

Team 2021 Scheduals| 18 Apr |
r01 | Nashville SCNashville SC | 2 - 2 | FC CincinnatiFC Cincinnati |
| 24 Apr |
r03 ![]() | Nashville SCNashville SC | 2 - 2 | CF MontréalCF Montréal |
| 02 May |
r04 | Nashville SCNashville SC | 0 - 0 | Inter MiamiInter Miami |
| 08 May |
r05 | Nashville SCNashville SC | 2 - 0 | New England Rev.New England R |
| 16 May |
r07 | Real Salt LakeReal Salt Lak | 0 - 0 | Nashville SCNashville SC |
| 24 May |
r09 | Nashville SCNashville SC | 1 - 0 | Austin FCAustin FC |
| 29 May |
r10 | Atlanta UnitedAtlanta Unite | 2 - 2 | Nashville SCNashville SC |
| 19 Jun |
r10 | New York Red BullsNew York Red | 2 - 0 | Nashville SCNashville SC |
| 24 Jun |
r13 | Nashville SCNashville SC | 3 - 2 | Toronto FCToronto FC |
| 27 Jun |
r13 ![]() | Nashville SCNashville SC | 1 - 1 | CF MontréalCF Montréal |
| 04 Jul |
r15 | Nashville SCNashville SC | 1 - 0 | Philadelphia UnionPhiladelphia |
| 09 Jul |
r17 | Nashville SCNashville SC | 2 - 2 | Atlanta UnitedAtlanta Unite |
| 18 Jul |
r17 | Nashville SCNashville SC | 5 - 1 | Chicago FireChicago Fire |
| 21 Jul |
r18 | Columbus CrewColumbus Crew | 0 - 0 | Nashville SCNashville SC |
| 25 Jul |
r20 ![]() | Nashville SCNashville SC | 3 - 0 | FC CincinnatiFC Cincinnati |
| 01 Aug |
r22 ![]() | Toronto FCToronto FC | 1 - 1 | Nashville SCNashville SC |
| 04 Aug |
r22 | New England Rev.New England R | 0 - 0 | Nashville SCNashville SC |
| 08 Aug |
r23 | Inter MiamiInter Miami | 2 - 1 | Nashville SCNashville SC |
| 15 Aug |
r26 | Nashville SCNashville SC | 5 - 2 | DC UnitedDC United |
| 19 Aug |
r27 | Nashville SCNashville SC | 1 - 1 | Orlando CityOrlando City |
| 28 Aug |
r29 | Atlanta UnitedAtlanta Unite | 0 - 2 | Nashville SCNashville SC |
| 03 Sep |
r30 | Nashville SCNashville SC | 3 - 1 | New York CityNew York City |
| 12 Sep |
r30 | CF MontréalCF Montréal | 0 - 1 | Nashville SCNashville SC |
| 18 Sep |
r34 | Toronto FCToronto FC | 2 - 1 | Nashville SCNashville SC |
| 22 Sep |
r34 | Inter MiamiInter Miami | 1 - 5 | Nashville SCNashville SC |
| 26 Sep |
r36 | Chicago FireChicago Fire | 0 - 0 | Nashville SCNashville SC |
| 30 Sep |
r37 | Nashville SCNashville SC | 2 - 2 | Orlando CityOrlando City |
| 03 Oct |
r38 | New York CityNew York City | 0 - 0 | Nashville SCNashville SC |
| 16 Oct |
r39 | DC UnitedDC United | 0 - 0 | Nashville SCNashville SC |
| 21 Oct |
r41 | Nashville SCNashville SC | 1 - 1 | Columbus CrewColumbus Crew |
| 23 Oct |
r42 | Philadelphia UnionPhiladelphia | 1 - 0 | Nashville SCNashville SC |
| 27 Oct |
r43 ![]() | FC CincinnatiFC Cincinnati | 3 - 6 | Nashville SCNashville SC |
| 31 Oct |
r44 | Orlando CityOrlando City | 1 - 1 | Nashville SCNashville SC |
| 07 Nov |
r45 | Nashville SCNashville SC | 1 - 1 | New York Red BullsNew York Red |
| 24 Nov |
Playoff | Nashville SCNashville SC | 3 - 1 | Orlando CityOrlando City |
| 28 Nov |
QF | Philadelphia UnionPhiladelphia | 1 - 1 | Nashville SCNashville SC |