

Team 2021 Scheduals| 18 Apr |
r01 | DC UnitedDC United | 2 - 1 | New York CityNew York City |
| 25 Apr |
r02 | New England Rev.New England R | 1 - 0 | DC UnitedDC United |
| 02 May |
r04 | San Jose EarthquakesSan Jose Eart | 4 - 1 | DC UnitedDC United |
| 08 May |
r05 | Columbus CrewColumbus Crew | 3 - 1 | DC UnitedDC United |
| 14 May |
r06 | DC UnitedDC United | 1 - 0 | Chicago FireChicago Fire |
| 17 May |
r08 | DC UnitedDC United | 0 - 1 | Orlando CityOrlando City |
| 24 May |
r09 | DC UnitedDC United | 0 - 1 | Philadelphia UnionPhiladelphia |
| 30 May |
r09 | Inter MiamiInter Miami | 0 - 3 | DC UnitedDC United |
| 20 Jun |
r11 | DC UnitedDC United | 1 - 0 | Inter MiamiInter Miami |
| 24 Jun |
r11 ![]() | CF MontréalCF Montréal | 0 - 0 | DC UnitedDC United |
| 27 Jun |
r14 | New York CityNew York City | 2 - 1 | DC UnitedDC United |
| 03 Jul |
r14 | DC UnitedDC United | 7 - 1 | Toronto FCToronto FC |
| 17 Jul |
r17 ![]() | Philadelphia UnionPhiladelphia | 2 - 1 | DC UnitedDC United |
| 22 Jul |
r18 | Chicago FireChicago Fire | 2 - 2 | DC UnitedDC United |
| 26 Jul |
r20 ![]() | DC UnitedDC United | 1 - 0 | New York Red BullsNew York Red |
| 31 Jul |
r21 ![]() | FC CincinnatiFC Cincinnati | 0 - 0 | DC UnitedDC United |
| 04 Aug |
r22 | Columbus CrewColumbus Crew | 2 - 4 | DC UnitedDC United |
| 09 Aug |
r23 | DC UnitedDC United | 2 - 1 | CF MontréalCF Montréal |
| 15 Aug |
r26 | Nashville SCNashville SC | 5 - 2 | DC UnitedDC United |
| 18 Aug |
r26 | New England Rev.New England R | 3 - 2 | DC UnitedDC United |
| 22 Aug |
r28 | DC UnitedDC United | 1 - 2 | Atlanta UnitedAtlanta Unite |
| 29 Aug |
r29 | DC UnitedDC United | 3 - 1 | Philadelphia UnionPhiladelphia |
| 11 Sep |
r31 | New York Red BullsNew York Red | 1 - 1 | DC UnitedDC United |
| 15 Sep |
r32 | DC UnitedDC United | 3 - 0 | Chicago FireChicago Fire |
| 18 Sep |
r33 | Atlanta UnitedAtlanta Unite | 3 - 2 | DC UnitedDC United |
| 25 Sep |
r35 | DC UnitedDC United | 4 - 2 | FC CincinnatiFC Cincinnati |
| 29 Sep |
r36 | DC UnitedDC United | 3 - 1 | Minnesota UnitedMinnesota Uni |
| 02 Oct |
r38 | Orlando CityOrlando City | 2 - 1 | DC UnitedDC United |
| 16 Oct |
r39 | DC UnitedDC United | 0 - 0 | Nashville SCNashville SC |
| 20 Oct |
r40 | DC UnitedDC United | 2 - 3 | New England Rev.New England R |
| 23 Oct |
r41 | New York CityNew York City | 6 - 0 | DC UnitedDC United |
| 27 Oct |
r43 | DC UnitedDC United | 1 - 0 | New York Red BullsNew York Red |
| 31 Oct |
r44 | DC UnitedDC United | 1 - 3 | Columbus CrewColumbus Crew |
| 07 Nov |
r46 | Toronto FCToronto FC | 1 - 3 | DC UnitedDC United |