| 27 Feb 22 | r01        | Portland TimbersPortland Timb | 2 - 2 | New England Rev.New England R |
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| 07 Mar 22 | r03        | Los Angeles FCLos Angeles F | 1 - 1 | Portland TimbersPortland Timb |
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| 13 Mar 22 | r04        | Portland TimbersPortland Timb | 1 - 0 | Austin FCAustin FC |
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| 20 Mar 22 | r06        | FC DallasFC Dallas | 4 - 1 | Portland TimbersPortland Timb |
| 27 Mar 22 | r06        | Portland TimbersPortland Timb | 1 - 1 | Orlando CityOrlando City |
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| 03 Apr 22 | r08        | Portland TimbersPortland Timb | 1 - 3 | L.A. GalaxyL.A. Galaxy |
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| 10 Apr 22 | r09        | Vancouver WhitecapsVancouver Whi | 2 - 3 | Portland TimbersPortland Timb |
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| 16 Apr 22 | r10        | Houston DynamoHouston Dynam | 0 - 0 | Portland TimbersPortland Timb |
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| 24 Apr 22 | r11        | Portland TimbersPortland Timb | 0 - 0 | Real Salt LakeReal Salt Lak |
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| 01 May 22 | r13        | Colorado RapidsColorado Rapi | 2 - 0 | Portland TimbersPortland Timb |
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| 07 May 22 | r14        | New York Red BullsNew York Red | 1 - 1 | Portland TimbersPortland Timb |
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| 15 May 22 | r16        | Portland TimbersPortland Timb | 7 - 2 | Sporting Kansas CitySporting Kans |
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| 19 May 22 | r17        | San Jose EarthquakesSan Jose Eart | 3 - 2 | Portland TimbersPortland Timb |
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| 23 May 22 | r19        | Portland TimbersPortland Timb | 0 - 2 | Philadelphia UnionPhiladelphia |
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| 29 May 22 | r20        | Inter MiamiInter Miami | 2 - 1 | Portland TimbersPortland Timb |
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| 18 Jun 22 | r21        | L.A. GalaxyL.A. Galaxy | 1 - 1 | Portland TimbersPortland Timb |
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| 26 Jun 22 | r23        | Portland TimbersPortland Timb | 3 - 0 | Colorado RapidsColorado Rapi |
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| 30 Jun 22 | r24        | Portland TimbersPortland Timb | 2 - 1 | Houston DynamoHouston Dynam |
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| 04 Jul 22 | r25        | Nashville SCNashville SC | 2 - 2 | Portland TimbersPortland Timb |
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| 09 Jul 22 | r26        | Seattle Sounders FCSeattle Sound | 0 - 3 | Portland TimbersPortland Timb |
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| 18 Jul 22 | r29        | Portland TimbersPortland Timb | 1 - 1 | Vancouver WhitecapsVancouver Whi |
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| 24 Jul 22 | r31        | Portland TimbersPortland Timb | 2 - 1 | San Jose EarthquakesSan Jose Eart |
| 30 Jul 22 | r31        | Minnesota UnitedMinnesota Uni | 4 - 4 | Portland TimbersPortland Timb |
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| 04 Aug 22 | r33        | Portland TimbersPortland Timb | 1 - 1 | Nashville SCNashville SC |
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| 07 Aug 22 | r34        | Portland TimbersPortland Timb | 1 - 1 | FC DallasFC Dallas |
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| 14 Aug 22 | r35        | Toronto FCToronto FC | 3 - 1 | Portland TimbersPortland Timb |
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| 22 Aug 22 | r38        | Sporting Kansas CitySporting Kans | 4 - 1 | Portland TimbersPortland Timb |
| 27 Aug 22 | r38        | Portland TimbersPortland Timb | 2 - 1 | Seattle Sounders FCSeattle Sound |
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| 01 Sep 22 | r40        | Austin FCAustin FC | 1 - 2 | Portland TimbersPortland Timb |
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| 04 Sep 22 | r41        | Portland TimbersPortland Timb | 2 - 1 | Atlanta UnitedAtlanta Unite |
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| 11 Sep 22 | r43        | Portland TimbersPortland Timb | 1 - 0 | Minnesota UnitedMinnesota Uni |
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| 18 Sep 22 | r45        | Columbus CrewColumbus Crew | 1 - 1 | Portland TimbersPortland Timb |
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| 02 Oct 22 | r46        | Portland TimbersPortland Timb | 1 - 2 | Los Angeles FCLos Angeles F |
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| 09 Oct 22 | r48        | Real Salt LakeReal Salt Lak | 3 - 1 | Portland TimbersPortland Timb |