

Team 2021 Scheduals| 18 Apr |
r01 | DC UnitedDC United | 2 - 1 | New York CityNew York City |
| 24 Apr |
r02 | New York CityNew York City | 5 - 0 | FC CincinnatiFC Cincinnati |
| 01 May |
r04 | Philadelphia UnionPhiladelphia | 0 - 2 | New York CityNew York City |
| 09 May |
r05 | Orlando CityOrlando City | 1 - 1 | New York CityNew York City |
| 15 May |
r06 | New York CityNew York City | 1 - 1 | Toronto FCToronto FC |
| 23 May |
r08 | New York CityNew York City | 1 - 2 | Columbus CrewColumbus Crew |
| 29 May |
r10 | Los Angeles FCLos Angeles F | 1 - 2 | New York CityNew York City |
| 19 Jun |
r11 | New York CityNew York City | 2 - 3 | New England Rev.New England R |
| 23 Jun |
r12 | New York CityNew York City | 1 - 0 | Atlanta UnitedAtlanta Unite |
| 27 Jun |
r14 | New York CityNew York City | 2 - 1 | DC UnitedDC United |
| 07 Jul |
r16 ![]() | CF MontréalCF Montréal | 2 - 1 | New York CityNew York City |
| 17 Jul |
r17 | Columbus CrewColumbus Crew | 2 - 1 | New York CityNew York City |
| 21 Jul |
r18 ![]() | New York CityNew York City | 1 - 0 | CF MontréalCF Montréal |
| 25 Jul |
r20 ![]() | New York CityNew York City | 5 - 0 | Orlando CityOrlando City |
| 30 Jul |
r21 ![]() | New York CityNew York City | 4 - 1 | Columbus CrewColumbus Crew |
| 05 Aug |
r23 | Chicago FireChicago Fire | 0 - 0 | New York CityNew York City |
| 08 Aug |
r24 | Toronto FCToronto FC | 2 - 2 | New York CityNew York City |
| 15 Aug |
r25 | New York CityNew York City | 2 - 0 | Inter MiamiInter Miami |
| 18 Aug |
r26 | Philadelphia UnionPhiladelphia | 1 - 0 | New York CityNew York City |
| 28 Aug |
r29 | New York CityNew York City | 2 - 0 | New England Rev.New England R |
| 03 Sep |
r30 | Nashville SCNashville SC | 3 - 1 | New York CityNew York City |
| 11 Sep |
r31 | New England Rev.New England R | 2 - 1 | New York CityNew York City |
| 14 Sep |
r32 | New York CityNew York City | 3 - 3 | FC DallasFC Dallas |
| 18 Sep |
r33 | FC CincinnatiFC Cincinnati | 1 - 2 | New York CityNew York City |
| 23 Sep |
r28 | New York Red BullsNew York Red | 1 - 1 | New York CityNew York City |
| 26 Sep |
r35 | New York CityNew York City | 0 - 1 | New York Red BullsNew York Red |
| 30 Sep |
r36 | Chicago FireChicago Fire | 2 - 0 | New York CityNew York City |
| 03 Oct |
r38 | New York CityNew York City | 0 - 0 | Nashville SCNashville SC |
| 17 Oct |
r40 | New York Red BullsNew York Red | 1 - 0 | New York CityNew York City |
| 20 Oct |
r40 | Atlanta UnitedAtlanta Unite | 1 - 1 | New York CityNew York City |
| 23 Oct |
r41 | New York CityNew York City | 6 - 0 | DC UnitedDC United |
| 27 Oct |
r43 | New York CityNew York City | 1 - 0 | Chicago FireChicago Fire |
| 30 Oct |
r44 | Inter MiamiInter Miami | 1 - 3 | New York CityNew York City |
| 07 Nov |
r46 | New York CityNew York City | 1 - 1 | Philadelphia UnionPhiladelphia |
| 21 Nov |
Playoff | New York CityNew York City | 2 - 0 | Atlanta UnitedAtlanta Unite |
| 01 Dec |
QF | New England Rev.New England R | 2 - 2 | New York CityNew York City |
| 05 Dec |
SF | Philadelphia UnionPhiladelphia | 1 - 2 | New York CityNew York City |
| 11 Dec |
Final | Portland TimbersPortland Timb | 1 - 1 | New York CityNew York City |