

Team 2021 Scheduals| 19 Apr |
r02 | Vancouver WhitecapsVancouver Whi | 1 - 0 | Portland TimbersPortland Timb |
| 24 Apr |
r02 | Toronto FCToronto FC | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 03 May |
r04 | Vancouver WhitecapsVancouver Whi | 0 - 1 | Colorado RapidsColorado Rapi |
| 08 May |
r06 ![]() | Vancouver WhitecapsVancouver Whi | 2 - 0 | CF MontréalCF Montréal |
| 13 May |
r06 ![]() | Minnesota UnitedMinnesota Uni | 1 - 0 | Vancouver WhitecapsVancouver Whi |
| 16 May |
r07 | Sporting Kansas CitySporting Kans | 3 - 0 | Vancouver WhitecapsVancouver Whi |
| 23 May |
r08 | Houston DynamoHouston Dynam | 2 - 1 | Vancouver WhitecapsVancouver Whi |
| 19 Jun |
r10 | Real Salt LakeReal Salt Lak | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| 24 Jun |
r13 | Vancouver WhitecapsVancouver Whi | 1 - 2 | L.A. GalaxyL.A. Galaxy |
| 27 Jun |
r14 | Seattle Sounders FCSeattle Sound | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 05 Jul |
r15 | FC DallasFC Dallas | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 08 Jul |
r16 | Vancouver WhitecapsVancouver Whi | 0 - 4 | Real Salt LakeReal Salt Lak |
| 18 Jul |
r18 | Vancouver WhitecapsVancouver Whi | 2 - 1 | L.A. GalaxyL.A. Galaxy |
| 21 Jul |
r19 | Vancouver WhitecapsVancouver Whi | 0 - 0 | Houston DynamoHouston Dynam |
| 25 Jul |
r20 ![]() | Los Angeles FCLos Angeles F | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 01 Aug |
r22 ![]() | Vancouver WhitecapsVancouver Whi | 2 - 2 | Minnesota UnitedMinnesota Uni |
| 09 Aug |
r24 | L.A. GalaxyL.A. Galaxy | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 14 Aug |
r25 | San Jose EarthquakesSan Jose Eart | 0 - 0 | Vancouver WhitecapsVancouver Whi |
| 19 Aug |
r27 | Austin FCAustin FC | 1 - 2 | Vancouver WhitecapsVancouver Whi |
| 22 Aug |
r28 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Los Angeles FCLos Angeles F |
| 30 Aug |
r30 | Vancouver WhitecapsVancouver Whi | 4 - 1 | Real Salt LakeReal Salt Lak |
| 04 Sep |
r21 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Austin FCAustin FC |
| 11 Sep |
r31 | Vancouver WhitecapsVancouver Whi | 0 - 1 | Portland TimbersPortland Timb |
| 20 Sep |
r34 | Colorado RapidsColorado Rapi | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 26 Sep |
r35 | Vancouver WhitecapsVancouver Whi | 1 - 0 | FC DallasFC Dallas |
| 30 Sep |
r37 | Houston DynamoHouston Dynam | 0 - 0 | Vancouver WhitecapsVancouver Whi |
| 03 Oct |
r38 | Vancouver WhitecapsVancouver Whi | 3 - 0 | San Jose EarthquakesSan Jose Eart |
| 10 Oct |
r33 | Seattle Sounders FCSeattle Sound | 4 - 1 | Vancouver WhitecapsVancouver Whi |
| 18 Oct |
r40 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Sporting Kansas CitySporting Kans |
| 21 Oct |
r41 | Portland TimbersPortland Timb | 2 - 3 | Vancouver WhitecapsVancouver Whi |
| 24 Oct |
r42 | San Jose EarthquakesSan Jose Eart | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 28 Oct |
r43 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Minnesota UnitedMinnesota Uni |
| 03 Nov |
r45 ![]() | Los Angeles FCLos Angeles F | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 07 Nov |
r46 | Vancouver WhitecapsVancouver Whi | 1 - 1 | Seattle Sounders FCSeattle Sound |
| 20 Nov |
Playoff | Sporting Kansas CitySporting Kans | 3 - 1 | Vancouver WhitecapsVancouver Whi |