| 26 Feb 22 | r01        | Philadelphia UnionPhiladelphia | 1 - 1 | Minnesota UnitedMinnesota Uni |
| 26 Feb 22 | r01 | Columbus CrewColumbus Crew | 4 - 0 | Vancouver WhitecapsVancouver Whi |
| 26 Feb 22 | r01 | Los Angeles FCLos Angeles F | 3 - 0 | Colorado RapidsColorado Rapi |
| 26 Feb 22 | r01 | FC DallasFC Dallas | 1 - 1 | Toronto FCToronto FC |
| 26 Feb 22 | r01 | DC UnitedDC United | 3 - 0 | Charlotte FCCharlotte FC |
| 26 Feb 22 | r01 | Austin FCAustin FC | 5 - 0 | FC CincinnatiFC Cincinnati |
| 26 Feb 22 | r01 | Inter MiamiInter Miami | 0 - 0 | Chicago FireChicago Fire |
| 26 Feb 22 | r01 | San Jose EarthquakesSan Jose Eart | 1 - 3 | New York Red BullsNew York Red |
| 27 Feb 22 | r01 | Portland TimbersPortland Timb | 2 - 2 | New England Rev.New England R |
| 27 Feb 22 | r01 | Orlando CityOrlando City | 2 - 0 | CF MontréalCF Montréal |
| |
| 27 Feb 22 | r02 | Atlanta UnitedAtlanta Unite | 3 - 1 | Sporting Kansas CitySporting Kans |
| 27 Feb 22 | r02 | L.A. GalaxyL.A. Galaxy | 1 - 0 | New York CityNew York City |
| 28 Feb 22 | r02 | Houston DynamoHouston Dynam | 0 - 0 | Real Salt LakeReal Salt Lak |
| 28 Feb 22 | r02 | Seattle Sounders FCSeattle Sound | 0 - 1 | Nashville SCNashville SC |
| 05 Mar 22 | r02 | New England Rev.New England R | 1 - 0 | FC DallasFC Dallas |
| 05 Mar 22 | r02 | Toronto FCToronto FC | 1 - 4 | New York Red BullsNew York Red |
| 05 Mar 22 | r02 | Sporting Kansas CitySporting Kans | 1 - 0 | Houston DynamoHouston Dynam |
| 05 Mar 22 | r02 | CF MontréalCF Montréal | 1 - 2 | Philadelphia UnionPhiladelphia |
| 05 Mar 22 | r02 | San Jose EarthquakesSan Jose Eart | 3 - 3 | Columbus CrewColumbus Crew |
| 05 Mar 22 | r02 | FC CincinnatiFC Cincinnati | 0 - 1 | DC UnitedDC United |
| |
| 05 Mar 22 | r03 | Chicago FireChicago Fire | 0 - 0 | Orlando CityOrlando City |
| 05 Mar 22 | r03 | Minnesota UnitedMinnesota Uni | 1 - 1 | Nashville SCNashville SC |
| 05 Mar 22 | r03 | Colorado RapidsColorado Rapi | 3 - 0 | Atlanta UnitedAtlanta Unite |
| 05 Mar 22 | r03 | Real Salt LakeReal Salt Lak | 1 - 0 | Seattle Sounders FCSeattle Sound |
| 05 Mar 22 | r03 | Vancouver WhitecapsVancouver Whi | 0 - 0 | New York CityNew York City |
| 06 Mar 22 | r03 | Charlotte FCCharlotte FC | 0 - 1 | L.A. GalaxyL.A. Galaxy |
| 06 Mar 22 | r03 | Austin FCAustin FC | 5 - 1 | Inter MiamiInter Miami |
| 07 Mar 22 | r03 | Los Angeles FCLos Angeles F | 1 - 1 | Portland TimbersPortland Timb |
| 12 Mar 22 | r03 | New York CityNew York City | 4 - 1 | CF MontréalCF Montréal |
| 12 Mar 22 | r03 | Columbus CrewColumbus Crew | 2 - 1 | Toronto FCToronto FC |
| |
| 12 Mar 22 | r04 | Inter MiamiInter Miami | 0 - 2 | Los Angeles FCLos Angeles F |
| 12 Mar 22 | r04 | Seattle Sounders FCSeattle Sound | 3 - 2 | L.A. GalaxyL.A. Galaxy |
| 12 Mar 22 | r04 | Houston DynamoHouston Dynam | 2 - 1 | Vancouver WhitecapsVancouver Whi |
| 13 Mar 22 | r04 | DC UnitedDC United | 0 - 2 | Chicago FireChicago Fire |
| 13 Mar 22 | r04 | New England Rev.New England R | 2 - 3 | Real Salt LakeReal Salt Lak |
| 13 Mar 22 | r04 | Orlando CityOrlando City | 1 - 2 | FC CincinnatiFC Cincinnati |
| 13 Mar 22 | r04 | Philadelphia UnionPhiladelphia | 2 - 0 | San Jose EarthquakesSan Jose Eart |
| 13 Mar 22 | r04 | FC DallasFC Dallas | 2 - 0 | Nashville SCNashville SC |
| 13 Mar 22 | r04 | Colorado RapidsColorado Rapi | 2 - 0 | Sporting Kansas CitySporting Kans |
| 13 Mar 22 | r04 | Portland TimbersPortland Timb | 1 - 0 | Austin FCAustin FC |
| |
| 13 Mar 22 | r05 | Atlanta UnitedAtlanta Unite | 2 - 1 | Charlotte FCCharlotte FC |
| 13 Mar 22 | r05 | New York Red BullsNew York Red | 0 - 1 | Minnesota UnitedMinnesota Uni |
| 19 Mar 22 | r05 | FC CincinnatiFC Cincinnati | 3 - 1 | Inter MiamiInter Miami |
| 19 Mar 22 | r05 | New York CityNew York City | 0 - 2 | Philadelphia UnionPhiladelphia |
| 19 Mar 22 | r05 | Toronto FCToronto FC | 2 - 1 | DC UnitedDC United |
| 19 Mar 22 | r05 | L.A. GalaxyL.A. Galaxy | 0 - 1 | Orlando CityOrlando City |
| 19 Mar 22 | r05 | Atlanta UnitedAtlanta Unite | 3 - 3 | CF MontréalCF Montréal |
| 19 Mar 22 | r05 | Chicago FireChicago Fire | 3 - 1 | Sporting Kansas CitySporting Kans |
| 19 Mar 22 | r05 | Charlotte FCCharlotte FC | 3 - 1 | New England Rev.New England R |
| 20 Mar 22 | r05 | Minnesota UnitedMinnesota Uni | 1 - 0 | San Jose EarthquakesSan Jose Eart |
| |
| 20 Mar 22 | r06 | Houston DynamoHouston Dynam | 1 - 1 | Colorado RapidsColorado Rapi |
| 20 Mar 22 | r06 | FC DallasFC Dallas | 4 - 1 | Portland TimbersPortland Timb |
| 20 Mar 22 | r06 | Real Salt LakeReal Salt Lak | 2 - 1 | Nashville SCNashville SC |
| 20 Mar 22 | r06 | New York Red BullsNew York Red | 1 - 1 | Columbus CrewColumbus Crew |
| 20 Mar 22 | r06 | Austin FCAustin FC | 1 - 1 | Seattle Sounders FCSeattle Sound |
| 21 Mar 22 | r06 | Los Angeles FCLos Angeles F | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| 26 Mar 22 | r06 | Charlotte FCCharlotte FC | 2 - 0 | FC CincinnatiFC Cincinnati |
| 27 Mar 22 | r06 | Portland TimbersPortland Timb | 1 - 1 | Orlando CityOrlando City |
| 27 Mar 22 | r06 | Sporting Kansas CitySporting Kans | 1 - 0 | Real Salt LakeReal Salt Lak |
| 02 Apr 22 | r06 | Chicago FireChicago Fire | 0 - 0 | FC DallasFC Dallas |
| |
| 02 Apr 22 | r07 | FC CincinnatiFC Cincinnati | 3 - 4 | CF MontréalCF Montréal |
| 02 Apr 22 | r07 | Toronto FCToronto FC | 2 - 1 | New York CityNew York City |
| 02 Apr 22 | r07 | Columbus CrewColumbus Crew | 0 - 1 | Nashville SCNashville SC |
| 03 Apr 22 | r07 | Inter MiamiInter Miami | 1 - 3 | Houston DynamoHouston Dynam |
| 03 Apr 22 | r07 | Minnesota UnitedMinnesota Uni | 1 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 03 Apr 22 | r08 | Vancouver WhitecapsVancouver Whi | 1 - 0 | Sporting Kansas CitySporting Kans |
| 03 Apr 22 | r08 | Colorado RapidsColorado Rapi | 1 - 1 | Real Salt LakeReal Salt Lak |
| 03 Apr 22 | r08 | Portland TimbersPortland Timb | 1 - 3 | L.A. GalaxyL.A. Galaxy |
| |
| 04 Apr 22 | r07 | DC UnitedDC United | 0 - 1 | Atlanta UnitedAtlanta Unite |
| 04 Apr 22 | r07 | New England Rev.New England R | 0 - 1 | New York Red BullsNew York Red |
| 04 Apr 22 | r07 | Orlando CityOrlando City | 2 - 4 | Los Angeles FCLos Angeles F |
| 04 Apr 22 | r07 | Philadelphia UnionPhiladelphia | 2 - 0 | Charlotte FCCharlotte FC |
| 04 Apr 22 | r07 | San Jose EarthquakesSan Jose Eart | 2 - 2 | Austin FCAustin FC |
| |
| 09 Apr 22 | r08 | Orlando CityOrlando City | 1 - 0 | Chicago FireChicago Fire |
| 09 Apr 22 | r08 | New York Red BullsNew York Red | 1 - 2 | CF MontréalCF Montréal |
| 09 Apr 22 | r08 | Inter MiamiInter Miami | 3 - 2 | New England Rev.New England R |
| 09 Apr 22 | r08 | Philadelphia UnionPhiladelphia | 1 - 0 | Columbus CrewColumbus Crew |
| 10 Apr 22 | r08 | L.A. GalaxyL.A. Galaxy | 2 - 1 | Los Angeles FCLos Angeles F |
| |
| 10 Apr 22 | r09 | Real Salt LakeReal Salt Lak | 2 - 2 | Toronto FCToronto FC |
| 10 Apr 22 | r09 | FC DallasFC Dallas | 3 - 1 | Colorado RapidsColorado Rapi |
| 10 Apr 22 | r09 | Houston DynamoHouston Dynam | 4 - 3 | San Jose EarthquakesSan Jose Eart |
| 10 Apr 22 | r09 | Sporting Kansas CitySporting Kans | 1 - 2 | Nashville SCNashville SC |
| 10 Apr 22 | r09 | Vancouver WhitecapsVancouver Whi | 2 - 3 | Portland TimbersPortland Timb |
| |
| 10 Apr 22 | r08 | Charlotte FCCharlotte FC | 1 - 0 | Atlanta UnitedAtlanta Unite |
| |
| 11 Apr 22 | r09 | Austin FCAustin FC | 1 - 0 | Minnesota UnitedMinnesota Uni |
| 16 Apr 22 | r09 | CF MontréalCF Montréal | 2 - 1 | Vancouver WhitecapsVancouver Whi |
| 16 Apr 22 | r09 | San Jose EarthquakesSan Jose Eart | 2 - 2 | Nashville SCNashville SC |
| 16 Apr 22 | r09 | Atlanta UnitedAtlanta Unite | 0 - 0 | FC CincinnatiFC Cincinnati |
| |
| 16 Apr 22 | r10 | Houston DynamoHouston Dynam | 0 - 0 | Portland TimbersPortland Timb |
| 16 Apr 22 | r10 | New York Red BullsNew York Red | 0 - 0 | FC DallasFC Dallas |
| 17 Apr 22 | r10 | Columbus CrewColumbus Crew | 0 - 2 | Orlando CityOrlando City |
| 17 Apr 22 | r10 | DC UnitedDC United | 2 - 3 | Austin FCAustin FC |
| 17 Apr 22 | r10 | New England Rev.New England R | 2 - 1 | Charlotte FCCharlotte FC |
| 17 Apr 22 | r10 | Toronto FCToronto FC | 2 - 1 | Philadelphia UnionPhiladelphia |
| 17 Apr 22 | r10 | Chicago FireChicago Fire | 0 - 0 | L.A. GalaxyL.A. Galaxy |
| 17 Apr 22 | r10 | Minnesota UnitedMinnesota Uni | 3 - 1 | Colorado RapidsColorado Rapi |
| 17 Apr 22 | r10 | Seattle Sounders FCSeattle Sound | 0 - 1 | Inter MiamiInter Miami |
| 17 Apr 22 | r10 | New York CityNew York City | 6 - 0 | Real Salt LakeReal Salt Lak |
| |
| 17 Apr 22 | r11 | Los Angeles FCLos Angeles F | 3 - 1 | Sporting Kansas CitySporting Kans |
| 23 Apr 22 | r11 | FC DallasFC Dallas | 2 - 1 | Houston DynamoHouston Dynam |
| 23 Apr 22 | r11 | Philadelphia UnionPhiladelphia | 1 - 1 | CF MontréalCF Montréal |
| 23 Apr 22 | r11 | Minnesota UnitedMinnesota Uni | 3 - 0 | Chicago FireChicago Fire |
| 24 Apr 22 | r11 | DC UnitedDC United | 3 - 2 | New England Rev.New England R |
| 24 Apr 22 | r11 | Austin FCAustin FC | 3 - 0 | Vancouver WhitecapsVancouver Whi |
| 24 Apr 22 | r11 | Sporting Kansas CitySporting Kans | 0 - 0 | Columbus CrewColumbus Crew |
| 24 Apr 22 | r11 | Colorado RapidsColorado Rapi | 0 - 0 | Charlotte FCCharlotte FC |
| 24 Apr 22 | r11 | Portland TimbersPortland Timb | 0 - 0 | Real Salt LakeReal Salt Lak |
| |
| 24 Apr 22 | r12 | San Jose EarthquakesSan Jose Eart | 4 - 3 | Seattle Sounders FCSeattle Sound |
| |
| 24 Apr 22 | r11 | L.A. GalaxyL.A. Galaxy | 1 - 0 | Nashville SCNashville SC |
| |
| 24 Apr 22 | r12 | Inter MiamiInter Miami | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 24 Apr 22 | r12 | Orlando CityOrlando City | 0 - 3 | New York Red BullsNew York Red |
| 24 Apr 22 | r12 | FC CincinnatiFC Cincinnati | 1 - 2 | Los Angeles FCLos Angeles F |
| 24 Apr 22 | r12 | New York CityNew York City | 5 - 4 | Toronto FCToronto FC |
| 30 Apr 22 | r12 | Houston DynamoHouston Dynam | 1 - 2 | Austin FCAustin FC |
| 30 Apr 22 | r12 | Toronto FCToronto FC | 1 - 2 | FC CincinnatiFC Cincinnati |
| 30 Apr 22 | r12 | Real Salt LakeReal Salt Lak | 1 - 0 | L.A. GalaxyL.A. Galaxy |
| 30 Apr 22 | r12 | CF MontréalCF Montréal | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 01 May 22 | r12 | New England Rev.New England R | 2 - 0 | Inter MiamiInter Miami |
| |
| 01 May 22 | r13 | Columbus CrewColumbus Crew | 3 - 0 | DC UnitedDC United |
| 01 May 22 | r13 | Orlando CityOrlando City | 2 - 1 | Charlotte FCCharlotte FC |
| 01 May 22 | r13 | Chicago FireChicago Fire | 1 - 2 | New York Red BullsNew York Red |
| 01 May 22 | r13 | Sporting Kansas CitySporting Kans | 2 - 2 | FC DallasFC Dallas |
| 01 May 22 | r13 | Colorado RapidsColorado Rapi | 2 - 0 | Portland TimbersPortland Timb |
| 01 May 22 | r13 | New York CityNew York City | 3 - 0 | San Jose EarthquakesSan Jose Eart |
| 01 May 22 | r13 | Nashville SCNashville SC | 1 - 1 | Philadelphia UnionPhiladelphia |
| 02 May 22 | r13 | Los Angeles FCLos Angeles F | 2 - 0 | Minnesota UnitedMinnesota Uni |
| |
| 05 May 22 | r16 | FC CincinnatiFC Cincinnati | 2 - 0 | Toronto FCToronto FC |
| |
| 07 May 22 | r14 | Charlotte FCCharlotte FC | 1 - 0 | Inter MiamiInter Miami |
| 07 May 22 | r14 | CF MontréalCF Montréal | 4 - 1 | Orlando CityOrlando City |
| 07 May 22 | r14 | Atlanta UnitedAtlanta Unite | 4 - 1 | Chicago FireChicago Fire |
| 07 May 22 | r14 | New York Red BullsNew York Red | 1 - 1 | Portland TimbersPortland Timb |
| 08 May 22 | r14 | New York CityNew York City | 0 - 0 | Sporting Kansas CitySporting Kans |
| 08 May 22 | r14 | DC UnitedDC United | 2 - 0 | Houston DynamoHouston Dynam |
| 08 May 22 | r14 | New England Rev.New England R | 2 - 2 | Columbus CrewColumbus Crew |
| 08 May 22 | r14 | Minnesota UnitedMinnesota Uni | 0 - 1 | FC CincinnatiFC Cincinnati |
| 08 May 22 | r14 | FC DallasFC Dallas | 2 - 0 | Seattle Sounders FCSeattle Sound |
| |
| 08 May 22 | r13 | San Jose EarthquakesSan Jose Eart | 1 - 0 | Colorado RapidsColorado Rapi |
| |
| 08 May 22 | r14 | Los Angeles FCLos Angeles F | 2 - 2 | Philadelphia UnionPhiladelphia |
| |
| 08 May 22 | r15 | Vancouver WhitecapsVancouver Whi | 1 - 0 | Toronto FCToronto FC |
| 08 May 22 | r15 | Nashville SCNashville SC | 2 - 0 | Real Salt LakeReal Salt Lak |
| 09 May 22 | r15 | Austin FCAustin FC | 0 - 1 | L.A. GalaxyL.A. Galaxy |
| 14 May 22 | r15 | Toronto FCToronto FC | 0 - 1 | Orlando CityOrlando City |
| 14 May 22 | r15 | Colorado RapidsColorado Rapi | 2 - 0 | Los Angeles FCLos Angeles F |
| 15 May 22 | r15 | Charlotte FCCharlotte FC | 0 - 2 | CF MontréalCF Montréal |
| 15 May 22 | r15 | New York CityNew York City | 2 - 0 | Columbus CrewColumbus Crew |
| 15 May 22 | r15 | Vancouver WhitecapsVancouver Whi | 3 - 3 | San Jose EarthquakesSan Jose Eart |
| 15 May 22 | r15 | Philadelphia UnionPhiladelphia | 1 - 1 | New York Red BullsNew York Red |
| 15 May 22 | r15 | Chicago FireChicago Fire | 1 - 2 | FC CincinnatiFC Cincinnati |
| |
| 15 May 22 | r16 | Inter MiamiInter Miami | 2 - 2 | DC UnitedDC United |
| 15 May 22 | r16 | Houston DynamoHouston Dynam | 2 - 0 | Nashville SCNashville SC |
| 15 May 22 | r16 | Real Salt LakeReal Salt Lak | 2 - 1 | Austin FCAustin FC |
| 15 May 22 | r16 | Portland TimbersPortland Timb | 7 - 2 | Sporting Kansas CitySporting Kans |
| 15 May 22 | r16 | L.A. GalaxyL.A. Galaxy | 1 - 3 | FC DallasFC Dallas |
| 15 May 22 | r16 | Atlanta UnitedAtlanta Unite | 2 - 2 | New England Rev.New England R |
| 15 May 22 | r16 | Seattle Sounders FCSeattle Sound | 3 - 1 | Minnesota UnitedMinnesota Uni |
| 18 May 22 | r16 | New York Red BullsNew York Red | 3 - 3 | Chicago FireChicago Fire |
| 19 May 22 | r16 | DC UnitedDC United | 0 - 2 | New York CityNew York City |
| |
| 19 May 22 | r17 | Philadelphia UnionPhiladelphia | 0 - 0 | Inter MiamiInter Miami |
| 19 May 22 | r17 | Minnesota UnitedMinnesota Uni | 1 - 1 | L.A. GalaxyL.A. Galaxy |
| 19 May 22 | r17 | Houston DynamoHouston Dynam | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 19 May 22 | r17 | Sporting Kansas CitySporting Kans | 2 - 1 | Colorado RapidsColorado Rapi |
| 19 May 22 | r17 | Nashville SCNashville SC | 2 - 1 | CF MontréalCF Montréal |
| 19 May 22 | r17 | Vancouver WhitecapsVancouver Whi | 2 - 1 | FC DallasFC Dallas |
| 19 May 22 | r17 | Los Angeles FCLos Angeles F | 1 - 2 | Austin FCAustin FC |
| 19 May 22 | r17 | San Jose EarthquakesSan Jose Eart | 3 - 2 | Portland TimbersPortland Timb |
| |
| 21 May 22 | r18 | FC CincinnatiFC Cincinnati | 2 - 3 | New England Rev.New England R |
| |
| 21 May 22 | r17 | DC UnitedDC United | 2 - 2 | Toronto FCToronto FC |
| |
| 22 May 22 | r18 | Nashville SCNashville SC | 2 - 2 | Atlanta UnitedAtlanta Unite |
| |
| 22 May 22 | r17 | Columbus CrewColumbus Crew | 0 - 2 | Los Angeles FCLos Angeles F |
| |
| 22 May 22 | r18 | CF MontréalCF Montréal | 1 - 2 | Real Salt LakeReal Salt Lak |
| 22 May 22 | r18 | Charlotte FCCharlotte FC | 2 - 1 | Vancouver WhitecapsVancouver Whi |
| 22 May 22 | r18 | New York CityNew York City | 1 - 0 | Chicago FireChicago Fire |
| 22 May 22 | r18 | Inter MiamiInter Miami | 2 - 0 | New York Red BullsNew York Red |
| 23 May 22 | r18 | FC DallasFC Dallas | 1 - 2 | Minnesota UnitedMinnesota Uni |
| 23 May 22 | r18 | San Jose EarthquakesSan Jose Eart | 1 - 1 | Sporting Kansas CitySporting Kans |
| 23 May 22 | r18 | Austin FCAustin FC | 2 - 2 | Orlando CityOrlando City |
| 23 May 22 | r18 | Colorado RapidsColorado Rapi | 1 - 0 | Seattle Sounders FCSeattle Sound |
| |
| 23 May 22 | r19 | L.A. GalaxyL.A. Galaxy | 0 - 3 | Houston DynamoHouston Dynam |
| 23 May 22 | r19 | Portland TimbersPortland Timb | 0 - 2 | Philadelphia UnionPhiladelphia |
| 28 May 22 | r19 | Los Angeles FCLos Angeles F | 3 - 2 | San Jose EarthquakesSan Jose Eart |
| 28 May 22 | r19 | New York Red BullsNew York Red | 4 - 1 | DC UnitedDC United |
| 29 May 22 | r19 | Atlanta UnitedAtlanta Unite | 1 - 2 | Columbus CrewColumbus Crew |
| 29 May 22 | r19 | Toronto FCToronto FC | 3 - 2 | Chicago FireChicago Fire |
| 29 May 22 | r19 | CF MontréalCF Montréal | 4 - 3 | FC CincinnatiFC Cincinnati |
| 29 May 22 | r19 | New England Rev.New England R | 1 - 1 | Philadelphia UnionPhiladelphia |
| 29 May 22 | r19 | Orlando CityOrlando City | 1 - 3 | FC DallasFC Dallas |
| |
| 29 May 22 | r20 | Inter MiamiInter Miami | 2 - 1 | Portland TimbersPortland Timb |
| 29 May 22 | r20 | Minnesota UnitedMinnesota Uni | 0 - 1 | New York CityNew York City |
| 29 May 22 | r20 | Colorado RapidsColorado Rapi | 1 - 3 | Nashville SCNashville SC |
| 29 May 22 | r20 | Sporting Kansas CitySporting Kans | 0 - 1 | Vancouver WhitecapsVancouver Whi |
| 29 May 22 | r20 | Real Salt LakeReal Salt Lak | 3 - 0 | Houston DynamoHouston Dynam |
| |
| 29 May 22 | r19 | L.A. GalaxyL.A. Galaxy | 4 - 1 | Austin FCAustin FC |
| |
| 30 May 22 | r20 | Seattle Sounders FCSeattle Sound | 2 - 1 | Charlotte FCCharlotte FC |
| 05 Jun 22 | r20 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Real Salt LakeReal Salt Lak |
| 11 Jun 22 | r20 | Charlotte FCCharlotte FC | 2 - 0 | New York Red BullsNew York Red |
| 12 Jun 22 | r20 | Nashville SCNashville SC | 0 - 0 | San Jose EarthquakesSan Jose Eart |
| 12 Jun 22 | r20 | Sporting Kansas CitySporting Kans | 1 - 2 | New England Rev.New England R |
| |
| 15 Jun 22 | r13 | Seattle Sounders FCSeattle Sound | 4 - 0 | Vancouver WhitecapsVancouver Whi |
| |
| 16 Jun 22 | r24 | New England Rev.New England R | 1 - 1 | Orlando CityOrlando City |
| |
| 18 Jun 22 | r21 | Seattle Sounders FCSeattle Sound | 1 - 1 | Los Angeles FCLos Angeles F |
| 18 Jun 22 | r21 | L.A. GalaxyL.A. Galaxy | 1 - 1 | Portland TimbersPortland Timb |
| 18 Jun 22 | r21 | New York Red BullsNew York Red | 2 - 0 | Toronto FCToronto FC |
| 19 Jun 22 | r21 | Columbus CrewColumbus Crew | 1 - 1 | Charlotte FCCharlotte FC |
| 19 Jun 22 | r21 | CF MontréalCF Montréal | 0 - 1 | Austin FCAustin FC |
| 19 Jun 22 | r21 | Orlando CityOrlando City | 2 - 1 | Houston DynamoHouston Dynam |
| 19 Jun 22 | r21 | Philadelphia UnionPhiladelphia | 1 - 1 | FC CincinnatiFC Cincinnati |
| 19 Jun 22 | r21 | Chicago FireChicago Fire | 1 - 0 | DC UnitedDC United |
| 19 Jun 22 | r21 | FC DallasFC Dallas | 0 - 2 | Vancouver WhitecapsVancouver Whi |
| |
| 19 Jun 22 | r22 | Real Salt LakeReal Salt Lak | 2 - 0 | San Jose EarthquakesSan Jose Eart |
| 19 Jun 22 | r22 | Atlanta UnitedAtlanta Unite | 2 - 0 | Inter MiamiInter Miami |
| |
| 19 Jun 22 | r21 | New England Rev.New England R | 2 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 19 Jun 22 | r22 | New York CityNew York City | 1 - 1 | Colorado RapidsColorado Rapi |
| 19 Jun 22 | r22 | Nashville SCNashville SC | 1 - 2 | Sporting Kansas CitySporting Kans |
| 25 Jun 22 | r22 | FC CincinnatiFC Cincinnati | 1 - 0 | Orlando CityOrlando City |
| 25 Jun 22 | r22 | Seattle Sounders FCSeattle Sound | 3 - 0 | Sporting Kansas CitySporting Kans |
| 25 Jun 22 | r22 | DC UnitedDC United | 1 - 3 | Nashville SCNashville SC |
| 26 Jun 22 | r22 | CF MontréalCF Montréal | 2 - 1 | Charlotte FCCharlotte FC |
| 26 Jun 22 | r22 | Toronto FCToronto FC | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 26 Jun 22 | r22 | Houston DynamoHouston Dynam | 2 - 0 | Chicago FireChicago Fire |
| |
| 26 Jun 22 | r23 | Inter MiamiInter Miami | 2 - 1 | Minnesota UnitedMinnesota Uni |
| 26 Jun 22 | r23 | Austin FCAustin FC | 2 - 2 | FC DallasFC Dallas |
| 26 Jun 22 | r23 | Real Salt LakeReal Salt Lak | 0 - 0 | Columbus CrewColumbus Crew |
| 26 Jun 22 | r23 | Portland TimbersPortland Timb | 3 - 0 | Colorado RapidsColorado Rapi |
| 26 Jun 22 | r23 | Los Angeles FCLos Angeles F | 2 - 0 | New York Red BullsNew York Red |
| 26 Jun 22 | r23 | Philadelphia UnionPhiladelphia | 2 - 1 | New York CityNew York City |
| 27 Jun 22 | r23 | Vancouver WhitecapsVancouver Whi | 0 - 0 | New England Rev.New England R |
| 30 Jun 22 | r23 | FC CincinnatiFC Cincinnati | 4 - 4 | New York CityNew York City |
| 30 Jun 22 | r23 | Toronto FCToronto FC | 1 - 2 | Columbus CrewColumbus Crew |
| |
| 30 Jun 22 | r24 | Chicago FireChicago Fire | 1 - 0 | Philadelphia UnionPhiladelphia |
| 30 Jun 22 | r24 | Seattle Sounders FCSeattle Sound | 1 - 2 | CF MontréalCF Montréal |
| 30 Jun 22 | r24 | Los Angeles FCLos Angeles F | 3 - 1 | FC DallasFC Dallas |
| 30 Jun 22 | r24 | Portland TimbersPortland Timb | 2 - 1 | Houston DynamoHouston Dynam |
| |
| 30 Jun 22 | r33 | L.A. GalaxyL.A. Galaxy | 2 - 3 | Minnesota UnitedMinnesota Uni |
| |
| 01 Jul 22 | r24 | Charlotte FCCharlotte FC | 0 - 1 | Austin FCAustin FC |
| 01 Jul 22 | r24 | New York Red BullsNew York Red | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 03 Jul 22 | r24 | Toronto FCToronto FC | 0 - 2 | Seattle Sounders FCSeattle Sound |
| 03 Jul 22 | r24 | Vancouver WhitecapsVancouver Whi | 1 - 0 | Los Angeles FCLos Angeles F |
| |
| 03 Jul 22 | r25 | New York CityNew York City | 2 - 2 | Atlanta UnitedAtlanta Unite |
| 04 Jul 22 | r25 | Columbus CrewColumbus Crew | 0 - 0 | Philadelphia UnionPhiladelphia |
| 04 Jul 22 | r25 | New England Rev.New England R | 2 - 2 | FC CincinnatiFC Cincinnati |
| |
| 04 Jul 22 | r24 | Minnesota UnitedMinnesota Uni | 3 - 2 | Real Salt LakeReal Salt Lak |
| |
| 04 Jul 22 | r25 | Sporting Kansas CitySporting Kans | 0 - 1 | New York Red BullsNew York Red |
| 04 Jul 22 | r25 | Houston DynamoHouston Dynam | 1 - 2 | Charlotte FCCharlotte FC |
| 04 Jul 22 | r25 | Nashville SCNashville SC | 2 - 2 | Portland TimbersPortland Timb |
| 04 Jul 22 | r25 | San Jose EarthquakesSan Jose Eart | 2 - 1 | Chicago FireChicago Fire |
| 05 Jul 22 | r25 | Orlando CityOrlando City | 3 - 5 | DC UnitedDC United |
| 05 Jul 22 | r25 | Colorado RapidsColorado Rapi | 2 - 3 | Austin FCAustin FC |
| 05 Jul 22 | r25 | FC DallasFC Dallas | 1 - 1 | Inter MiamiInter Miami |
| |
| 05 Jul 22 | r26 | L.A. GalaxyL.A. Galaxy | 4 - 0 | CF MontréalCF Montréal |
| 09 Jul 22 | r26 | Philadelphia UnionPhiladelphia | 7 - 0 | DC UnitedDC United |
| 09 Jul 22 | r26 | Los Angeles FCLos Angeles F | 3 - 2 | L.A. GalaxyL.A. Galaxy |
| 09 Jul 22 | r26 | Vancouver WhitecapsVancouver Whi | 1 - 3 | Minnesota UnitedMinnesota Uni |
| 09 Jul 22 | r26 | New York CityNew York City | 4 - 2 | New England Rev.New England R |
| 09 Jul 22 | r26 | Seattle Sounders FCSeattle Sound | 0 - 3 | Portland TimbersPortland Timb |
| 10 Jul 22 | r26 | Atlanta UnitedAtlanta Unite | 0 - 3 | Austin FCAustin FC |
| 10 Jul 22 | r26 | Charlotte FCCharlotte FC | 4 - 1 | Nashville SCNashville SC |
| 10 Jul 22 | r26 | FC CincinnatiFC Cincinnati | 1 - 1 | New York Red BullsNew York Red |
| 10 Jul 22 | r26 | CF MontréalCF Montréal | 1 - 2 | Sporting Kansas CitySporting Kans |
| |
| 10 Jul 22 | r27 | Toronto FCToronto FC | 2 - 2 | San Jose EarthquakesSan Jose Eart |
| 10 Jul 22 | r27 | Orlando CityOrlando City | 1 - 0 | Inter MiamiInter Miami |
| 10 Jul 22 | r27 | Chicago FireChicago Fire | 2 - 3 | Columbus CrewColumbus Crew |
| 10 Jul 22 | r27 | Houston DynamoHouston Dynam | 2 - 2 | FC DallasFC Dallas |
| 10 Jul 22 | r27 | Real Salt LakeReal Salt Lak | 2 - 2 | Colorado RapidsColorado Rapi |
| 13 Jul 22 | r27 | Austin FCAustin FC | 3 - 1 | Houston DynamoHouston Dynam |
| 14 Jul 22 | r27 | Atlanta UnitedAtlanta Unite | 2 - 1 | Real Salt LakeReal Salt Lak |
| 14 Jul 22 | r27 | Chicago FireChicago Fire | 2 - 0 | Toronto FCToronto FC |
| 14 Jul 22 | r27 | FC CincinnatiFC Cincinnati | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 14 Jul 22 | r27 | DC UnitedDC United | 2 - 2 | Columbus CrewColumbus Crew |
| |
| 14 Jul 22 | r28 | Inter MiamiInter Miami | 1 - 2 | Philadelphia UnionPhiladelphia |
| 14 Jul 22 | r28 | Minnesota UnitedMinnesota Uni | 1 - 1 | Sporting Kansas CitySporting Kans |
| 14 Jul 22 | r28 | Nashville SCNashville SC | 1 - 0 | Seattle Sounders FCSeattle Sound |
| 14 Jul 22 | r28 | Colorado RapidsColorado Rapi | 1 - 1 | Orlando CityOrlando City |
| 14 Jul 22 | r28 | FC DallasFC Dallas | 0 - 1 | New York CityNew York City |
| 14 Jul 22 | r28 | L.A. GalaxyL.A. Galaxy | 2 - 3 | San Jose EarthquakesSan Jose Eart |
| 17 Jul 22 | r28 | CF MontréalCF Montréal | 1 - 0 | Toronto FCToronto FC |
| 17 Jul 22 | r28 | Philadelphia UnionPhiladelphia | 2 - 1 | New England Rev.New England R |
| 17 Jul 22 | r28 | Chicago FireChicago Fire | 1 - 0 | Seattle Sounders FCSeattle Sound |
| 17 Jul 22 | r28 | Inter MiamiInter Miami | 3 - 2 | Charlotte FCCharlotte FC |
| |
| 17 Jul 22 | r29 | Minnesota UnitedMinnesota Uni | 2 - 0 | DC UnitedDC United |
| 17 Jul 22 | r29 | Colorado RapidsColorado Rapi | 2 - 0 | L.A. GalaxyL.A. Galaxy |
| 17 Jul 22 | r29 | FC DallasFC Dallas | 1 - 1 | Austin FCAustin FC |
| 17 Jul 22 | r29 | Atlanta UnitedAtlanta Unite | 1 - 1 | Orlando CityOrlando City |
| 17 Jul 22 | r29 | New York Red BullsNew York Red | 0 - 1 | New York CityNew York City |
| 18 Jul 22 | r29 | Columbus CrewColumbus Crew | 2 - 0 | FC CincinnatiFC Cincinnati |
| 18 Jul 22 | r29 | Nashville SCNashville SC | 1 - 2 | Los Angeles FCLos Angeles F |
| 18 Jul 22 | r29 | Real Salt LakeReal Salt Lak | 3 - 0 | Sporting Kansas CitySporting Kans |
| 18 Jul 22 | r29 | San Jose EarthquakesSan Jose Eart | 1 - 2 | Houston DynamoHouston Dynam |
| 18 Jul 22 | r29 | Portland TimbersPortland Timb | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 24 Jul 22 | r30 | New York CityNew York City | 2 - 0 | Inter MiamiInter Miami |
| 24 Jul 22 | r30 | FC CincinnatiFC Cincinnati | 1 - 1 | Nashville SCNashville SC |
| 24 Jul 22 | r30 | Columbus CrewColumbus Crew | 0 - 0 | New England Rev.New England R |
| 24 Jul 22 | r30 | Orlando CityOrlando City | 0 - 1 | Philadelphia UnionPhiladelphia |
| 24 Jul 22 | r30 | Toronto FCToronto FC | 4 - 0 | Charlotte FCCharlotte FC |
| 24 Jul 22 | r30 | DC UnitedDC United | 1 - 2 | CF MontréalCF Montréal |
| 24 Jul 22 | r30 | Houston DynamoHouston Dynam | 1 - 2 | Minnesota UnitedMinnesota Uni |
| 24 Jul 22 | r30 | Sporting Kansas CitySporting Kans | 0 - 2 | Los Angeles FCLos Angeles F |
| 24 Jul 22 | r30 | Real Salt LakeReal Salt Lak | 0 - 1 | FC DallasFC Dallas |
| 24 Jul 22 | r30 | Seattle Sounders FCSeattle Sound | 2 - 1 | Colorado RapidsColorado Rapi |
| |
| 24 Jul 22 | r31 | Vancouver WhitecapsVancouver Whi | 1 - 3 | Chicago FireChicago Fire |
| 24 Jul 22 | r31 | Portland TimbersPortland Timb | 2 - 1 | San Jose EarthquakesSan Jose Eart |
| 25 Jul 22 | r31 | Austin FCAustin FC | 3 - 4 | New York Red BullsNew York Red |
| 25 Jul 22 | r31 | L.A. GalaxyL.A. Galaxy | 2 - 0 | Atlanta UnitedAtlanta Unite |
| 30 Jul 22 | r31 | Los Angeles FCLos Angeles F | 2 - 1 | Seattle Sounders FCSeattle Sound |
| 30 Jul 22 | r31 | Minnesota UnitedMinnesota Uni | 4 - 4 | Portland TimbersPortland Timb |
| 30 Jul 22 | r31 | Chicago FireChicago Fire | 0 - 0 | Atlanta UnitedAtlanta Unite |
| |
| 31 Jul 22 | r32 | CF MontréalCF Montréal | 0 - 0 | New York CityNew York City |
| 31 Jul 22 | r32 | Philadelphia UnionPhiladelphia | 6 - 0 | Houston DynamoHouston Dynam |
| 31 Jul 22 | r32 | Inter MiamiInter Miami | 4 - 4 | FC CincinnatiFC Cincinnati |
| 31 Jul 22 | r32 | Nashville SCNashville SC | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 31 Jul 22 | r32 | New England Rev.New England R | 0 - 0 | Toronto FCToronto FC |
| 31 Jul 22 | r32 | Sporting Kansas CitySporting Kans | 0 - 2 | Austin FCAustin FC |
| 31 Jul 22 | r32 | FC DallasFC Dallas | 1 - 0 | L.A. GalaxyL.A. Galaxy |
| |
| 31 Jul 22 | r31 | San Jose EarthquakesSan Jose Eart | 2 - 2 | Real Salt LakeReal Salt Lak |
| |
| 31 Jul 22 | r32 | DC UnitedDC United | 2 - 1 | Orlando CityOrlando City |
| |
| 02 Aug 22 | r31 | New York Red BullsNew York Red | 4 - 5 | Colorado RapidsColorado Rapi |
| |
| 03 Aug 22 | r32 | Seattle Sounders FCSeattle Sound | 1 - 0 | FC DallasFC Dallas |
| 04 Aug 22 | r32 | Charlotte FCCharlotte FC | 3 - 0 | DC UnitedDC United |
| |
| 04 Aug 22 | r33 | Columbus CrewColumbus Crew | 1 - 2 | CF MontréalCF Montréal |
| 04 Aug 22 | r33 | Portland TimbersPortland Timb | 1 - 1 | Nashville SCNashville SC |
| 04 Aug 22 | r33 | San Jose EarthquakesSan Jose Eart | 0 - 1 | Inter MiamiInter Miami |
| 06 Aug 22 | r33 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Houston DynamoHouston Dynam |
| 06 Aug 22 | r33 | Atlanta UnitedAtlanta Unite | 2 - 1 | Seattle Sounders FCSeattle Sound |
| 07 Aug 22 | r33 | Charlotte FCCharlotte FC | 2 - 3 | Chicago FireChicago Fire |
| 07 Aug 22 | r33 | FC CincinnatiFC Cincinnati | 3 - 1 | Philadelphia UnionPhiladelphia |
| 07 Aug 22 | r33 | Columbus CrewColumbus Crew | 3 - 2 | New York CityNew York City |
| 07 Aug 22 | r33 | DC UnitedDC United | 0 - 0 | New York Red BullsNew York Red |
| |
| 07 Aug 22 | r34 | CF MontréalCF Montréal | 2 - 2 | Inter MiamiInter Miami |
| 07 Aug 22 | r34 | Orlando CityOrlando City | 0 - 3 | New England Rev.New England R |
| 07 Aug 22 | r34 | Nashville SCNashville SC | 3 - 4 | Toronto FCToronto FC |
| 07 Aug 22 | r34 | Sporting Kansas CitySporting Kans | 4 - 2 | L.A. GalaxyL.A. Galaxy |
| 07 Aug 22 | r34 | Austin FCAustin FC | 3 - 3 | San Jose EarthquakesSan Jose Eart |
| 07 Aug 22 | r34 | Colorado RapidsColorado Rapi | 4 - 3 | Minnesota UnitedMinnesota Uni |
| 07 Aug 22 | r34 | Real Salt LakeReal Salt Lak | 1 - 4 | Los Angeles FCLos Angeles F |
| 07 Aug 22 | r34 | Portland TimbersPortland Timb | 1 - 1 | FC DallasFC Dallas |
| 13 Aug 22 | r34 | New York Red BullsNew York Red | 0 - 1 | Orlando CityOrlando City |
| 14 Aug 22 | r34 | FC CincinnatiFC Cincinnati | 2 - 2 | Atlanta UnitedAtlanta Unite |
| |
| 14 Aug 22 | r35 | New England Rev.New England R | 1 - 0 | DC UnitedDC United |
| 14 Aug 22 | r35 | Philadelphia UnionPhiladelphia | 4 - 1 | Chicago FireChicago Fire |
| 14 Aug 22 | r35 | Toronto FCToronto FC | 3 - 1 | Portland TimbersPortland Timb |
| 14 Aug 22 | r35 | Inter MiamiInter Miami | 3 - 2 | New York CityNew York City |
| 14 Aug 22 | r35 | Austin FCAustin FC | 4 - 3 | Sporting Kansas CitySporting Kans |
| 14 Aug 22 | r35 | Colorado RapidsColorado Rapi | 1 - 1 | Columbus CrewColumbus Crew |
| 14 Aug 22 | r35 | FC DallasFC Dallas | 4 - 1 | San Jose EarthquakesSan Jose Eart |
| 14 Aug 22 | r35 | Houston DynamoHouston Dynam | 2 - 3 | CF MontréalCF Montréal |
| 14 Aug 22 | r35 | L.A. GalaxyL.A. Galaxy | 5 - 2 | Vancouver WhitecapsVancouver Whi |
| 14 Aug 22 | r35 | Los Angeles FCLos Angeles F | 5 - 0 | Charlotte FCCharlotte FC |
| |
| 15 Aug 22 | r36 | Nashville SCNashville SC | 1 - 2 | Minnesota UnitedMinnesota Uni |
| 15 Aug 22 | r36 | Seattle Sounders FCSeattle Sound | 1 - 2 | Real Salt LakeReal Salt Lak |
| 17 Aug 22 | r36 | Los Angeles FCLos Angeles F | 1 - 0 | DC UnitedDC United |
| 18 Aug 22 | r36 | New York CityNew York City | 1 - 3 | Charlotte FCCharlotte FC |
| 18 Aug 22 | r36 | Atlanta UnitedAtlanta Unite | 1 - 2 | New York Red BullsNew York Red |
| 18 Aug 22 | r36 | Toronto FCToronto FC | 2 - 2 | New England Rev.New England R |
| 18 Aug 22 | r36 | FC DallasFC Dallas | 1 - 0 | Philadelphia UnionPhiladelphia |
| 18 Aug 22 | r36 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Colorado RapidsColorado Rapi |
| 20 Aug 22 | r36 | L.A. GalaxyL.A. Galaxy | 3 - 3 | Seattle Sounders FCSeattle Sound |
| 20 Aug 22 | r36 | New York Red BullsNew York Red | 1 - 1 | FC CincinnatiFC Cincinnati |
| |
| 21 Aug 22 | r37 | DC UnitedDC United | 0 - 6 | Philadelphia UnionPhiladelphia |
| 21 Aug 22 | r37 | CF MontréalCF Montréal | 4 - 0 | New England Rev.New England R |
| 21 Aug 22 | r37 | Minnesota UnitedMinnesota Uni | 2 - 1 | Austin FCAustin FC |
| 21 Aug 22 | r37 | Inter MiamiInter Miami | 2 - 1 | Toronto FCToronto FC |
| 21 Aug 22 | r37 | Colorado RapidsColorado Rapi | 1 - 1 | Houston DynamoHouston Dynam |
| 21 Aug 22 | r37 | Real Salt LakeReal Salt Lak | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 21 Aug 22 | r37 | San Jose EarthquakesSan Jose Eart | 2 - 1 | Los Angeles FCLos Angeles F |
| 21 Aug 22 | r37 | Chicago FireChicago Fire | 0 - 2 | New York CityNew York City |
| 22 Aug 22 | r37 | Charlotte FCCharlotte FC | 1 - 2 | Orlando CityOrlando City |
| |
| 22 Aug 22 | r38 | Sporting Kansas CitySporting Kans | 4 - 1 | Portland TimbersPortland Timb |
| 22 Aug 22 | r38 | Nashville SCNashville SC | 4 - 0 | FC DallasFC Dallas |
| |
| 22 Aug 22 | r37 | Columbus CrewColumbus Crew | 2 - 2 | Atlanta UnitedAtlanta Unite |
| |
| 27 Aug 22 | r38 | Austin FCAustin FC | 4 - 1 | Los Angeles FCLos Angeles F |
| 27 Aug 22 | r38 | Portland TimbersPortland Timb | 2 - 1 | Seattle Sounders FCSeattle Sound |
| 27 Aug 22 | r38 | Minnesota UnitedMinnesota Uni | 2 - 1 | Houston DynamoHouston Dynam |
| 27 Aug 22 | r38 | New York Red BullsNew York Red | 3 - 1 | Inter MiamiInter Miami |
| |
| 28 Aug 22 | r39 | Charlotte FCCharlotte FC | 0 - 2 | Toronto FCToronto FC |
| |
| 28 Aug 22 | r38 | FC CincinnatiFC Cincinnati | 2 - 2 | Columbus CrewColumbus Crew |
| 28 Aug 22 | r38 | Philadelphia UnionPhiladelphia | 6 - 0 | Colorado RapidsColorado Rapi |
| |
| 28 Aug 22 | r39 | Chicago FireChicago Fire | 0 - 2 | CF MontréalCF Montréal |
| |
| 28 Aug 22 | r38 | Sporting Kansas CitySporting Kans | 1 - 0 | San Jose EarthquakesSan Jose Eart |
| 28 Aug 22 | r38 | FC DallasFC Dallas | 1 - 1 | Real Salt LakeReal Salt Lak |
| |
| 28 Aug 22 | r39 | Vancouver WhitecapsVancouver Whi | 0 - 3 | Nashville SCNashville SC |
| 28 Aug 22 | r39 | Atlanta UnitedAtlanta Unite | 3 - 2 | DC UnitedDC United |
| 29 Aug 22 | r39 | Orlando CityOrlando City | 2 - 1 | New York CityNew York City |
| 29 Aug 22 | r39 | New England Rev.New England R | 1 - 2 | L.A. GalaxyL.A. Galaxy |
| |
| 01 Sep 22 | r08 | New York CityNew York City | 1 - 2 | DC UnitedDC United |
| |
| 01 Sep 22 | r40 | Philadelphia UnionPhiladelphia | 4 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 01 Sep 22 | r39 | Columbus CrewColumbus Crew | 1 - 0 | Inter MiamiInter Miami |
| 01 Sep 22 | r39 | CF MontréalCF Montréal | 0 - 1 | New York Red BullsNew York Red |
| 01 Sep 22 | r39 | New England Rev.New England R | 0 - 0 | Chicago FireChicago Fire |
| 01 Sep 22 | r39 | Orlando CityOrlando City | 3 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 01 Sep 22 | r40 | Toronto FCToronto FC | 2 - 2 | L.A. GalaxyL.A. Galaxy |
| 01 Sep 22 | r40 | Houston DynamoHouston Dynam | 2 - 1 | Los Angeles FCLos Angeles F |
| 01 Sep 22 | r40 | Nashville SCNashville SC | 4 - 1 | Colorado RapidsColorado Rapi |
| 01 Sep 22 | r40 | Austin FCAustin FC | 1 - 2 | Portland TimbersPortland Timb |
| 01 Sep 22 | r40 | Real Salt LakeReal Salt Lak | 3 - 0 | Minnesota UnitedMinnesota Uni |
| 03 Sep 22 | r40 | Minnesota UnitedMinnesota Uni | 0 - 3 | FC DallasFC Dallas |
| 03 Sep 22 | r40 | Columbus CrewColumbus Crew | 0 - 0 | Chicago FireChicago Fire |
| 03 Sep 22 | r40 | New York Red BullsNew York Red | 0 - 2 | Philadelphia UnionPhiladelphia |
| 04 Sep 22 | r40 | FC CincinnatiFC Cincinnati | 2 - 0 | Charlotte FCCharlotte FC |
| |
| 04 Sep 22 | r41 | Nashville SCNashville SC | 3 - 0 | Austin FCAustin FC |
| 04 Sep 22 | r41 | Portland TimbersPortland Timb | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 05 Sep 22 | r41 | DC UnitedDC United | 0 - 0 | Colorado RapidsColorado Rapi |
| 05 Sep 22 | r41 | Toronto FCToronto FC | 3 - 4 | CF MontréalCF Montréal |
| 05 Sep 22 | r41 | New England Rev.New England R | 3 - 0 | New York CityNew York City |
| 05 Sep 22 | r41 | L.A. GalaxyL.A. Galaxy | 2 - 2 | Sporting Kansas CitySporting Kans |
| 05 Sep 22 | r41 | Seattle Sounders FCSeattle Sound | 2 - 1 | Houston DynamoHouston Dynam |
| 05 Sep 22 | r41 | San Jose EarthquakesSan Jose Eart | 2 - 0 | Vancouver WhitecapsVancouver Whi |
| 05 Sep 22 | r41 | Los Angeles FCLos Angeles F | 2 - 0 | Real Salt LakeReal Salt Lak |
| |
| 08 Sep 22 | r42 | New York CityNew York City | 1 - 1 | FC CincinnatiFC Cincinnati |
| 10 Sep 22 | r42 | CF MontréalCF Montréal | 2 - 2 | Columbus CrewColumbus Crew |
| 10 Sep 22 | r42 | Charlotte FCCharlotte FC | 1 - 0 | New York CityNew York City |
| 10 Sep 22 | r42 | Nashville SCNashville SC | 1 - 1 | L.A. GalaxyL.A. Galaxy |
| 10 Sep 22 | r42 | New York Red BullsNew York Red | 2 - 1 | New England Rev.New England R |
| 11 Sep 22 | r42 | Atlanta UnitedAtlanta Unite | 4 - 2 | Toronto FCToronto FC |
| 11 Sep 22 | r42 | FC CincinnatiFC Cincinnati | 6 - 0 | San Jose EarthquakesSan Jose Eart |
| 11 Sep 22 | r42 | Philadelphia UnionPhiladelphia | 5 - 1 | Orlando CityOrlando City |
| 11 Sep 22 | r42 | Chicago FireChicago Fire | 3 - 1 | Inter MiamiInter Miami |
| 11 Sep 22 | r42 | Seattle Sounders FCSeattle Sound | 3 - 0 | Austin FCAustin FC |
| |
| 11 Sep 22 | r43 | FC DallasFC Dallas | 2 - 1 | Los Angeles FCLos Angeles F |
| 11 Sep 22 | r43 | Houston DynamoHouston Dynam | 0 - 0 | Sporting Kansas CitySporting Kans |
| 11 Sep 22 | r43 | Colorado RapidsColorado Rapi | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| 11 Sep 22 | r43 | Real Salt LakeReal Salt Lak | 0 - 0 | DC UnitedDC United |
| 11 Sep 22 | r43 | Portland TimbersPortland Timb | 1 - 0 | Minnesota UnitedMinnesota Uni |
| 14 Sep 22 | r43 | CF MontréalCF Montréal | 3 - 2 | Chicago FireChicago Fire |
| 14 Sep 22 | r43 | Inter MiamiInter Miami | 2 - 1 | Columbus CrewColumbus Crew |
| 14 Sep 22 | r43 | Minnesota UnitedMinnesota Uni | 1 - 1 | Los Angeles FCLos Angeles F |
| 14 Sep 22 | r43 | Houston DynamoHouston Dynam | 3 - 1 | New England Rev.New England R |
| |
| 14 Sep 22 | r44 | Sporting Kansas CitySporting Kans | 3 - 0 | DC UnitedDC United |
| 14 Sep 22 | r44 | Orlando CityOrlando City | 0 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 15 Sep 22 | r43 | Austin FCAustin FC | 3 - 0 | Real Salt LakeReal Salt Lak |
| |
| 15 Sep 22 | r44 | Colorado RapidsColorado Rapi | 2 - 1 | San Jose EarthquakesSan Jose Eart |
| 15 Sep 22 | r44 | Vancouver WhitecapsVancouver Whi | 3 - 0 | L.A. GalaxyL.A. Galaxy |
| 17 Sep 22 | r44 | New York CityNew York City | 2 - 0 | New York Red BullsNew York Red |
| 17 Sep 22 | r44 | Atlanta UnitedAtlanta Unite | 0 - 0 | Philadelphia UnionPhiladelphia |
| 18 Sep 22 | r44 | New England Rev.New England R | 0 - 1 | CF MontréalCF Montréal |
| 18 Sep 22 | r44 | Orlando CityOrlando City | 4 - 0 | Toronto FCToronto FC |
| 18 Sep 22 | r44 | Chicago FireChicago Fire | 2 - 3 | Charlotte FCCharlotte FC |
| |
| 18 Sep 22 | r45 | Sporting Kansas CitySporting Kans | 4 - 1 | Minnesota UnitedMinnesota Uni |
| 18 Sep 22 | r45 | Austin FCAustin FC | 1 - 1 | Nashville SCNashville SC |
| 18 Sep 22 | r45 | Real Salt LakeReal Salt Lak | 1 - 2 | FC CincinnatiFC Cincinnati |
| 18 Sep 22 | r45 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Seattle Sounders FCSeattle Sound |
| |
| 18 Sep 22 | r44 | San Jose EarthquakesSan Jose Eart | 1 - 1 | FC DallasFC Dallas |
| |
| 18 Sep 22 | r45 | L.A. GalaxyL.A. Galaxy | 4 - 1 | Colorado RapidsColorado Rapi |
| 18 Sep 22 | r45 | Columbus CrewColumbus Crew | 1 - 1 | Portland TimbersPortland Timb |
| 18 Sep 22 | r45 | DC UnitedDC United | 2 - 3 | Inter MiamiInter Miami |
| 19 Sep 22 | r45 | Los Angeles FCLos Angeles F | 3 - 1 | Houston DynamoHouston Dynam |
| |
| 25 Sep 22 | r23 | San Jose EarthquakesSan Jose Eart | 2 - 3 | L.A. GalaxyL.A. Galaxy |
| |
| 28 Sep 22 | r09 | Seattle Sounders FCSeattle Sound | 1 - 1 | FC CincinnatiFC Cincinnati |
| |
| 01 Oct 22 | r45 | Toronto FCToronto FC | 0 - 1 | Inter MiamiInter Miami |
| |
| 01 Oct 22 | r46 | New England Rev.New England R | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 01 Oct 22 | r46 | Colorado RapidsColorado Rapi | 1 - 0 | FC DallasFC Dallas |
| 01 Oct 22 | r46 | Charlotte FCCharlotte FC | 4 - 0 | Philadelphia UnionPhiladelphia |
| 02 Oct 22 | r46 | FC CincinnatiFC Cincinnati | 2 - 3 | Chicago FireChicago Fire |
| 02 Oct 22 | r46 | Columbus CrewColumbus Crew | 2 - 1 | New York Red BullsNew York Red |
| 02 Oct 22 | r46 | CF MontréalCF Montréal | 1 - 0 | DC UnitedDC United |
| |
| 02 Oct 22 | r45 | San Jose EarthquakesSan Jose Eart | 2 - 0 | Minnesota UnitedMinnesota Uni |
| |
| 02 Oct 22 | r46 | Vancouver WhitecapsVancouver Whi | 2 - 0 | Austin FCAustin FC |
| 02 Oct 22 | r46 | L.A. GalaxyL.A. Galaxy | 1 - 1 | Real Salt LakeReal Salt Lak |
| 02 Oct 22 | r46 | New York CityNew York City | 2 - 1 | Orlando CityOrlando City |
| 02 Oct 22 | r46 | Portland TimbersPortland Timb | 1 - 2 | Los Angeles FCLos Angeles F |
| |
| 02 Oct 22 | r47 | Sporting Kansas CitySporting Kans | 1 - 0 | Seattle Sounders FCSeattle Sound |
| 03 Oct 22 | r47 | Nashville SCNashville SC | 1 - 2 | Houston DynamoHouston Dynam |
| |
| 06 Oct 22 | r31 | Charlotte FCCharlotte FC | 2 - 2 | Columbus CrewColumbus Crew |
| |
| 06 Oct 22 | r41 | Inter MiamiInter Miami | 4 - 1 | Orlando CityOrlando City |
| |
| 09 Oct 22 | r47 | New York Red BullsNew York Red | 2 - 0 | Charlotte FCCharlotte FC |
| 09 Oct 22 | r47 | Atlanta UnitedAtlanta Unite | 1 - 2 | New York CityNew York City |
| 09 Oct 22 | r47 | Chicago FireChicago Fire | 1 - 1 | New England Rev.New England R |
| 09 Oct 22 | r47 | DC UnitedDC United | 2 - 5 | FC CincinnatiFC Cincinnati |
| 09 Oct 22 | r47 | Inter MiamiInter Miami | 1 - 3 | CF MontréalCF Montréal |
| 09 Oct 22 | r47 | Orlando CityOrlando City | 2 - 1 | Columbus CrewColumbus Crew |
| 09 Oct 22 | r47 | Philadelphia UnionPhiladelphia | 4 - 0 | Toronto FCToronto FC |
| 09 Oct 22 | r47 | Austin FCAustin FC | 1 - 1 | Colorado RapidsColorado Rapi |
| |
| 09 Oct 22 | r48 | FC DallasFC Dallas | 2 - 1 | Sporting Kansas CitySporting Kans |
| 09 Oct 22 | r48 | Houston DynamoHouston Dynam | 1 - 3 | L.A. GalaxyL.A. Galaxy |
| 09 Oct 22 | r48 | Los Angeles FCLos Angeles F | 0 - 1 | Nashville SCNashville SC |
| 09 Oct 22 | r48 | Minnesota UnitedMinnesota Uni | 2 - 0 | Vancouver WhitecapsVancouver Whi |
| 09 Oct 22 | r48 | Real Salt LakeReal Salt Lak | 3 - 1 | Portland TimbersPortland Timb |
| 09 Oct 22 | r48 | Seattle Sounders FCSeattle Sound | 2 - 2 | San Jose EarthquakesSan Jose Eart |
| |
| 15 Oct 22 | r01 | New York Red BullsNew York Red | 1 - 2 | FC CincinnatiFC Cincinnati |
| 15 Oct 22 | r01 | L.A. GalaxyL.A. Galaxy | 1 - 0 | Nashville SCNashville SC |
| 16 Oct 22 | r01 | Austin FCAustin FC | 2 - 2 | Real Salt LakeReal Salt Lak |
| 17 Oct 22 | r01 | CF MontréalCF Montréal | 2 - 0 | Orlando CityOrlando City |
| 18 Oct 22 | r01 | New York CityNew York City | 3 - 0 | Inter MiamiInter Miami |
| 18 Oct 22 | r01 | FC DallasFC Dallas | 1 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 21 Oct 22 | QF | Philadelphia UnionPhiladelphia | 1 - 0 | FC CincinnatiFC Cincinnati |
| 21 Oct 22 | QF | Los Angeles FCLos Angeles F | 3 - 2 | L.A. GalaxyL.A. Galaxy |
| 23 Oct 22 | QF | CF MontréalCF Montréal | 1 - 3 | New York CityNew York City |
| 24 Oct 22 | QF | Austin FCAustin FC | 2 - 1 | FC DallasFC Dallas |
| |
| 30 Oct 22 | SF | Los Angeles FCLos Angeles F | 3 - 0 | Austin FCAustin FC |
| 31 Oct 22 | SF | Philadelphia UnionPhiladelphia | 3 - 1 | New York CityNew York City |
| |
| 05 Nov 22 | Final | Los Angeles FCLos Angeles F | 3 - 3 | Philadelphia UnionPhiladelphia |
Team 2022 Schedules
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Columbus Crew
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Inter Miami
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Nashville SC
New England Revolution
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New York Red Bulls
Orlando City
Philadelphia Union
Portland Timbers
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