

Team 2022 Scheduals| 26 Feb |
r01 | Los Angeles FCLos Angeles F | 3 - 0 | Colorado RapidsColorado Rapi |
| 05 Mar |
r03 | Colorado RapidsColorado Rapi | 3 - 0 | Atlanta UnitedAtlanta Unite |
| 13 Mar |
r04 | Colorado RapidsColorado Rapi | 2 - 0 | Sporting Kansas CitySporting Kans |
| 20 Mar |
r06 | Houston DynamoHouston Dynam | 1 - 1 | Colorado RapidsColorado Rapi |
| 03 Apr |
r08 | Colorado RapidsColorado Rapi | 1 - 1 | Real Salt LakeReal Salt Lak |
| 10 Apr |
r09 | FC DallasFC Dallas | 3 - 1 | Colorado RapidsColorado Rapi |
| 17 Apr |
r10 | Minnesota UnitedMinnesota Uni | 3 - 1 | Colorado RapidsColorado Rapi |
| 24 Apr |
r11 ![]() | Colorado RapidsColorado Rapi | 0 - 0 | Charlotte FCCharlotte FC |
| 01 May |
r13 | Colorado RapidsColorado Rapi | 2 - 0 | Portland TimbersPortland Timb |
| 08 May |
r13 | San Jose EarthquakesSan Jose Eart | 1 - 0 | Colorado RapidsColorado Rapi |
| 14 May |
r15 | Colorado RapidsColorado Rapi | 2 - 0 | Los Angeles FCLos Angeles F |
| 19 May |
r17 | Sporting Kansas CitySporting Kans | 2 - 1 | Colorado RapidsColorado Rapi |
| 23 May |
r18 | Colorado RapidsColorado Rapi | 1 - 0 | Seattle Sounders FCSeattle Sound |
| 29 May |
r20 | Colorado RapidsColorado Rapi | 1 - 3 | Nashville SCNashville SC |
| 19 Jun |
r22 | New York CityNew York City | 1 - 1 | Colorado RapidsColorado Rapi |
| 26 Jun |
r23 | Portland TimbersPortland Timb | 3 - 0 | Colorado RapidsColorado Rapi |
| 05 Jul |
r25 | Colorado RapidsColorado Rapi | 2 - 3 | Austin FCAustin FC |
| 10 Jul |
r27 | Real Salt LakeReal Salt Lak | 2 - 2 | Colorado RapidsColorado Rapi |
| 14 Jul |
r28 | Colorado RapidsColorado Rapi | 1 - 1 | Orlando CityOrlando City |
| 17 Jul |
r29 | Colorado RapidsColorado Rapi | 2 - 0 | L.A. GalaxyL.A. Galaxy |
| 24 Jul |
r30 | Seattle Sounders FCSeattle Sound | 2 - 1 | Colorado RapidsColorado Rapi |
| 02 Aug |
r31 | New York Red BullsNew York Red | 4 - 5 | Colorado RapidsColorado Rapi |
| 07 Aug |
r34 | Colorado RapidsColorado Rapi | 4 - 3 | Minnesota UnitedMinnesota Uni |
| 14 Aug |
r35 | Colorado RapidsColorado Rapi | 1 - 1 | Columbus CrewColumbus Crew |
| 18 Aug |
r36 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Colorado RapidsColorado Rapi |
| 21 Aug |
r37 | Colorado RapidsColorado Rapi | 1 - 1 | Houston DynamoHouston Dynam |
| 27 Aug |
r38 | Philadelphia UnionPhiladelphia | 6 - 0 | Colorado RapidsColorado Rapi |
| 01 Sep |
r40 | Nashville SCNashville SC | 4 - 1 | Colorado RapidsColorado Rapi |
| 04 Sep |
r41 | DC UnitedDC United | 0 - 0 | Colorado RapidsColorado Rapi |
| 11 Sep |
r43 | Colorado RapidsColorado Rapi | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| 15 Sep |
r44 | Colorado RapidsColorado Rapi | 2 - 1 | San Jose EarthquakesSan Jose Eart |
| 18 Sep |
r45 | L.A. GalaxyL.A. Galaxy | 4 - 1 | Colorado RapidsColorado Rapi |
| 01 Oct |
r46 | Colorado RapidsColorado Rapi | 1 - 0 | FC DallasFC Dallas |
| 09 Oct |
r47 | Austin FCAustin FC | 1 - 1 | Colorado RapidsColorado Rapi |