

Team 2022 Scheduals| 27 Feb |
r01 | Portland TimbersPortland Timb | 2 - 2 | New England Rev.New England R |
| 07 Mar |
r03 | Los Angeles FCLos Angeles F | 1 - 1 | Portland TimbersPortland Timb |
| 13 Mar |
r04 | Portland TimbersPortland Timb | 1 - 0 | Austin FCAustin FC |
| 20 Mar |
r06 | FC DallasFC Dallas | 4 - 1 | Portland TimbersPortland Timb |
| 27 Mar |
r06 | Portland TimbersPortland Timb | 1 - 1 | Orlando CityOrlando City |
| 03 Apr |
r08 | Portland TimbersPortland Timb | 1 - 3 | L.A. GalaxyL.A. Galaxy |
| 10 Apr |
r09 | Vancouver WhitecapsVancouver Whi | 2 - 3 | Portland TimbersPortland Timb |
| 16 Apr |
r10 | Houston DynamoHouston Dynam | 0 - 0 | Portland TimbersPortland Timb |
| 24 Apr |
r11 | Portland TimbersPortland Timb | 0 - 0 | Real Salt LakeReal Salt Lak |
| 01 May |
r13 | Colorado RapidsColorado Rapi | 2 - 0 | Portland TimbersPortland Timb |
| 07 May |
r14 | New York Red BullsNew York Red | 1 - 1 | Portland TimbersPortland Timb |
| 15 May |
r16 | Portland TimbersPortland Timb | 7 - 2 | Sporting Kansas CitySporting Kans |
| 19 May |
r17 | San Jose EarthquakesSan Jose Eart | 3 - 2 | Portland TimbersPortland Timb |
| 23 May |
r19 | Portland TimbersPortland Timb | 0 - 2 | Philadelphia UnionPhiladelphia |
| 29 May |
r20 | Inter MiamiInter Miami | 2 - 1 | Portland TimbersPortland Timb |
| 18 Jun |
r21 | L.A. GalaxyL.A. Galaxy | 1 - 1 | Portland TimbersPortland Timb |
| 26 Jun |
r23 | Portland TimbersPortland Timb | 3 - 0 | Colorado RapidsColorado Rapi |
| 30 Jun |
r24 | Portland TimbersPortland Timb | 2 - 1 | Houston DynamoHouston Dynam |
| 04 Jul |
r25 | Nashville SCNashville SC | 2 - 2 | Portland TimbersPortland Timb |
| 09 Jul |
r26 | Seattle Sounders FCSeattle Sound | 0 - 3 | Portland TimbersPortland Timb |
| 18 Jul |
r29 | Portland TimbersPortland Timb | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 24 Jul |
r31 | Portland TimbersPortland Timb | 2 - 1 | San Jose EarthquakesSan Jose Eart |
| 30 Jul |
r31 | Minnesota UnitedMinnesota Uni | 4 - 4 | Portland TimbersPortland Timb |
| 04 Aug |
r33 | Portland TimbersPortland Timb | 1 - 1 | Nashville SCNashville SC |
| 07 Aug |
r34 | Portland TimbersPortland Timb | 1 - 1 | FC DallasFC Dallas |
| 13 Aug |
r35 | Toronto FCToronto FC | 3 - 1 | Portland TimbersPortland Timb |
| 21 Aug |
r38 | Sporting Kansas CitySporting Kans | 4 - 1 | Portland TimbersPortland Timb |
| 27 Aug |
r38 | Portland TimbersPortland Timb | 2 - 1 | Seattle Sounders FCSeattle Sound |
| 01 Sep |
r40 | Austin FCAustin FC | 1 - 2 | Portland TimbersPortland Timb |
| 04 Sep |
r41 | Portland TimbersPortland Timb | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 11 Sep |
r43 | Portland TimbersPortland Timb | 1 - 0 | Minnesota UnitedMinnesota Uni |
| 18 Sep |
r45 | Columbus CrewColumbus Crew | 1 - 1 | Portland TimbersPortland Timb |
| 02 Oct |
r46 | Portland TimbersPortland Timb | 1 - 2 | Los Angeles FCLos Angeles F |
| 09 Oct |
r48 | Real Salt LakeReal Salt Lak | 3 - 1 | Portland TimbersPortland Timb |