| 23 Jul 21 | r01    | Queretaro FCQueretaro FC | 0 - 0 | CF AmericaCF America |
| 24 Jul 21 | r01 | NecaxaNecaxa | 0 - 3 | SantosSantos |
| 24 Jul 21 | r01 | FC JuarezFC Juarez | 1 - 3 | TolucaToluca |
| 24 Jul 21 | r01 | PachucaPachuca | 4 - 0 | LeonLeon |
| 25 Jul 21 | r01 | CD GuadalajaraCD Guadalajar | 1 - 2 | Atletico de San LuisAtletico de S |
| 25 Jul 21 | r01 | PumasPumas | 0 - 0 | AtlasAtlas |
| 26 Jul 21 | r01 | MonterreyMonterrey | 1 - 1 | PueblaPuebla |
| 26 Jul 21 | r01 | TijuanaTijuana | 1 - 2 | TigresTigres |
| 27 Jul 21 | r01 | Cruz AzulCruz Azul | 0 - 2 | MazatlánMazatlán |
| |
| 31 Jul 21 | r02 | MazatlánMazatlán | 2 - 1 | PachucaPachuca |
| 31 Jul 21 | r02 | PueblaPuebla | 0 - 2 | CD GuadalajaraCD Guadalajar |
| 31 Jul 21 | r02 | LeonLeon | 2 - 1 | TijuanaTijuana |
| 01 Aug 21 | r02 | CF AmericaCF America | 2 - 1 | NecaxaNecaxa |
| 01 Aug 21 | r02 | AtlasAtlas | 2 - 0 | FC JuarezFC Juarez |
| 01 Aug 21 | r02 | MonterreyMonterrey | 2 - 0 | PumasPumas |
| 01 Aug 21 | r02 | TolucaToluca | 3 - 1 | TigresTigres |
| 02 Aug 21 | r02 | SantosSantos | 1 - 1 | Cruz AzulCruz Azul |
| 03 Aug 21 | r02 | Atletico de San LuisAtletico de S | 1 - 1 | Queretaro FCQueretaro FC |
| |
| 06 Aug 21 | r03  | Queretaro FCQueretaro FC | 0 - 1 | LeonLeon |
| 07 Aug 21 | r03 | MazatlánMazatlán | 1 - 1 | MonterreyMonterrey |
| 07 Aug 21 | r03 | NecaxaNecaxa | 1 - 2 | Cruz AzulCruz Azul |
| 07 Aug 21 | r03 | TijuanaTijuana | 0 - 2 | TolucaToluca |
| 07 Aug 21 | r03 | CD GuadalajaraCD Guadalajar | 2 - 2 | FC JuarezFC Juarez |
| 08 Aug 21 | r03 | CF AmericaCF America | 2 - 0 | PueblaPuebla |
| 08 Aug 21 | r03 | TigresTigres | 1 - 1 | SantosSantos |
| 08 Aug 21 | r03 | PumasPumas | 1 - 3 | Atletico de San LuisAtletico de S |
| 10 Aug 21 | r03 | PachucaPachuca | 0 - 1 | AtlasAtlas |
| |
| 13 Aug 21 | r04 | Atletico de San LuisAtletico de S | 0 - 2 | NecaxaNecaxa |
| 14 Aug 21 | r04 | PueblaPuebla | 1 - 1 | TigresTigres |
| 14 Aug 21 | r04 | FC JuarezFC Juarez | 1 - 1 | TijuanaTijuana |
| 14 Aug 21 | r04 | PumasPumas | 0 - 0 | Queretaro FCQueretaro FC |
| 15 Aug 21 | r04 | LeonLeon | 3 - 0 | MazatlánMazatlán |
| 15 Aug 21 | r04 | Cruz AzulCruz Azul | 4 - 0 | TolucaToluca |
| 15 Aug 21 | r04 | MonterreyMonterrey | 3 - 1 | PachucaPachuca |
| 15 Aug 21 | r04 | AtlasAtlas | 0 - 1 | CF AmericaCF America |
| 16 Aug 21 | r04 | SantosSantos | 0 - 0 | CD GuadalajaraCD Guadalajar |
| |
| 17 Aug 21 | r05 | TolucaToluca | 2 - 2 | MazatlánMazatlán |
| 18 Aug 21 | r05 | TigresTigres | 3 - 0 | Queretaro FCQueretaro FC |
| 18 Aug 21 | r05 | NecaxaNecaxa | 3 - 0 | PumasPumas |
| 18 Aug 21 | r05 | TijuanaTijuana | 1 - 1 | PueblaPuebla |
| 19 Aug 21 | r05 | Cruz AzulCruz Azul | 1 - 1 | MonterreyMonterrey |
| 19 Aug 21 | r05 | SantosSantos | 1 - 1 | AtlasAtlas |
| 19 Aug 21 | r05 | CD GuadalajaraCD Guadalajar | 0 - 3 | LeonLeon |
| 19 Aug 21 | r05 | FC JuarezFC Juarez | 1 - 2 | CF AmericaCF America |
| |
| 21 Aug 21 | r06 | MazatlánMazatlán | 0 - 3 | TigresTigres |
| 21 Aug 21 | r06 | AtlasAtlas | 0 - 0 | TolucaToluca |
| 22 Aug 21 | r06 | LeonLeon | 1 - 1 | SantosSantos |
| 22 Aug 21 | r06 | Atletico de San LuisAtletico de S | 0 - 0 | Cruz AzulCruz Azul |
| 22 Aug 21 | r06 | MonterreyMonterrey | 0 - 0 | CD GuadalajaraCD Guadalajar |
| 22 Aug 21 | r06 | PumasPumas | 2 - 0 | PueblaPuebla |
| 22 Aug 21 | r06 | CF AmericaCF America | 2 - 0 | TijuanaTijuana |
| 23 Aug 21 | r06 | NecaxaNecaxa | 1 - 0 | FC JuarezFC Juarez |
| 23 Aug 21 | r06 | Queretaro FCQueretaro FC | 0 - 2 | PachucaPachuca |
| |
| 28 Aug 21 | r07 | MazatlánMazatlán | 2 - 2 | Atletico de San LuisAtletico de S |
| 28 Aug 21 | r07 | PueblaPuebla | 1 - 0 | Queretaro FCQueretaro FC |
| 28 Aug 21 | r07 | TijuanaTijuana | 2 - 2 | MonterreyMonterrey |
| 28 Aug 21 | r07 | CD GuadalajaraCD Guadalajar | 2 - 1 | NecaxaNecaxa |
| 29 Aug 21 | r07 | TigresTigres | 1 - 1 | AtlasAtlas |
| 29 Aug 21 | r07 | LeonLeon | 1 - 1 | CF AmericaCF America |
| 29 Aug 21 | r07 | TolucaToluca | 2 - 1 | PumasPumas |
| 30 Aug 21 | r07 | SantosSantos | 2 - 0 | FC JuarezFC Juarez |
| 30 Aug 21 | r07 | Cruz AzulCruz Azul | 1 - 1 | PachucaPachuca |
| |
| 11 Sep 21 | r08 | PueblaPuebla | 2 - 2 | Atletico de San LuisAtletico de S |
| 11 Sep 21 | r08 | FC JuarezFC Juarez | 2 - 1 | Cruz AzulCruz Azul |
| 11 Sep 21 | r08 | TijuanaTijuana | 2 - 1 | SantosSantos |
| 11 Sep 21 | r08 | AtlasAtlas | 2 - 1 | MonterreyMonterrey |
| 12 Sep 21 | r08 | TigresTigres | 2 - 2 | LeonLeon |
| 12 Sep 21 | r08 | CF AmericaCF America | 2 - 0 | MazatlánMazatlán |
| 12 Sep 21 | r08 | PumasPumas | 0 - 0 | CD GuadalajaraCD Guadalajar |
| 13 Sep 21 | r08 | Queretaro FCQueretaro FC | 3 - 0 | NecaxaNecaxa |
| 14 Sep 21 | r08 | PachucaPachuca | 1 - 2 | TolucaToluca |
| |
| 17 Sep 21 | r09 | Atletico de San LuisAtletico de S | 4 - 1 | TijuanaTijuana |
| 18 Sep 21 | r09 | NecaxaNecaxa | 0 - 3 | AtlasAtlas |
| 18 Sep 21 | r09 | LeonLeon | 0 - 1 | FC JuarezFC Juarez |
| 19 Sep 21 | r09 | TolucaToluca | 3 - 1 | CF AmericaCF America |
| 19 Sep 21 | r09 | MazatlánMazatlán | 2 - 2 | PumasPumas |
| 19 Sep 21 | r09 | CD GuadalajaraCD Guadalajar | 1 - 0 | PachucaPachuca |
| 20 Sep 21 | r09 | Cruz AzulCruz Azul | 2 - 0 | Queretaro FCQueretaro FC |
| 20 Sep 21 | r09 | MonterreyMonterrey | 2 - 0 | TigresTigres |
| 20 Sep 21 | r09 | SantosSantos | 1 - 1 | PueblaPuebla |
| |
| 22 Sep 21 | r14 | FC JuarezFC Juarez | 1 - 0 | Atletico de San LuisAtletico de S |
| |
| 23 Sep 21 | r11 | MonterreyMonterrey | 2 - 0 | TolucaToluca |
| |
| 24 Sep 21 | r10 | PachucaPachuca | 1 - 0 | NecaxaNecaxa |
| 25 Sep 21 | r10 | PueblaPuebla | 1 - 1 | Cruz AzulCruz Azul |
| 25 Sep 21 | r10 | TijuanaTijuana | 0 - 0 | MazatlánMazatlán |
| 25 Sep 21 | r10 | AtlasAtlas | 2 - 0 | LeonLeon |
| 26 Sep 21 | r10 | TigresTigres | 0 - 0 | PumasPumas |
| 26 Sep 21 | r10 | CF AmericaCF America | 0 - 0 | CD GuadalajaraCD Guadalajar |
| 26 Sep 21 | r10 | TolucaToluca | 1 - 2 | Atletico de San LuisAtletico de S |
| 27 Sep 21 | r10 | SantosSantos | 1 - 2 | MonterreyMonterrey |
| |
| 28 Sep 21 | r11 | NecaxaNecaxa | 3 - 0 | TijuanaTijuana |
| 29 Sep 21 | r11 | MazatlánMazatlán | 3 - 1 | FC JuarezFC Juarez |
| 29 Sep 21 | r11 | AtlasAtlas | 0 - 1 | PueblaPuebla |
| 29 Sep 21 | r11 | PachucaPachuca | 1 - 1 | CF AmericaCF America |
| 29 Sep 21 | r11 | Atletico de San LuisAtletico de S | 0 - 3 | TigresTigres |
| 30 Sep 21 | r11 | Queretaro FCQueretaro FC | 1 - 0 | CD GuadalajaraCD Guadalajar |
| |
| 02 Oct 21 | r12 | PueblaPuebla | 1 - 2 | PachucaPachuca |
| 02 Oct 21 | r12 | FC JuarezFC Juarez | 3 - 1 | MonterreyMonterrey |
| 02 Oct 21 | r12 | LeonLeon | 0 - 0 | Atletico de San LuisAtletico de S |
| 03 Oct 21 | r12 | SantosSantos | 1 - 0 | MazatlánMazatlán |
| 03 Oct 21 | r12 | CD GuadalajaraCD Guadalajar | 0 - 1 | AtlasAtlas |
| 03 Oct 21 | r12 | TolucaToluca | 1 - 1 | Queretaro FCQueretaro FC |
| 03 Oct 21 | r12 | CF AmericaCF America | 2 - 0 | PumasPumas |
| 04 Oct 21 | r12 | TigresTigres | 0 - 0 | NecaxaNecaxa |
| 04 Oct 21 | r12 | TijuanaTijuana | 0 - 1 | Cruz AzulCruz Azul |
| |
| 09 Oct 21 | r10 | FC JuarezFC Juarez | 0 - 0 | Queretaro FCQueretaro FC |
| |
| 15 Oct 21 | r13 | Queretaro FCQueretaro FC | 1 - 1 | TijuanaTijuana |
| 16 Oct 21 | r13 | NecaxaNecaxa | 0 - 1 | PueblaPuebla |
| 16 Oct 21 | r13 | MazatlánMazatlán | 1 - 0 | AtlasAtlas |
| 16 Oct 21 | r13 | MonterreyMonterrey | 0 - 1 | LeonLeon |
| 17 Oct 21 | r13 | Atletico de San LuisAtletico de S | 0 - 1 | CF AmericaCF America |
| 17 Oct 21 | r13 | PachucaPachuca | 1 - 1 | SantosSantos |
| 17 Oct 21 | r13 | Cruz AzulCruz Azul | 1 - 1 | TigresTigres |
| 17 Oct 21 | r13 | PumasPumas | 1 - 0 | FC JuarezFC Juarez |
| 17 Oct 21 | r13 | CD GuadalajaraCD Guadalajar | 2 - 0 | TolucaToluca |
| |
| 19 Oct 21 | r14 | Queretaro FCQueretaro FC | 1 - 0 | MonterreyMonterrey |
| 20 Oct 21 | r14 | PueblaPuebla | 2 - 0 | MazatlánMazatlán |
| 20 Oct 21 | r14 | CF AmericaCF America | 2 - 1 | SantosSantos |
| 20 Oct 21 | r14 | AtlasAtlas | 0 - 0 | Cruz AzulCruz Azul |
| 21 Oct 21 | r14 | TolucaToluca | 1 - 1 | NecaxaNecaxa |
| 21 Oct 21 | r14 | LeonLeon | 1 - 2 | PumasPumas |
| 21 Oct 21 | r14 | TigresTigres | 3 - 0 | PachucaPachuca |
| 21 Oct 21 | r14 | TijuanaTijuana | 0 - 0 | CD GuadalajaraCD Guadalajar |
| |
| 23 Oct 21 | r15 | MazatlánMazatlán | 2 - 1 | Queretaro FCQueretaro FC |
| 23 Oct 21 | r15 | PueblaPuebla | 0 - 1 | LeonLeon |
| 24 Oct 21 | r15 | CF AmericaCF America | 1 - 0 | TigresTigres |
| 24 Oct 21 | r15 | CD GuadalajaraCD Guadalajar | 1 - 1 | Cruz AzulCruz Azul |
| 24 Oct 21 | r15 | PumasPumas | 3 - 1 | TijuanaTijuana |
| 24 Oct 21 | r15 | MonterreyMonterrey | 0 - 1 | NecaxaNecaxa |
| 25 Oct 21 | r15 | Atletico de San LuisAtletico de S | 2 - 6 | AtlasAtlas |
| 25 Oct 21 | r15 | SantosSantos | 2 - 2 | TolucaToluca |
| 25 Oct 21 | r15 | PachucaPachuca | 1 - 1 | FC JuarezFC Juarez |
| |
| 29 Oct 21 | r16 | AtlasAtlas | 0 - 2 | TijuanaTijuana |
| 30 Oct 21 | r16 | NecaxaNecaxa | 2 - 1 | MazatlánMazatlán |
| 30 Oct 21 | r16 | FC JuarezFC Juarez | 0 - 2 | PueblaPuebla |
| 31 Oct 21 | r16 | Queretaro FCQueretaro FC | 2 - 3 | SantosSantos |
| 31 Oct 21 | r16 | PachucaPachuca | 1 - 1 | PumasPumas |
| 31 Oct 21 | r16 | TigresTigres | 2 - 1 | CD GuadalajaraCD Guadalajar |
| 31 Oct 21 | r16 | TolucaToluca | 0 - 0 | LeonLeon |
| 31 Oct 21 | r16 | Cruz AzulCruz Azul | 2 - 1 | CF AmericaCF America |
| 01 Nov 21 | r16 | Atletico de San LuisAtletico de S | 1 - 1 | MonterreyMonterrey |
| |
| 04 Nov 21 | r05 | PachucaPachuca | 0 - 0 | Atletico de San LuisAtletico de S |
| |
| 04 Nov 21 | r11 | Cruz AzulCruz Azul | 0 - 1 | LeonLeon |
| 05 Nov 21 | r11 | PumasPumas | 0 - 3 | SantosSantos |
| |
| 05 Nov 21 | r17 | AtlasAtlas | 2 - 0 | Queretaro FCQueretaro FC |
| 06 Nov 21 | r17 | PueblaPuebla | 1 - 0 | TolucaToluca |
| 06 Nov 21 | r17 | MazatlánMazatlán | 0 - 1 | CD GuadalajaraCD Guadalajar |
| 06 Nov 21 | r17 | LeonLeon | 3 - 0 | NecaxaNecaxa |
| 07 Nov 21 | r17 | CF AmericaCF America | 0 - 0 | MonterreyMonterrey |
| 07 Nov 21 | r17 | TigresTigres | 3 - 0 | FC JuarezFC Juarez |
| 07 Nov 21 | r17 | TijuanaTijuana | 3 - 2 | PachucaPachuca |
| 07 Nov 21 | r17 | PumasPumas | 4 - 3 | Cruz AzulCruz Azul |
| 08 Nov 21 | r17 | SantosSantos | 0 - 0 | Atletico de San LuisAtletico de S |
| |
| 21 Nov 21 | r00  | SantosSantos | 2 - 0 | Atletico de San LuisAtletico de S |
| 21 Nov 21 | r00 | PueblaPuebla | 2 - 2 | CD GuadalajaraCD Guadalajar |
| 21 Nov 21 | r00 | TolucaToluca | 1 - 2 | PumasPumas |
| 22 Nov 21 | r00 | Cruz AzulCruz Azul | 1 - 4 | MonterreyMonterrey |
| 25 Nov 21 | r00 | PumasPumas | 0 - 0 | CF AmericaCF America |
| 25 Nov 21 | r00 | MonterreyMonterrey | 0 - 0 | AtlasAtlas |
| 26 Nov 21 | r00 | PueblaPuebla | 2 - 1 | LeonLeon |
| 26 Nov 21 | r00 | SantosSantos | 2 - 1 | TigresTigres |
| 28 Nov 21 | r00 | CF AmericaCF America | 1 - 3 | PumasPumas |
| 28 Nov 21 | r00 | AtlasAtlas | 1 - 1 | MonterreyMonterrey |
| 29 Nov 21 | r00 | TigresTigres | 1 - 0 | SantosSantos |
| 29 Nov 21 | r00 | LeonLeon | 2 - 0 | PueblaPuebla |
| 02 Dec 21 | r00 | TigresTigres | 2 - 1 | LeonLeon |
| 03 Dec 21 | r00 | PumasPumas | 0 - 1 | AtlasAtlas |
| 05 Dec 21 | r00 | LeonLeon | 2 - 1 | TigresTigres |
| 06 Dec 21 | r00 | AtlasAtlas | 0 - 1 | PumasPumas |
| 10 Dec 21 | r00 | LeonLeon | 3 - 2 | AtlasAtlas |
| 13 Dec 21 | r00 | AtlasAtlas | 1 - 0 | LeonLeon |
| |
| 07 Jan 22 | r01 | Atletico de San LuisAtletico de S | 0 - 2 | PachucaPachuca |
| 08 Jan 22 | r01 | FC JuarezFC Juarez | 2 - 1 | NecaxaNecaxa |
| 08 Jan 22 | r01 | PueblaPuebla | 1 - 1 | CF AmericaCF America |
| 09 Jan 22 | r01 | MonterreyMonterrey | 0 - 0 | Queretaro FCQueretaro FC |
| 09 Jan 22 | r01 | Cruz AzulCruz Azul | 2 - 0 | TijuanaTijuana |
| 10 Jan 22 | r01 | CD GuadalajaraCD Guadalajar | 3 - 0 | MazatlánMazatlán |
| 11 Jan 22 | r01 | PumasPumas | 5 - 0 | TolucaToluca |
| 13 Jan 22 | r01 | SantosSantos | 1 - 1 | TigresTigres |
| |
| 15 Jan 22 | r02 | Queretaro FCQueretaro FC | 1 - 3 | PumasPumas |
| 15 Jan 22 | r02 | NecaxaNecaxa | 0 - 4 | MonterreyMonterrey |
| 15 Jan 22 | r02 | AtlasAtlas | 1 - 0 | Atletico de San LuisAtletico de S |
| 16 Jan 22 | r02 | TigresTigres | 0 - 2 | PueblaPuebla |
| 16 Jan 22 | r02 | Cruz AzulCruz Azul | 1 - 0 | FC JuarezFC Juarez |
| 16 Jan 22 | r02 | TijuanaTijuana | 1 - 1 | LeonLeon |
| 16 Jan 22 | r02 | TolucaToluca | 3 - 1 | SantosSantos |
| 16 Jan 22 | r02 | PachucaPachuca | 2 - 1 | CD GuadalajaraCD Guadalajar |
| |
| 20 Jan 22 | r01 | LeonLeon | 1 - 1 | AtlasAtlas |
| |
| 21 Jan 22 | r03 | Atletico de San LuisAtletico de S | 0 - 1 | FC JuarezFC Juarez |
| 22 Jan 22 | r03 | MazatlánMazatlán | 1 - 2 | TolucaToluca |
| 22 Jan 22 | r03 | CD GuadalajaraCD Guadalajar | 1 - 1 | Queretaro FCQueretaro FC |
| 23 Jan 22 | r03 | LeonLeon | 2 - 1 | PachucaPachuca |
| 23 Jan 22 | r03 | CF AmericaCF America | 0 - 2 | AtlasAtlas |
| 23 Jan 22 | r03 | MonterreyMonterrey | 2 - 2 | Cruz AzulCruz Azul |
| 23 Jan 22 | r03 | PumasPumas | 1 - 2 | TigresTigres |
| 24 Jan 22 | r03 | SantosSantos | 1 - 4 | NecaxaNecaxa |
| 29 Jan 22 | r03 | PueblaPuebla | 3 - 1 | TijuanaTijuana |
| |
| 05 Feb 22 | r04 | NecaxaNecaxa | 1 - 3 | PachucaPachuca |
| 06 Feb 22 | r04 | CF AmericaCF America | 2 - 3 | Atletico de San LuisAtletico de S |
| 06 Feb 22 | r04 | TijuanaTijuana | 1 - 0 | PumasPumas |
| 06 Feb 22 | r04 | Queretaro FCQueretaro FC | 0 - 2 | PueblaPuebla |
| 07 Feb 22 | r04 | AtlasAtlas | 2 - 1 | SantosSantos |
| 07 Feb 22 | r04 | TigresTigres | 4 - 3 | MazatlánMazatlán |
| 08 Feb 22 | r04 | LeonLeon | 0 - 1 | Cruz AzulCruz Azul |
| 10 Feb 22 | r04 | FC JuarezFC Juarez | 1 - 3 | CD GuadalajaraCD Guadalajar |
| |
| 12 Feb 22 | r05 | MazatlánMazatlán | 2 - 0 | TijuanaTijuana |
| 12 Feb 22 | r05 | PueblaPuebla | 1 - 1 | AtlasAtlas |
| 12 Feb 22 | r05 | Atletico de San LuisAtletico de S | 0 - 1 | TolucaToluca |
| 12 Feb 22 | r05 | CD GuadalajaraCD Guadalajar | 1 - 3 | TigresTigres |
| 13 Feb 22 | r05 | Cruz AzulCruz Azul | 1 - 2 | NecaxaNecaxa |
| 13 Feb 22 | r05 | SantosSantos | 2 - 3 | CF AmericaCF America |
| 13 Feb 22 | r05 | PumasPumas | 2 - 1 | LeonLeon |
| 15 Feb 22 | r05 | PachucaPachuca | 2 - 2 | Queretaro FCQueretaro FC |
| |
| 17 Feb 22 | r02 | MazatlánMazatlán | 2 - 1 | CF AmericaCF America |
| |
| 19 Feb 22 | r06 | PueblaPuebla | 1 - 0 | MonterreyMonterrey |
| 19 Feb 22 | r06 | FC JuarezFC Juarez | 0 - 0 | SantosSantos |
| 19 Feb 22 | r06 | TijuanaTijuana | 1 - 1 | NecaxaNecaxa |
| 19 Feb 22 | r06 | Queretaro FCQueretaro FC | 2 - 0 | MazatlánMazatlán |
| 20 Feb 22 | r06 | TigresTigres | 2 - 1 | Atletico de San LuisAtletico de S |
| 20 Feb 22 | r06 | LeonLeon | 2 - 1 | CD GuadalajaraCD Guadalajar |
| 20 Feb 22 | r06 | CF AmericaCF America | 1 - 3 | PachucaPachuca |
| 21 Feb 22 | r06 | TolucaToluca | 1 - 4 | Cruz AzulCruz Azul |
| 21 Feb 22 | r06 | AtlasAtlas | 0 - 0 | PumasPumas |
| |
| 25 Feb 22 | r07 | PachucaPachuca | 3 - 1 | MazatlánMazatlán |
| 25 Feb 22 | r07 | Queretaro FCQueretaro FC | 1 - 1 | TolucaToluca |
| 26 Feb 22 | r07 | NecaxaNecaxa | 0 - 1 | LeonLeon |
| 26 Feb 22 | r07 | FC JuarezFC Juarez | 2 - 3 | TigresTigres |
| 26 Feb 22 | r07 | TijuanaTijuana | 2 - 0 | AtlasAtlas |
| 27 Feb 22 | r07 | CD GuadalajaraCD Guadalajar | 2 - 3 | PueblaPuebla |
| 27 Feb 22 | r07 | PumasPumas | 0 - 0 | CF AmericaCF America |
| 27 Feb 22 | r07 | MonterreyMonterrey | 0 - 2 | Atletico de San LuisAtletico de S |
| 28 Feb 22 | r07 | Cruz AzulCruz Azul | 1 - 2 | SantosSantos |
| |
| 02 Mar 22 | r08 | TolucaToluca | 1 - 2 | TijuanaTijuana |
| 02 Mar 22 | r08 | PueblaPuebla | 1 - 1 | FC JuarezFC Juarez |
| 02 Mar 22 | r08 | LeonLeon | 0 - 0 | MonterreyMonterrey |
| 02 Mar 22 | r08 | MazatlánMazatlán | 0 - 0 | NecaxaNecaxa |
| 02 Mar 22 | r08 | CF AmericaCF America | 1 - 1 | Queretaro FCQueretaro FC |
| 03 Mar 22 | r08 | AtlasAtlas | 0 - 1 | PachucaPachuca |
| 03 Mar 22 | r08 | TigresTigres | 2 - 2 | Cruz AzulCruz Azul |
| 03 Mar 22 | r08 | Atletico de San LuisAtletico de S | 2 - 2 | CD GuadalajaraCD Guadalajar |
| 03 Mar 22 | r08 | SantosSantos | 3 - 2 | PumasPumas |
| |
| 05 Mar 22 | r09 | NecaxaNecaxa | 0 - 1 | TolucaToluca |
| 05 Mar 22 | r09 | FC JuarezFC Juarez | 0 - 1 | LeonLeon |
| 05 Mar 22 | r09 | Queretaro FCQueretaro FC | 0 - 1 | AtlasAtlas |
| 06 Mar 22 | r09 | MonterreyMonterrey | 2 - 1 | CF AmericaCF America |
| 06 Mar 22 | r09 | Cruz AzulCruz Azul | 1 - 3 | PueblaPuebla |
| 06 Mar 22 | r09 | CD GuadalajaraCD Guadalajar | 1 - 0 | SantosSantos |
| |
| 12 Mar 22 | r10 | NecaxaNecaxa | 1 - 0 | Queretaro FCQueretaro FC |
| 12 Mar 22 | r10 | FC JuarezFC Juarez | 1 - 2 | AtlasAtlas |
| 12 Mar 22 | r10 | MonterreyMonterrey | 2 - 1 | MazatlánMazatlán |
| 12 Mar 22 | r10 | LeonLeon | 0 - 3 | TigresTigres |
| 13 Mar 22 | r10 | Cruz AzulCruz Azul | 2 - 1 | PumasPumas |
| 13 Mar 22 | r10 | CD GuadalajaraCD Guadalajar | 0 - 0 | CF AmericaCF America |
| 13 Mar 22 | r10 | TolucaToluca | 0 - 3 | PachucaPachuca |
| 13 Mar 22 | r10 | Atletico de San LuisAtletico de S | 2 - 1 | PueblaPuebla |
| 14 Mar 22 | r10 | SantosSantos | 4 - 0 | TijuanaTijuana |
| |
| 16 Mar 22 | r05 | MonterreyMonterrey | 3 - 0 | FC JuarezFC Juarez |
| |
| 18 Mar 22 | r11 | Queretaro FCQueretaro FC | 2 - 1 | Atletico de San LuisAtletico de S |
| 19 Mar 22 | r11 | PueblaPuebla | 2 - 2 | SantosSantos |
| 19 Mar 22 | r11 | PumasPumas | 1 - 3 | NecaxaNecaxa |
| 20 Mar 22 | r11 | TigresTigres | 2 - 0 | MonterreyMonterrey |
| 20 Mar 22 | r11 | PachucaPachuca | 1 - 0 | Cruz AzulCruz Azul |
| 20 Mar 22 | r11 | CF AmericaCF America | 3 - 0 | TolucaToluca |
| 21 Mar 22 | r11 | AtlasAtlas | 1 - 1 | CD GuadalajaraCD Guadalajar |
| 21 Mar 22 | r11 | MazatlánMazatlán | 1 - 2 | LeonLeon |
| 21 Mar 22 | r11 | TijuanaTijuana | 1 - 0 | FC JuarezFC Juarez |
| |
| 27 Mar 22 | r09 | PumasPumas | 1 - 1 | MazatlánMazatlán |
| |
| 02 Apr 22 | r12 | Atletico de San LuisAtletico de S | 1 - 0 | MazatlánMazatlán |
| 03 Apr 22 | r12 | NecaxaNecaxa | 0 - 1 | CF AmericaCF America |
| 03 Apr 22 | r12 | FC JuarezFC Juarez | 0 - 1 | PumasPumas |
| 03 Apr 22 | r12 | TolucaToluca | 2 - 1 | PueblaPuebla |
| 03 Apr 22 | r12 | LeonLeon | 1 - 1 | Queretaro FCQueretaro FC |
| 04 Apr 22 | r12 | Cruz AzulCruz Azul | 1 - 0 | AtlasAtlas |
| 04 Apr 22 | r12 | TigresTigres | 2 - 0 | TijuanaTijuana |
| 04 Apr 22 | r12 | SantosSantos | 3 - 1 | PachucaPachuca |
| |
| 07 Apr 22 | r04 | TolucaToluca | 2 - 2 | MonterreyMonterrey |
| |
| 07 Apr 22 | r09 | TijuanaTijuana | 1 - 1 | Atletico de San LuisAtletico de S |
| 08 Apr 22 | r09 | PachucaPachuca | 2 - 1 | TigresTigres |
| |
| 08 Apr 22 | r13 | AtlasAtlas | 2 - 1 | NecaxaNecaxa |
| 09 Apr 22 | r13 | PueblaPuebla | 2 - 2 | PumasPumas |
| 09 Apr 22 | r13 | MazatlánMazatlán | 1 - 1 | Cruz AzulCruz Azul |
| 09 Apr 22 | r13 | Atletico de San LuisAtletico de S | 2 - 0 | LeonLeon |
| 10 Apr 22 | r13 | TolucaToluca | 1 - 1 | CD GuadalajaraCD Guadalajar |
| 10 Apr 22 | r13 | MonterreyMonterrey | 1 - 0 | SantosSantos |
| 10 Apr 22 | r13 | CF AmericaCF America | 3 - 0 | FC JuarezFC Juarez |
| 11 Apr 22 | r13 | Queretaro FCQueretaro FC | 0 - 1 | TigresTigres |
| 12 Apr 22 | r13 | PachucaPachuca | 0 - 0 | TijuanaTijuana |
| |
| 14 Apr 22 | r12 | CD GuadalajaraCD Guadalajar | 1 - 3 | MonterreyMonterrey |
| |
| 15 Apr 22 | r14 | AtlasAtlas | 1 - 2 | MazatlánMazatlán |
| 16 Apr 22 | r14 | NecaxaNecaxa | 4 - 2 | Atletico de San LuisAtletico de S |
| 16 Apr 22 | r14 | FC JuarezFC Juarez | 1 - 2 | PachucaPachuca |
| 16 Apr 22 | r14 | TijuanaTijuana | 1 - 3 | CF AmericaCF America |
| 16 Apr 22 | r14 | LeonLeon | 0 - 1 | PueblaPuebla |
| 17 Apr 22 | r14 | SantosSantos | 1 - 1 | Queretaro FCQueretaro FC |
| 17 Apr 22 | r14 | TigresTigres | 3 - 0 | TolucaToluca |
| 17 Apr 22 | r14 | Cruz AzulCruz Azul | 0 - 1 | CD GuadalajaraCD Guadalajar |
| 17 Apr 22 | r14 | PumasPumas | 2 - 0 | MonterreyMonterrey |
| |
| 20 Apr 22 | r15 | PachucaPachuca | 1 - 0 | PueblaPuebla |
| 20 Apr 22 | r15 | NecaxaNecaxa | 2 - 0 | TigresTigres |
| 20 Apr 22 | r15 | MazatlánMazatlán | 1 - 0 | SantosSantos |
| 20 Apr 22 | r15 | TolucaToluca | 0 - 1 | FC JuarezFC Juarez |
| 20 Apr 22 | r15 | CD GuadalajaraCD Guadalajar | 2 - 1 | TijuanaTijuana |
| 21 Apr 22 | r15 | Atletico de San LuisAtletico de S | 2 - 0 | PumasPumas |
| 21 Apr 22 | r15 | CF AmericaCF America | 2 - 0 | LeonLeon |
| 21 Apr 22 | r15 | MonterreyMonterrey | 0 - 0 | AtlasAtlas |
| 22 Apr 22 | r15 | Queretaro FCQueretaro FC | 0 - 1 | Cruz AzulCruz Azul |
| |
| 23 Apr 22 | r16 | PueblaPuebla | 0 - 1 | NecaxaNecaxa |
| 23 Apr 22 | r16 | FC JuarezFC Juarez | 0 - 2 | MazatlánMazatlán |
| 23 Apr 22 | r16 | PachucaPachuca | 3 - 0 | MonterreyMonterrey |
| 24 Apr 22 | r16 | TigresTigres | 0 - 2 | CF AmericaCF America |
| 24 Apr 22 | r16 | CD GuadalajaraCD Guadalajar | 3 - 1 | PumasPumas |
| 24 Apr 22 | r16 | TolucaToluca | 2 - 4 | AtlasAtlas |
| 24 Apr 22 | r16 | Cruz AzulCruz Azul | 0 - 1 | Atletico de San LuisAtletico de S |
| 25 Apr 22 | r16 | SantosSantos | 1 - 1 | LeonLeon |
| 25 Apr 22 | r16 | TijuanaTijuana | 2 - 2 | Queretaro FCQueretaro FC |
| |
| 30 Apr 22 | r17 | NecaxaNecaxa | 0 - 1 | CD GuadalajaraCD Guadalajar |
| 30 Apr 22 | r17 | MazatlánMazatlán | 2 - 1 | PueblaPuebla |
| 30 Apr 22 | r17 | Queretaro FCQueretaro FC | 4 - 0 | FC JuarezFC Juarez |
| 01 May 22 | r17 | AtlasAtlas | 1 - 1 | TigresTigres |
| 01 May 22 | r17 | MonterreyMonterrey | 2 - 0 | TijuanaTijuana |
| 01 May 22 | r17 | CF AmericaCF America | 0 - 0 | Cruz AzulCruz Azul |
| 01 May 22 | r17 | PumasPumas | 2 - 0 | PachucaPachuca |
| 01 May 22 | r17 | Atletico de San LuisAtletico de S | 1 - 3 | SantosSantos |
| 02 May 22 | r17 | LeonLeon | 4 - 4 | TolucaToluca |
| |
| 07 May 22 | Qualifier | Cruz AzulCruz Azul | 1 - 1 | NecaxaNecaxa |
| 08 May 22 | Qualifier | MonterreyMonterrey | 2 - 2 | Atletico de San LuisAtletico de S |
| 08 May 22 | Qualifier | PueblaPuebla | 2 - 2 | MazatlánMazatlán |
| 09 May 22 | Qualifier | CD GuadalajaraCD Guadalajar | 4 - 1 | PumasPumas |
| |
| 12 May 22 | Playoff | Atletico de San LuisAtletico de S | 2 - 2 | PachucaPachuca |
| 12 May 22 | Playoff | PueblaPuebla | 1 - 1 | CF AmericaCF America |
| 13 May 22 | Playoff | Cruz AzulCruz Azul | 0 - 1 | TigresTigres |
| 13 May 22 | Playoff | CD GuadalajaraCD Guadalajar | 1 - 2 | AtlasAtlas |
| 15 May 22 | Playoff | CF AmericaCF America | 3 - 2 | PueblaPuebla |
| 15 May 22 | Playoff | PachucaPachuca | 3 - 2 | Atletico de San LuisAtletico de S |
| 15 May 22 | Playoff | AtlasAtlas | 1 - 1 | CD GuadalajaraCD Guadalajar |
| 16 May 22 | Playoff | TigresTigres | 0 - 1 | Cruz AzulCruz Azul |
| |
| 19 May 22 | SF | AtlasAtlas | 3 - 0 | TigresTigres |
| 20 May 22 | SF | CF AmericaCF America | 1 - 1 | PachucaPachuca |
| 22 May 22 | SF | TigresTigres | 4 - 2 | AtlasAtlas |
| 23 May 22 | SF | PachucaPachuca | 3 - 0 | CF AmericaCF America |
| |
| 27 May 22 | Final | AtlasAtlas | 2 - 0 | PachucaPachuca |
| 30 May 22 | Final | PachucaPachuca | 2 - 1 | AtlasAtlas |
Team 2021-2022 Schedules
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