| 26 Feb 22 | r01        | Philadelphia UnionPhiladelphia | 1 - 1 | Minnesota UnitedMinnesota Uni |
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| 05 Mar 22 | r02        | CF MontréalCF Montréal | 1 - 2 | Philadelphia UnionPhiladelphia |
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| 13 Mar 22 | r04        | Philadelphia UnionPhiladelphia | 2 - 0 | San Jose EarthquakesSan Jose Eart |
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| 19 Mar 22 | r05        | New York CityNew York City | 0 - 2 | Philadelphia UnionPhiladelphia |
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| 04 Apr 22 | r07        | Philadelphia UnionPhiladelphia | 2 - 0 | Charlotte FCCharlotte FC |
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| 09 Apr 22 | r08        | Philadelphia UnionPhiladelphia | 1 - 0 | Columbus CrewColumbus Crew |
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| 17 Apr 22 | r10        | Toronto FCToronto FC | 2 - 1 | Philadelphia UnionPhiladelphia |
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| 23 Apr 22 | r11        | Philadelphia UnionPhiladelphia | 1 - 1 | CF MontréalCF Montréal |
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| 01 May 22 | r13        | Nashville SCNashville SC | 1 - 1 | Philadelphia UnionPhiladelphia |
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| 08 May 22 | r14        | Los Angeles FCLos Angeles F | 2 - 2 | Philadelphia UnionPhiladelphia |
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| 15 May 22 | r15        | Philadelphia UnionPhiladelphia | 1 - 1 | New York Red BullsNew York Red |
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| 19 May 22 | r17        | Philadelphia UnionPhiladelphia | 0 - 0 | Inter MiamiInter Miami |
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| 23 May 22 | r19        | Portland TimbersPortland Timb | 0 - 2 | Philadelphia UnionPhiladelphia |
| 29 May 22 | r19        | New England Rev.New England R | 1 - 1 | Philadelphia UnionPhiladelphia |
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| 19 Jun 22 | r21        | Philadelphia UnionPhiladelphia | 1 - 1 | FC CincinnatiFC Cincinnati |
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| 26 Jun 22 | r23        | Philadelphia UnionPhiladelphia | 2 - 1 | New York CityNew York City |
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| 30 Jun 22 | r24        | Chicago FireChicago Fire | 1 - 0 | Philadelphia UnionPhiladelphia |
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| 04 Jul 22 | r25        | Columbus CrewColumbus Crew | 0 - 0 | Philadelphia UnionPhiladelphia |
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| 09 Jul 22 | r26        | Philadelphia UnionPhiladelphia | 7 - 0 | DC UnitedDC United |
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| 14 Jul 22 | r28        | Inter MiamiInter Miami | 1 - 2 | Philadelphia UnionPhiladelphia |
| 17 Jul 22 | r28        | Philadelphia UnionPhiladelphia | 2 - 1 | New England Rev.New England R |
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| 24 Jul 22 | r30        | Orlando CityOrlando City | 0 - 1 | Philadelphia UnionPhiladelphia |
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| 31 Jul 22 | r32        | Philadelphia UnionPhiladelphia | 6 - 0 | Houston DynamoHouston Dynam |
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| 07 Aug 22 | r33        | FC CincinnatiFC Cincinnati | 3 - 1 | Philadelphia UnionPhiladelphia |
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| 14 Aug 22 | r35        | Philadelphia UnionPhiladelphia | 4 - 1 | Chicago FireChicago Fire |
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| 18 Aug 22 | r36        | FC DallasFC Dallas | 1 - 0 | Philadelphia UnionPhiladelphia |
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| 21 Aug 22 | r37        | DC UnitedDC United | 0 - 6 | Philadelphia UnionPhiladelphia |
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| 28 Aug 22 | r38        | Philadelphia UnionPhiladelphia | 6 - 0 | Colorado RapidsColorado Rapi |
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| 01 Sep 22 | r40        | Philadelphia UnionPhiladelphia | 4 - 1 | Atlanta UnitedAtlanta Unite |
| 03 Sep 22 | r40        | New York Red BullsNew York Red | 0 - 2 | Philadelphia UnionPhiladelphia |
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| 11 Sep 22 | r42        | Philadelphia UnionPhiladelphia | 5 - 1 | Orlando CityOrlando City |
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| 17 Sep 22 | r44        | Atlanta UnitedAtlanta Unite | 0 - 0 | Philadelphia UnionPhiladelphia |
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| 01 Oct 22 | r46        | Charlotte FCCharlotte FC | 4 - 0 | Philadelphia UnionPhiladelphia |
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| 09 Oct 22 | r47        | Philadelphia UnionPhiladelphia | 4 - 0 | Toronto FCToronto FC |
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| 21 Oct 22 | QF        | Philadelphia UnionPhiladelphia | 1 - 0 | FC CincinnatiFC Cincinnati |
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| 31 Oct 22 | SF        | Philadelphia UnionPhiladelphia | 3 - 1 | New York CityNew York City |
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| 05 Nov 22 | Final        | Los Angeles FCLos Angeles F | 3 - 3 | Philadelphia UnionPhiladelphia |