| 03 Jul 22 | r01      | CF AmericaCF America | 0 - 0 | AtlasAtlas |
| |
| 10 Jul 22 | r02 | MonterreyMonterrey | 3 - 2 | CF AmericaCF America |
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| 14 Jul 22 | r03 | CF AmericaCF America | 1 - 0 | TolucaToluca |
| |
| 24 Jul 22 | r04 | TijuanaTijuana | 2 - 0 | CF AmericaCF America |
| |
| 01 Aug 22 | r06 | LeonLeon | 3 - 2 | CF AmericaCF America |
| |
| 08 Aug 22 | r07 | CF AmericaCF America | 2 - 1 | FC JuarezFC Juarez |
| |
| 14 Aug 22 | r08 | PumasPumas | 0 - 3 | CF AmericaCF America |
| |
| 18 Aug 22 | r09 | PachucaPachuca | 0 - 3 | CF AmericaCF America |
| |
| 21 Aug 22 | r10 | CF AmericaCF America | 7 - 0 | Cruz AzulCruz Azul |
| |
| 24 Aug 22 | r16 | Queretaro FCQueretaro FC | 0 - 1 | CF AmericaCF America |
| |
| 27 Aug 22 | r11 | MazatlánMazatlán | 1 - 3 | CF AmericaCF America |
| |
| 04 Sep 22 | r12 | CF AmericaCF America | 2 - 1 | TigresTigres |
| |
| 07 Sep 22 | r13 | CF AmericaCF America | 3 - 0 | Atletico de San LuisAtletico de S |
| |
| 11 Sep 22 | r14 | NecaxaNecaxa | 1 - 2 | CF AmericaCF America |
| |
| 15 Sep 22 | r05 | CF AmericaCF America | 3 - 3 | SantosSantos |
| |
| 18 Sep 22 | r15 | CF AmericaCF America | 2 - 1 | CD GuadalajaraCD Guadalajar |
| |
| 01 Oct 22 | r17 | PueblaPuebla | 1 - 2 | CF AmericaCF America |
| |
| 13 Oct 22 | r00 | PueblaPuebla | 1 - 6 | CF AmericaCF America |
| 16 Oct 22 | r00 | CF AmericaCF America | 5 - 1 | PueblaPuebla |
| 20 Oct 22 | r00 | TolucaToluca | 2 - 1 | CF AmericaCF America |
| 23 Oct 22 | r00 | CF AmericaCF America | 1 - 1 | TolucaToluca |
| |
| 07 Jan 23 | r01 | CF AmericaCF America | 0 - 0 | Queretaro FCQueretaro FC |
| |
| 15 Jan 23 | r02 | TolucaToluca | 2 - 2 | CF AmericaCF America |
| |
| 22 Jan 23 | r03 | CF AmericaCF America | 2 - 2 | PueblaPuebla |
| |
| 29 Jan 23 | r04 | CF AmericaCF America | 6 - 0 | MazatlánMazatlán |
| |
| 05 Feb 23 | r05 | SantosSantos | 2 - 2 | CF AmericaCF America |
| |
| 11 Feb 23 | r06 | CF AmericaCF America | 2 - 1 | NecaxaNecaxa |
| |
| 15 Feb 23 | r07 | Atletico de San LuisAtletico de S | 1 - 3 | CF AmericaCF America |
| |
| 20 Feb 23 | r08 | CF AmericaCF America | 2 - 1 | TijuanaTijuana |
| |
| 26 Feb 23 | r09 | AtlasAtlas | 2 - 2 | CF AmericaCF America |
| |
| 05 Mar 23 | r10 | CF AmericaCF America | 0 - 3 | PachucaPachuca |
| |
| 12 Mar 23 | r11 | TigresTigres | 0 - 2 | CF AmericaCF America |
| |
| 19 Mar 23 | r12 | CD GuadalajaraCD Guadalajar | 2 - 4 | CF AmericaCF America |
| |
| 02 Apr 23 | r13 | CF AmericaCF America | 2 - 2 | LeonLeon |
| |
| 09 Apr 23 | r14 | CF AmericaCF America | 2 - 1 | MonterreyMonterrey |
| |
| 16 Apr 23 | r15 | Cruz AzulCruz Azul | 1 - 3 | CF AmericaCF America |
| |
| 23 Apr 23 | r16 | CF AmericaCF America | 1 - 1 | PumasPumas |
| |
| 29 Apr 23 | r17 | FC JuarezFC Juarez | 0 - 1 | CF AmericaCF America |
| |
| 11 May 23 | r00 | Atletico de San LuisAtletico de S | 1 - 3 | CF AmericaCF America |
| 14 May 23 | r00 | CF AmericaCF America | 1 - 2 | Atletico de San LuisAtletico de S |
| 19 May 23 | r00 | CD GuadalajaraCD Guadalajar | 0 - 1 | CF AmericaCF America |
| 22 May 23 | r00 | CF AmericaCF America | 1 - 3 | CD GuadalajaraCD Guadalajar |
Team 2022-2023 Schedules
América
Atlas
Atletico de San Luis
CD Guadalajara
Cruz Azul
Juárez
León
Mazatlán
Monterrey
Necaxa
Pachuca
Puebla
Pumas UNAM
Querétaro
Santos Laguna
Tigres UANL
Tijuana
Toluca
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