Done | 6 - 1 | ZoryaZorya |
| 16 Oct 21 | r11 | MariupolMariupol | 1 - 2 | FC Metalist KharkivFC Metalist K |
| 16 Oct 21 | r11 | FC LvivFC Lviv | 1 - 4 | Dynamo KievDynamo Kiev |
| 16 Oct 21 | r11 | SC Dnipro-1SC Dnipro-1 | 2 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| 17 Oct 21 | r11 | MynaiMynai | 0 - 0 | DesnaDesna |
| 17 Oct 21 | r11 | FC OlexandriaFC Olexandria | 1 - 2 | VorsklaVorskla |
| 18 Oct 21 | r11 | ChornomoretsChornomorets | 0 - 1 | Veres RivneVeres Rivne |
| |
| 22 Oct 21 | r12 | DesnaDesna | 1 - 1 | FC OlexandriaFC Olexandria |
| 22 Oct 21 | r12 | FC Metalist KharkivFC Metalist K | 4 - 0 | InhuletsInhulets |
| 23 Oct 21 | r12 | Veres RivneVeres Rivne | 2 - 0 | MariupolMariupol |
| 23 Oct 21 | r12 | VorsklaVorskla | 0 - 2 | Shakhtar DonetskShakhtar Done |
| 23 Oct 21 | r12 | ChornomoretsChornomorets | 1 - 1 | FC LvivFC Lviv |
| 24 Oct 21 | r12 | Rukh LvivRukh Lviv | 2 - 2 | MynaiMynai |
| 24 Oct 21 | r12 | Dynamo KievDynamo Kiev | 2 - 0 | SC Dnipro-1SC Dnipro-1 |
| 24 Oct 21 | r12 | ZoryaZorya | 1 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| |
| 30 Oct 21 | r13 | MariupolMariupol | 2 - 3 | Dynamo KievDynamo Kiev |
| 30 Oct 21 | r13 | Shakhtar DonetskShakhtar Done | 4 - 1 | DesnaDesna |
| 30 Oct 21 | r13 | InhuletsInhulets | 0 - 0 | Veres RivneVeres Rivne |
| 31 Oct 21 | r13 | FC Kolos KovalivkaFC Kolos Kova | 0 - 1 | FC LvivFC Lviv |
| 31 Oct 21 | r13 | Rukh LvivRukh Lviv | 0 - 0 | FC OlexandriaFC Olexandria |
| 31 Oct 21 | r13 | FC Metalist KharkivFC Metalist K | 1 - 6 | ZoryaZorya |
| 01 Nov 21 | r13 | SC Dnipro-1SC Dnipro-1 | 4 - 0 | MynaiMynai |
| 01 Nov 21 | r13 | VorsklaVorskla | 0 - 0 | ChornomoretsChornomorets |
| |
| 05 Nov 21 | r14 | FC OlexandriaFC Olexandria | 2 - 0 | FC Metalist KharkivFC Metalist K |
| 06 Nov 21 | r14 | MynaiMynai | 0 - 2 | MariupolMariupol |
| 06 Nov 21 | r14 | Dynamo KievDynamo Kiev | 1 - 2 | VorsklaVorskla |
| 06 Nov 21 | r14 | ChornomoretsChornomorets | 4 - 3 | Rukh LvivRukh Lviv |
| 07 Nov 21 | r14 | InhuletsInhulets | 0 - 1 | SC Dnipro-1SC Dnipro-1 |
| 07 Nov 21 | r14 | FC Kolos KovalivkaFC Kolos Kova | 1 - 3 | Shakhtar DonetskShakhtar Done |
| 07 Nov 21 | r14 | ZoryaZorya | 3 - 0 | Veres RivneVeres Rivne |
| 07 Nov 21 | r14 | FC LvivFC Lviv | 0 - 2 | DesnaDesna |
| |
| 19 Nov 21 | r15 | ChornomoretsChornomorets | 1 - 6 | Dynamo KievDynamo Kiev |
| 20 Nov 21 | r15 | FC LvivFC Lviv | 2 - 1 | ZoryaZorya |
| 20 Nov 21 | r15 | Shakhtar DonetskShakhtar Done | 2 - 0 | Rukh LvivRukh Lviv |
| 20 Nov 21 | r15 | SC Dnipro-1SC Dnipro-1 | 3 - 1 | FC OlexandriaFC Olexandria |
| 21 Nov 21 | r15 | MynaiMynai | 2 - 2 | InhuletsInhulets |
| 21 Nov 21 | r15 | VorsklaVorskla | 5 - 1 | MariupolMariupol |
| 21 Nov 21 | r15 | DesnaDesna | 0 - 1 | FC Kolos KovalivkaFC Kolos Kova |
| 22 Nov 21 | r15 | Veres RivneVeres Rivne | 2 - 0 | FC Metalist KharkivFC Metalist K |
| |
| 24 Nov 21 | r03 | MynaiMynai | 1 - 1 | FC Kolos KovalivkaFC Kolos Kova |
| |
| 26 Nov 21 | r16 | MariupolMariupol | 0 - 1 | FC LvivFC Lviv |
| 27 Nov 21 | r16 | MynaiMynai | 0 - 2 | Dynamo KievDynamo Kiev |
| 27 Nov 21 | r16 | ChornomoretsChornomorets | 0 - 1 | DesnaDesna |
| 27 Nov 21 | r16 | SC Dnipro-1SC Dnipro-1 | 5 - 1 | VorsklaVorskla |
| 28 Nov 21 | r16 | InhuletsInhulets | 0 - 1 | Shakhtar DonetskShakhtar Done |
| 28 Nov 21 | r16 | Rukh LvivRukh Lviv | 2 - 0 | FC Metalist KharkivFC Metalist K |
| 28 Nov 21 | r16 | FC Kolos KovalivkaFC Kolos Kova | 1 - 0 | Veres RivneVeres Rivne |
| 29 Nov 21 | r16 | FC OlexandriaFC Olexandria | 0 - 1 | ZoryaZorya |
| |
| 03 Dec 21 | r17 | Shakhtar DonetskShakhtar Done | 6 - 1 | FC LvivFC Lviv |
| 04 Dec 21 | r17 | Veres RivneVeres Rivne | 0 - 3 | Dynamo KievDynamo Kiev |
| 04 Dec 21 | r17 | Rukh LvivRukh Lviv | 0 - 0 | VorsklaVorskla |
| 04 Dec 21 | r17 | FC Metalist KharkivFC Metalist K | 0 - 1 | FC Kolos KovalivkaFC Kolos Kova |
| 05 Dec 21 | r17 | ZoryaZorya | 1 - 0 | InhuletsInhulets |
| 05 Dec 21 | r17 | FC OlexandriaFC Olexandria | 3 - 0 | MynaiMynai |
| 05 Dec 21 | r17 | DesnaDesna | 3 - 3 | MariupolMariupol |
| 06 Dec 21 | r17 | SC Dnipro-1SC Dnipro-1 | 3 - 1 | ChornomoretsChornomorets |
| |
| 10 Dec 21 | r18 | MariupolMariupol | 0 - 3 | SC Dnipro-1SC Dnipro-1 |
| 10 Dec 21 | r18 | InhuletsInhulets | 2 - 1 | DesnaDesna |
| 11 Dec 21 | r18 | FC OlexandriaFC Olexandria | 1 - 2 | Shakhtar DonetskShakhtar Done |
| 11 Dec 21 | r18 | Veres RivneVeres Rivne | 1 - 1 | Rukh LvivRukh Lviv |
| 11 Dec 21 | r18 | FC LvivFC Lviv | 1 - 1 | VorsklaVorskla |
| 12 Dec 21 | r18 | ChornomoretsChornomorets | 2 - 1 | FC Metalist KharkivFC Metalist K |
| 12 Dec 21 | r18 | Dynamo KievDynamo Kiev | 1 - 1 | ZoryaZorya |
| 12 Dec 21 | r18 | FC Kolos KovalivkaFC Kolos Kova | 2 - 1 | MynaiMynai |
| |
| 16 Dec 21 | r11 | InhuletsInhulets | - | Rukh LvivRukh Lviv |
| |
| 25 Feb 22 | r19 | Olimpik DonetskOlimpik Donet | - | ZoryaZorya |
| 26 Feb 22 | r19 | Dynamo KievDynamo Kiev | - | InhuletsInhulets |
| 26 Feb 22 | r19 | FC Metalist KharkivFC Metalist K | - | Shakhtar DonetskShakhtar Done |
| 26 Feb 22 | r19 | FC OlexandriaFC Olexandria | - | FC LvivFC Lviv |
| 27 Feb 22 | r19 | VorsklaVorskla | - | Veres RivneVeres Rivne |
| 27 Feb 22 | r19 | ChornomoretsChornomorets | - | MariupolMariupol |
| 27 Feb 22 | r19 | SC Dnipro-1SC Dnipro-1 | - | DesnaDesna |
| 28 Feb 22 | r19 | Rukh LvivRukh Lviv | - | FC Kolos KovalivkaFC Kolos Kova |
| |
| 05 Mar 22 | r20 | MynaiMynai | - | Veres RivneVeres Rivne |
| 05 Mar 22 | r20 | FC OlexandriaFC Olexandria | - | FC Kolos KovalivkaFC Kolos Kova |
| 05 Mar 22 | r20 | ZoryaZorya | - | MariupolMariupol |
| 06 Mar 22 | r20 | InhuletsInhulets | - | FC LvivFC Lviv |
| 06 Mar 22 | r20 | Shakhtar DonetskShakhtar Done | - | ChornomoretsChornomorets |
| 06 Mar 22 | r20 | DesnaDesna | - | Dynamo KievDynamo Kiev |
| 07 Mar 22 | r20 | Rukh LvivRukh Lviv | - | SC Dnipro-1SC Dnipro-1 |
| 07 Mar 22 | r20 | FC Metalist KharkivFC Metalist K | - | VorsklaVorskla |
| |
| 11 Mar 22 | r21 | MariupolMariupol | - | InhuletsInhulets |
| 12 Mar 22 | r21 | SC Dnipro-1SC Dnipro-1 | - | FC Metalist KharkivFC Metalist K |
| 12 Mar 22 | r21 | Shakhtar DonetskShakhtar Done | - | MynaiMynai |
| 12 Mar 22 | r21 | FC Kolos KovalivkaFC Kolos Kova | - | Dynamo KievDynamo Kiev |
| 13 Mar 22 | r21 | Veres RivneVeres Rivne | - | DesnaDesna |
| 13 Mar 22 | r21 | FC LvivFC Lviv | - | Rukh LvivRukh Lviv |
| 13 Mar 22 | r21 | VorsklaVorskla | - | ZoryaZorya |
| 14 Mar 22 | r21 | FC OlexandriaFC Olexandria | - | ChornomoretsChornomorets |
| |
| 16 Mar 22 | r22 | SC Dnipro-1SC Dnipro-1 | - | Shakhtar DonetskShakhtar Done |
| 17 Mar 22 | r22 | Dynamo KievDynamo Kiev | - | FC Metalist KharkivFC Metalist K |
| 17 Mar 22 | r22 | DesnaDesna | - | VorsklaVorskla |
| 18 Mar 22 | r22 | ZoryaZorya | - | Rukh LvivRukh Lviv |
| 19 Mar 22 | r22 | MariupolMariupol | - | FC Kolos KovalivkaFC Kolos Kova |
| 19 Mar 22 | r22 | ChornomoretsChornomorets | - | MynaiMynai |
| 20 Mar 22 | r22 | InhuletsInhulets | - | FC OlexandriaFC Olexandria |
| 20 Mar 22 | r22 | FC LvivFC Lviv | - | Veres RivneVeres Rivne |
| |
| 02 Apr 22 | r23 | FC Kolos KovalivkaFC Kolos Kova | - | InhuletsInhulets |
| 02 Apr 22 | r23 | FC Metalist KharkivFC Metalist K | - | FC LvivFC Lviv |
| 02 Apr 22 | r23 | Veres RivneVeres Rivne | - | SC Dnipro-1SC Dnipro-1 |
| 02 Apr 22 | r23 | Rukh LvivRukh Lviv | - | DesnaDesna |
| 02 Apr 22 | r23 | ChornomoretsChornomorets | - | ZoryaZorya |
| 02 Apr 22 | r23 | Shakhtar DonetskShakhtar Done | - | MariupolMariupol |
| 02 Apr 22 | r23 | FC OlexandriaFC Olexandria | - | Dynamo KievDynamo Kiev |
| 02 Apr 22 | r23 | MynaiMynai | - | VorsklaVorskla |
| |
| 09 Apr 22 | r24 | InhuletsInhulets | - | ChornomoretsChornomorets |
| 09 Apr 22 | r24 | MariupolMariupol | - | FC OlexandriaFC Olexandria |
| 09 Apr 22 | r24 | FC Metalist KharkivFC Metalist K | - | DesnaDesna |
| 09 Apr 22 | r24 | VorsklaVorskla | - | FC Kolos KovalivkaFC Kolos Kova |
| 09 Apr 22 | r24 | ZoryaZorya | - | SC Dnipro-1SC Dnipro-1 |
| 09 Apr 22 | r24 | Veres RivneVeres Rivne | - | Shakhtar DonetskShakhtar Done |
| 09 Apr 22 | r24 | Dynamo KievDynamo Kiev | - | Rukh LvivRukh Lviv |
| 09 Apr 22 | r24 | FC LvivFC Lviv | - | MynaiMynai |
| |
| 16 Apr 22 | r25 | Rukh LvivRukh Lviv | - | MariupolMariupol |
| 16 Apr 22 | r25 | FC OlexandriaFC Olexandria | - | Veres RivneVeres Rivne |
| 16 Apr 22 | r25 | SC Dnipro-1SC Dnipro-1 | - | FC LvivFC Lviv |
| 16 Apr 22 | r25 | InhuletsInhulets | - | VorsklaVorskla |
| 16 Apr 22 | r25 | ChornomoretsChornomorets | - | FC Kolos KovalivkaFC Kolos Kova |
| 16 Apr 22 | r25 | DesnaDesna | - | ZoryaZorya |
| 16 Apr 22 | r25 | Shakhtar DonetskShakhtar Done | - | Dynamo KievDynamo Kiev |
| 16 Apr 22 | r25 | MynaiMynai | - | FC Metalist KharkivFC Metalist K |
| |
| 23 Apr 22 | r26 | FC Kolos KovalivkaFC Kolos Kova | - | SC Dnipro-1SC Dnipro-1 |
| 23 Apr 22 | r26 | Veres RivneVeres Rivne | - | ChornomoretsChornomorets |
| 23 Apr 22 | r26 | FC Metalist KharkivFC Metalist K | - | MariupolMariupol |
| 23 Apr 22 | r26 | Rukh LvivRukh Lviv | - | InhuletsInhulets |
| 23 Apr 22 | r26 | VorsklaVorskla | - | FC OlexandriaFC Olexandria |
| 23 Apr 22 | r26 | ZoryaZorya | - | Shakhtar DonetskShakhtar Done |
| 23 Apr 22 | r26 | Dynamo KievDynamo Kiev | - | FC LvivFC Lviv |
| 23 Apr 22 | r26 | DesnaDesna | - | MynaiMynai |
| |
| 30 Apr 22 | r27 | FC Kolos KovalivkaFC Kolos Kova | - | ZoryaZorya |
| 30 Apr 22 | r27 | InhuletsInhulets | - | FC Metalist KharkivFC Metalist K |
| 30 Apr 22 | r27 | MariupolMariupol | - | Veres RivneVeres Rivne |
| 30 Apr 22 | r27 | FC LvivFC Lviv | - | ChornomoretsChornomorets |
| 30 Apr 22 | r27 | FC OlexandriaFC Olexandria | - | DesnaDesna |
| 30 Apr 22 | r27 | Shakhtar DonetskShakhtar Done | - | VorsklaVorskla |
| 30 Apr 22 | r27 | SC Dnipro-1SC Dnipro-1 | - | Dynamo KievDynamo Kiev |
| 30 Apr 22 | r27 | MynaiMynai | - | Rukh LvivRukh Lviv |
| |
| 07 May 22 | r28 | Veres RivneVeres Rivne | - | InhuletsInhulets |
| 07 May 22 | r28 | FC OlexandriaFC Olexandria | - | Rukh LvivRukh Lviv |
| 07 May 22 | r28 | ChornomoretsChornomorets | - | VorsklaVorskla |
| 07 May 22 | r28 | FC LvivFC Lviv | - | FC Kolos KovalivkaFC Kolos Kova |
| 07 May 22 | r28 | ZoryaZorya | - | FC Metalist KharkivFC Metalist K |
| 07 May 22 | r28 | DesnaDesna | - | Shakhtar DonetskShakhtar Done |
| 07 May 22 | r28 | Dynamo KievDynamo Kiev | - | MariupolMariupol |
| 07 May 22 | r28 | MynaiMynai | - | SC Dnipro-1SC Dnipro-1 |
| |
| 14 May 22 | r29 | Rukh LvivRukh Lviv | - | ChornomoretsChornomorets |
| 14 May 22 | r29 | FC Metalist KharkivFC Metalist K | - | FC OlexandriaFC Olexandria |
| 14 May 22 | r29 | SC Dnipro-1SC Dnipro-1 | - | InhuletsInhulets |
| 14 May 22 | r29 | DesnaDesna | - | FC LvivFC Lviv |
| 14 May 22 | r29 | Veres RivneVeres Rivne | - | ZoryaZorya |
| 14 May 22 | r29 | Shakhtar DonetskShakhtar Done | - | FC Kolos KovalivkaFC Kolos Kova |
| 14 May 22 | r29 | VorsklaVorskla | - | Dynamo KievDynamo Kiev |
| 14 May 22 | r29 | MariupolMariupol | - | MynaiMynai |
| |
| 21 May 22 | r30 | FC Kolos KovalivkaFC Kolos Kova | - | DesnaDesna |
| 21 May 22 | r30 | FC OlexandriaFC Olexandria | - | SC Dnipro-1SC Dnipro-1 |
| 21 May 22 | r30 | MariupolMariupol | - | VorsklaVorskla |
| 21 May 22 | r30 | ZoryaZorya | - | FC LvivFC Lviv |
| 21 May 22 | r30 | Rukh LvivRukh Lviv | - | Shakhtar DonetskShakhtar Done |
| 21 May 22 | r30 | Dynamo KievDynamo Kiev | - | ChornomoretsChornomorets |
| 21 May 22 | r30 | FC Metalist KharkivFC Metalist K | - | Veres RivneVeres Rivne |
| 21 May 22 | r30 | InhuletsInhulets | - | MynaiMynai |
Team 2021-2022 Schedules
Bukovyna Chernivtsi
Chornomorets Odesa
Dynamo Kyiv
Epitsentr Kamianets-Podilsky
Karpaty Lviv
Kharkiv
Kolos Kovalivka
Kryvbas Kryvyi Rih
Kudrivka
Livyi Bereh Kyiv
LNZ Cherkasy
Obolon Kyiv
Polissya Zhytomyr
Shakhtar Donetsk
Veres Rivne
Zorya Luhansk
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