| 17 Apr 21 | r01      | Houston DynamoHouston Dynam | 2 - 1 | San Jose EarthquakesSan Jose Eart |
| 17 Apr 21 | r01 | Seattle Sounders FCSeattle Sound | 4 - 0 | Minnesota UnitedMinnesota Uni |
| 17 Apr 21 | r01 | CF MontréalCF Montréal | 4 - 2 | Toronto FCToronto FC |
| 17 Apr 21 | r01 | Orlando CityOrlando City | 0 - 0 | Atlanta UnitedAtlanta Unite |
| 18 Apr 21 | r01 | New York Red BullsNew York Red | 1 - 2 | Sporting Kansas CitySporting Kans |
| 18 Apr 21 | r01 | FC DallasFC Dallas | 0 - 0 | Colorado RapidsColorado Rapi |
| 18 Apr 21 | r01 | DC UnitedDC United | 2 - 1 | New York CityNew York City |
| 18 Apr 21 | r01 | Nashville SCNashville SC | 2 - 2 | FC CincinnatiFC Cincinnati |
| 18 Apr 21 | r01 | Chicago FireChicago Fire | 2 - 2 | New England Rev.New England R |
| |
| 18 Apr 21 | r02 | Inter MiamiInter Miami | 2 - 3 | L.A. GalaxyL.A. Galaxy |
| 18 Apr 21 | r02 | Columbus CrewColumbus Crew | 0 - 0 | Philadelphia UnionPhiladelphia |
| |
| 18 Apr 21 | r01 | Los Angeles FCLos Angeles F | 2 - 0 | Austin FCAustin FC |
| |
| 19 Apr 21 | r02 | Vancouver WhitecapsVancouver Whi | 1 - 0 | Portland TimbersPortland Timb |
| 24 Apr 21 | r02 | Sporting Kansas CitySporting Kans | 1 - 1 | Orlando CityOrlando City |
| 24 Apr 21 | r02 | New York CityNew York City | 5 - 0 | FC CincinnatiFC Cincinnati |
| |
| 24 Apr 21 | r03 | Nashville SCNashville SC | 2 - 2 | CF MontréalCF Montréal |
| |
| 24 Apr 21 | r02 | Toronto FCToronto FC | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 24 Apr 21 | r02 | San Jose EarthquakesSan Jose Eart | 3 - 1 | FC DallasFC Dallas |
| 25 Apr 21 | r02 | Atlanta UnitedAtlanta Unite | 3 - 1 | Chicago FireChicago Fire |
| 25 Apr 21 | r02 | Minnesota UnitedMinnesota Uni | 1 - 2 | Real Salt LakeReal Salt Lak |
| 25 Apr 21 | r02 | New England Rev.New England R | 1 - 0 | DC UnitedDC United |
| |
| 25 Apr 21 | r03 | Philadelphia UnionPhiladelphia | 1 - 2 | Inter MiamiInter Miami |
| 25 Apr 21 | r03 | Colorado RapidsColorado Rapi | 1 - 3 | Austin FCAustin FC |
| 25 Apr 21 | r03 | Portland TimbersPortland Timb | 2 - 1 | Houston DynamoHouston Dynam |
| 25 Apr 21 | r03 | L.A. GalaxyL.A. Galaxy | 3 - 2 | New York Red BullsNew York Red |
| |
| 25 Apr 21 | r02 | Los Angeles FCLos Angeles F | 1 - 1 | Seattle Sounders FCSeattle Sound |
| |
| 01 May 21 | r03 | New York Red BullsNew York Red | 2 - 0 | Chicago FireChicago Fire |
| 01 May 21 | r03 | Real Salt LakeReal Salt Lak | 3 - 1 | Sporting Kansas CitySporting Kans |
| |
| 01 May 21 | r04 | CF MontréalCF Montréal | 0 - 0 | Columbus CrewColumbus Crew |
| |
| 01 May 21 | r03 | Houston DynamoHouston Dynam | 1 - 1 | Los Angeles FCLos Angeles F |
| |
| 02 May 21 | r04 | New England Rev.New England R | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 02 May 21 | r04 | Orlando CityOrlando City | 3 - 0 | FC CincinnatiFC Cincinnati |
| 02 May 21 | r04 | Philadelphia UnionPhiladelphia | 0 - 2 | New York CityNew York City |
| 02 May 21 | r04 | FC DallasFC Dallas | 4 - 1 | Portland TimbersPortland Timb |
| 02 May 21 | r04 | Minnesota UnitedMinnesota Uni | 0 - 1 | Austin FCAustin FC |
| 02 May 21 | r04 | San Jose EarthquakesSan Jose Eart | 4 - 1 | DC UnitedDC United |
| 02 May 21 | r04 | Nashville SCNashville SC | 0 - 0 | Inter MiamiInter Miami |
| 03 May 21 | r04 | Seattle Sounders FCSeattle Sound | 3 - 0 | L.A. GalaxyL.A. Galaxy |
| 03 May 21 | r04 | Vancouver WhitecapsVancouver Whi | 0 - 1 | Colorado RapidsColorado Rapi |
| 08 May 21 | r04 | Real Salt LakeReal Salt Lak | 1 - 2 | San Jose EarthquakesSan Jose Eart |
| |
| 08 May 21 | r05 | New York Red BullsNew York Red | 2 - 0 | Toronto FCToronto FC |
| 08 May 21 | r05 | Chicago FireChicago Fire | 0 - 2 | Philadelphia UnionPhiladelphia |
| 08 May 21 | r05 | Nashville SCNashville SC | 2 - 0 | New England Rev.New England R |
| 08 May 21 | r05 | Columbus CrewColumbus Crew | 3 - 1 | DC UnitedDC United |
| |
| 08 May 21 | r06 | Vancouver WhitecapsVancouver Whi | 2 - 0 | CF MontréalCF Montréal |
| |
| 08 May 21 | r05 | FC DallasFC Dallas | 1 - 1 | Houston DynamoHouston Dynam |
| 09 May 21 | r05 | L.A. GalaxyL.A. Galaxy | 2 - 1 | Los Angeles FCLos Angeles F |
| 09 May 21 | r05 | Colorado RapidsColorado Rapi | 3 - 2 | Minnesota UnitedMinnesota Uni |
| 09 May 21 | r05 | Inter MiamiInter Miami | 1 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 09 May 21 | r06 | Portland TimbersPortland Timb | 1 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 09 May 21 | r05 | Orlando CityOrlando City | 1 - 1 | New York CityNew York City |
| |
| 11 May 21 | r06 | Sporting Kansas CitySporting Kans | 2 - 1 | Austin FCAustin FC |
| 13 May 21 | r06 | Toronto FCToronto FC | 2 - 0 | Columbus CrewColumbus Crew |
| 13 May 21 | r06 | Houston DynamoHouston Dynam | 1 - 0 | Sporting Kansas CitySporting Kans |
| 13 May 21 | r06 | Minnesota UnitedMinnesota Uni | 1 - 0 | Vancouver WhitecapsVancouver Whi |
| 13 May 21 | r06 | San Jose EarthquakesSan Jose Eart | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 14 May 21 | r06 | Philadelphia UnionPhiladelphia | 1 - 1 | New England Rev.New England R |
| 14 May 21 | r06 | Inter MiamiInter Miami | 0 - 2 | CF MontréalCF Montréal |
| 14 May 21 | r06 | DC UnitedDC United | 1 - 0 | Chicago FireChicago Fire |
| 15 May 21 | r06 | New York CityNew York City | 1 - 1 | Toronto FCToronto FC |
| |
| 15 May 21 | r07 | L.A. GalaxyL.A. Galaxy | 2 - 0 | Austin FCAustin FC |
| 16 May 21 | r07 | Atlanta UnitedAtlanta Unite | 1 - 0 | CF MontréalCF Montréal |
| 16 May 21 | r07 | Minnesota UnitedMinnesota Uni | 1 - 0 | FC DallasFC Dallas |
| 16 May 21 | r07 | Colorado RapidsColorado Rapi | 3 - 1 | Houston DynamoHouston Dynam |
| 16 May 21 | r07 | Real Salt LakeReal Salt Lak | 0 - 0 | Nashville SCNashville SC |
| 16 May 21 | r07 | San Jose EarthquakesSan Jose Eart | 0 - 2 | Portland TimbersPortland Timb |
| 16 May 21 | r07 | Sporting Kansas CitySporting Kans | 3 - 0 | Vancouver WhitecapsVancouver Whi |
| |
| 16 May 21 | r03 | FC CincinnatiFC Cincinnati | 2 - 3 | Inter MiamiInter Miami |
| |
| 17 May 21 | r07 | Philadelphia UnionPhiladelphia | 1 - 0 | New York Red BullsNew York Red |
| |
| 17 May 21 | r08 | DC UnitedDC United | 0 - 1 | Orlando CityOrlando City |
| 17 May 21 | r08 | Seattle Sounders FCSeattle Sound | 2 - 0 | Los Angeles FCLos Angeles F |
| |
| 17 May 21 | r07 | New England Rev.New England R | 1 - 0 | Columbus CrewColumbus Crew |
| |
| 22 May 21 | r08 | CF MontréalCF Montréal | 1 - 2 | FC CincinnatiFC Cincinnati |
| |
| 22 May 21 | r09 | Portland TimbersPortland Timb | 3 - 0 | L.A. GalaxyL.A. Galaxy |
| 22 May 21 | r09 | Chicago FireChicago Fire | 1 - 0 | Inter MiamiInter Miami |
| |
| 23 May 21 | r08 | Orlando CityOrlando City | 1 - 0 | Toronto FCToronto FC |
| 23 May 21 | r08 | FC DallasFC Dallas | 2 - 2 | Real Salt LakeReal Salt Lak |
| 23 May 21 | r08 | New England Rev.New England R | 3 - 1 | New York Red BullsNew York Red |
| 23 May 21 | r08 | Houston DynamoHouston Dynam | 2 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 23 May 21 | r09 | San Jose EarthquakesSan Jose Eart | 1 - 3 | Sporting Kansas CitySporting Kans |
| 23 May 21 | r09 | Los Angeles FCLos Angeles F | 2 - 1 | Colorado RapidsColorado Rapi |
| 23 May 21 | r09 | Seattle Sounders FCSeattle Sound | 1 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 23 May 21 | r08 | New York CityNew York City | 1 - 2 | Columbus CrewColumbus Crew |
| |
| 24 May 21 | r09 | Nashville SCNashville SC | 1 - 0 | Austin FCAustin FC |
| 25 May 21 | r09 | DC UnitedDC United | 0 - 1 | Philadelphia UnionPhiladelphia |
| 29 May 21 | r09 | New York Red BullsNew York Red | 2 - 1 | Orlando CityOrlando City |
| |
| 29 May 21 | r10 | Chicago FireChicago Fire | 0 - 1 | CF MontréalCF Montréal |
| |
| 29 May 21 | r09 | FC CincinnatiFC Cincinnati | 0 - 1 | New England Rev.New England R |
| 29 May 21 | r09 | Columbus CrewColumbus Crew | 2 - 1 | Toronto FCToronto FC |
| |
| 29 May 21 | r10 | Atlanta UnitedAtlanta Unite | 2 - 2 | Nashville SCNashville SC |
| 29 May 21 | r10 | Los Angeles FCLos Angeles F | 1 - 2 | New York CityNew York City |
| 30 May 21 | r10 | L.A. GalaxyL.A. Galaxy | 1 - 0 | San Jose EarthquakesSan Jose Eart |
| |
| 30 May 21 | r09 | Inter MiamiInter Miami | 0 - 3 | DC UnitedDC United |
| |
| 30 May 21 | r10 | Sporting Kansas CitySporting Kans | 3 - 2 | Houston DynamoHouston Dynam |
| 30 May 21 | r10 | Colorado RapidsColorado Rapi | 3 - 0 | FC DallasFC Dallas |
| 30 May 21 | r10 | Real Salt LakeReal Salt Lak | 1 - 1 | Minnesota UnitedMinnesota Uni |
| 31 May 21 | r10 | Philadelphia UnionPhiladelphia | 3 - 0 | Portland TimbersPortland Timb |
| 31 May 21 | r10 | Seattle Sounders FCSeattle Sound | 0 - 0 | Austin FCAustin FC |
| |
| 12 Jun 21 | r17 | Sporting Kansas CitySporting Kans | 1 - 1 | Austin FCAustin FC |
| |
| 19 Jun 21 | r10 | New York Red BullsNew York Red | 2 - 0 | Nashville SCNashville SC |
| 19 Jun 21 | r10 | Real Salt LakeReal Salt Lak | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 19 Jun 21 | r11 | New York CityNew York City | 2 - 3 | New England Rev.New England R |
| 20 Jun 21 | r11 | FC CincinnatiFC Cincinnati | 0 - 2 | Colorado RapidsColorado Rapi |
| 20 Jun 21 | r11 | Columbus CrewColumbus Crew | 2 - 0 | Chicago FireChicago Fire |
| 20 Jun 21 | r11 | Toronto FCToronto FC | 2 - 3 | Orlando CityOrlando City |
| 20 Jun 21 | r11 | DC UnitedDC United | 1 - 0 | Inter MiamiInter Miami |
| 20 Jun 21 | r11 | FC DallasFC Dallas | 1 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 20 Jun 21 | r03 | Austin FCAustin FC | 0 - 0 | San Jose EarthquakesSan Jose Eart |
| |
| 20 Jun 21 | r11 | L.A. GalaxyL.A. Galaxy | 1 - 2 | Seattle Sounders FCSeattle Sound |
| 20 Jun 21 | r11 | Portland TimbersPortland Timb | 2 - 1 | Sporting Kansas CitySporting Kans |
| 20 Jun 21 | r11 | Los Angeles FCLos Angeles F | 1 - 1 | Houston DynamoHouston Dynam |
| |
| 20 Jun 21 | r12 | Atlanta UnitedAtlanta Unite | 2 - 2 | Philadelphia UnionPhiladelphia |
| 23 Jun 21 | r12 | Orlando CityOrlando City | 5 - 0 | San Jose EarthquakesSan Jose Eart |
| 23 Jun 21 | r12 | New York CityNew York City | 1 - 0 | Atlanta UnitedAtlanta Unite |
| 24 Jun 21 | r12 | New England Rev.New England R | 3 - 2 | New York Red BullsNew York Red |
| 24 Jun 21 | r12 | Philadelphia UnionPhiladelphia | 1 - 0 | Columbus CrewColumbus Crew |
| 24 Jun 21 | r12 | Minnesota UnitedMinnesota Uni | 2 - 0 | Austin FCAustin FC |
| 24 Jun 21 | r12 | Chicago FireChicago Fire | 0 - 1 | FC CincinnatiFC Cincinnati |
| |
| 24 Jun 21 | r11 | CF MontréalCF Montréal | 0 - 0 | DC UnitedDC United |
| |
| 24 Jun 21 | r12 | Houston DynamoHouston Dynam | 2 - 2 | Portland TimbersPortland Timb |
| 24 Jun 21 | r12 | Sporting Kansas CitySporting Kans | 3 - 1 | Colorado RapidsColorado Rapi |
| |
| 24 Jun 21 | r13 | Nashville SCNashville SC | 3 - 2 | Toronto FCToronto FC |
| 24 Jun 21 | r13 | Seattle Sounders FCSeattle Sound | 2 - 1 | Real Salt LakeReal Salt Lak |
| 24 Jun 21 | r13 | Los Angeles FCLos Angeles F | 2 - 0 | FC DallasFC Dallas |
| 24 Jun 21 | r13 | Vancouver WhitecapsVancouver Whi | 1 - 2 | L.A. GalaxyL.A. Galaxy |
| 26 Jun 21 | r13 | Inter MiamiInter Miami | 1 - 2 | Orlando CityOrlando City |
| 26 Jun 21 | r13 | Sporting Kansas CitySporting Kans | 2 - 1 | Los Angeles FCLos Angeles F |
| 27 Jun 21 | r13 | Toronto FCToronto FC | 0 - 2 | FC CincinnatiFC Cincinnati |
| 27 Jun 21 | r13 | Chicago FireChicago Fire | 3 - 3 | Philadelphia UnionPhiladelphia |
| 27 Jun 21 | r13 | Real Salt LakeReal Salt Lak | 1 - 1 | Houston DynamoHouston Dynam |
| 27 Jun 21 | r13 | Nashville SCNashville SC | 1 - 1 | CF MontréalCF Montréal |
| |
| 27 Jun 21 | r14 | Seattle Sounders FCSeattle Sound | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 27 Jun 21 | r14 | San Jose EarthquakesSan Jose Eart | 1 - 3 | L.A. GalaxyL.A. Galaxy |
| 27 Jun 21 | r14 | Portland TimbersPortland Timb | 0 - 1 | Minnesota UnitedMinnesota Uni |
| 27 Jun 21 | r14 | Atlanta UnitedAtlanta Unite | 0 - 0 | New York Red BullsNew York Red |
| 27 Jun 21 | r14 | New York CityNew York City | 2 - 1 | DC UnitedDC United |
| 28 Jun 21 | r14 | Austin FCAustin FC | 0 - 0 | Columbus CrewColumbus Crew |
| 28 Jun 21 | r14 | FC DallasFC Dallas | 2 - 1 | New England Rev.New England R |
| |
| 02 Jul 21 | r15 | Austin FCAustin FC | 4 - 1 | Portland TimbersPortland Timb |
| |
| 03 Jul 21 | r14 | Columbus CrewColumbus Crew | 2 - 2 | New England Rev.New England R |
| 03 Jul 21 | r14 | DC UnitedDC United | 7 - 1 | Toronto FCToronto FC |
| 03 Jul 21 | r14 | CF MontréalCF Montréal | 1 - 0 | Inter MiamiInter Miami |
| 04 Jul 21 | r14 | Orlando CityOrlando City | 1 - 2 | New York Red BullsNew York Red |
| |
| 04 Jul 21 | r15 | Minnesota UnitedMinnesota Uni | 2 - 2 | San Jose EarthquakesSan Jose Eart |
| 04 Jul 21 | r15 | Chicago FireChicago Fire | 3 - 0 | Atlanta UnitedAtlanta Unite |
| 04 Jul 21 | r15 | Nashville SCNashville SC | 1 - 0 | Philadelphia UnionPhiladelphia |
| 04 Jul 21 | r15 | Houston DynamoHouston Dynam | 1 - 1 | FC CincinnatiFC Cincinnati |
| 04 Jul 21 | r15 | Real Salt LakeReal Salt Lak | 0 - 1 | Los Angeles FCLos Angeles F |
| 05 Jul 21 | r15 | FC DallasFC Dallas | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 05 Jul 21 | r15 | Colorado RapidsColorado Rapi | 1 - 1 | Seattle Sounders FCSeattle Sound |
| 05 Jul 21 | r15 | L.A. GalaxyL.A. Galaxy | 0 - 2 | Sporting Kansas CitySporting Kans |
| |
| 08 Jul 21 | r16 | New England Rev.New England R | 2 - 3 | Toronto FCToronto FC |
| 08 Jul 21 | r16 | CF MontréalCF Montréal | 2 - 1 | New York CityNew York City |
| 08 Jul 21 | r16 | Chicago FireChicago Fire | 3 - 1 | Orlando CityOrlando City |
| 08 Jul 21 | r16 | Austin FCAustin FC | 0 - 2 | Los Angeles FCLos Angeles F |
| 08 Jul 21 | r16 | Colorado RapidsColorado Rapi | 2 - 0 | Minnesota UnitedMinnesota Uni |
| 08 Jul 21 | r16 | Seattle Sounders FCSeattle Sound | 2 - 0 | Houston DynamoHouston Dynam |
| 08 Jul 21 | r16 | Vancouver WhitecapsVancouver Whi | 0 - 4 | Real Salt LakeReal Salt Lak |
| 08 Jul 21 | r16 | L.A. GalaxyL.A. Galaxy | 3 - 1 | FC DallasFC Dallas |
| 09 Jul 21 | r16 | New York Red BullsNew York Red | 1 - 1 | Philadelphia UnionPhiladelphia |
| |
| 09 Jul 21 | r17 | Nashville SCNashville SC | 2 - 2 | Atlanta UnitedAtlanta Unite |
| |
| 10 Jul 21 | r16 | FC CincinnatiFC Cincinnati | 2 - 2 | Columbus CrewColumbus Crew |
| |
| 17 Jul 21 | r17 | Atlanta UnitedAtlanta Unite | 0 - 1 | New England Rev.New England R |
| 18 Jul 21 | r17 | Columbus CrewColumbus Crew | 2 - 1 | New York CityNew York City |
| 18 Jul 21 | r17 | Philadelphia UnionPhiladelphia | 2 - 1 | DC UnitedDC United |
| 18 Jul 21 | r17 | Toronto FCToronto FC | 1 - 1 | Orlando CityOrlando City |
| |
| 18 Jul 21 | r18 | CF MontréalCF Montréal | 5 - 4 | FC CincinnatiFC Cincinnati |
| |
| 18 Jul 21 | r17 | Nashville SCNashville SC | 5 - 1 | Chicago FireChicago Fire |
| 18 Jul 21 | r17 | Colorado RapidsColorado Rapi | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| |
| 18 Jul 21 | r18 | Vancouver WhitecapsVancouver Whi | 2 - 1 | L.A. GalaxyL.A. Galaxy |
| 18 Jul 21 | r18 | Los Angeles FCLos Angeles F | 2 - 1 | Real Salt LakeReal Salt Lak |
| 18 Jul 21 | r18 | Portland TimbersPortland Timb | 1 - 0 | FC DallasFC Dallas |
| 18 Jul 21 | r18 | Minnesota UnitedMinnesota Uni | 1 - 0 | Seattle Sounders FCSeattle Sound |
| |
| 21 Jul 21 | r19 | Vancouver WhitecapsVancouver Whi | 0 - 0 | Houston DynamoHouston Dynam |
| |
| 21 Jul 21 | r18 | New York CityNew York City | 1 - 0 | CF MontréalCF Montréal |
| 22 Jul 21 | r18 | Inter MiamiInter Miami | 0 - 5 | New England Rev.New England R |
| 22 Jul 21 | r18 | Columbus CrewColumbus Crew | 0 - 0 | Nashville SCNashville SC |
| 22 Jul 21 | r18 | Toronto FCToronto FC | 1 - 1 | New York Red BullsNew York Red |
| 22 Jul 21 | r18 | FC CincinnatiFC Cincinnati | 1 - 1 | Atlanta UnitedAtlanta Unite |
| 22 Jul 21 | r18 | Chicago FireChicago Fire | 2 - 2 | DC UnitedDC United |
| |
| 22 Jul 21 | r19 | Sporting Kansas CitySporting Kans | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 22 Jul 21 | r19 | Colorado RapidsColorado Rapi | 2 - 0 | FC DallasFC Dallas |
| |
| 22 Jul 21 | r18 | Real Salt LakeReal Salt Lak | 2 - 2 | L.A. GalaxyL.A. Galaxy |
| |
| 22 Jul 21 | r19 | L.A. GalaxyL.A. Galaxy | 2 - 2 | Real Salt LakeReal Salt Lak |
| 22 Jul 21 | r19 | Portland TimbersPortland Timb | 2 - 1 | Los Angeles FCLos Angeles F |
| 23 Jul 21 | r19 | Orlando CityOrlando City | 2 - 1 | Philadelphia UnionPhiladelphia |
| 23 Jul 21 | r19 | Austin FCAustin FC | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 24 Jul 21 | r19 | Atlanta UnitedAtlanta Unite | 0 - 1 | Columbus CrewColumbus Crew |
| 25 Jul 21 | r19 | Minnesota UnitedMinnesota Uni | 2 - 1 | Portland TimbersPortland Timb |
| |
| 25 Jul 21 | r20 | Chicago FireChicago Fire | 1 - 2 | Toronto FCToronto FC |
| 25 Jul 21 | r20 | FC DallasFC Dallas | 4 - 0 | L.A. GalaxyL.A. Galaxy |
| 25 Jul 21 | r20 | Nashville SCNashville SC | 3 - 0 | FC CincinnatiFC Cincinnati |
| 25 Jul 21 | r20 | San Jose EarthquakesSan Jose Eart | 1 - 1 | Houston DynamoHouston Dynam |
| 25 Jul 21 | r20 | Real Salt LakeReal Salt Lak | 3 - 0 | Colorado RapidsColorado Rapi |
| 25 Jul 21 | r20 | Los Angeles FCLos Angeles F | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 25 Jul 21 | r20 | New York CityNew York City | 5 - 0 | Orlando CityOrlando City |
| |
| 25 Jul 21 | r19 | New England Rev.New England R | 2 - 1 | CF MontréalCF Montréal |
| 26 Jul 21 | r19 | Inter MiamiInter Miami | 1 - 1 | Philadelphia UnionPhiladelphia |
| |
| 26 Jul 21 | r20 | DC UnitedDC United | 1 - 0 | New York Red BullsNew York Red |
| 26 Jul 21 | r20 | Seattle Sounders FCSeattle Sound | 1 - 3 | Sporting Kansas CitySporting Kans |
| |
| 29 Jul 21 | r21 | Los Angeles FCLos Angeles F | 2 - 2 | Minnesota UnitedMinnesota Uni |
| 31 Jul 21 | r21 | New York CityNew York City | 4 - 1 | Columbus CrewColumbus Crew |
| 31 Jul 21 | r21 | Orlando CityOrlando City | 3 - 2 | Atlanta UnitedAtlanta Unite |
| 31 Jul 21 | r21 | L.A. GalaxyL.A. Galaxy | 4 - 1 | Portland TimbersPortland Timb |
| 31 Jul 21 | r21 | New York Red BullsNew York Red | 2 - 3 | New England Rev.New England R |
| 31 Jul 21 | r21 | Seattle Sounders FCSeattle Sound | 0 - 1 | San Jose EarthquakesSan Jose Eart |
| 01 Aug 21 | r21 | FC CincinnatiFC Cincinnati | 0 - 0 | DC UnitedDC United |
| |
| 01 Aug 21 | r20 | Inter MiamiInter Miami | 2 - 1 | CF MontréalCF Montréal |
| |
| 01 Aug 21 | r21 | Houston DynamoHouston Dynam | 0 - 0 | Real Salt LakeReal Salt Lak |
| |
| 01 Aug 21 | r22 | Sporting Kansas CitySporting Kans | 1 - 2 | FC DallasFC Dallas |
| 01 Aug 21 | r22 | Austin FCAustin FC | 0 - 1 | Colorado RapidsColorado Rapi |
| 01 Aug 21 | r22 | Vancouver WhitecapsVancouver Whi | 2 - 2 | Minnesota UnitedMinnesota Uni |
| 01 Aug 21 | r22 | Philadelphia UnionPhiladelphia | 1 - 1 | Chicago FireChicago Fire |
| 02 Aug 21 | r22 | Toronto FCToronto FC | 1 - 1 | Nashville SCNashville SC |
| 05 Aug 21 | r22 | New England Rev.New England R | 0 - 0 | Nashville SCNashville SC |
| |
| 05 Aug 21 | r23 | New York Red BullsNew York Red | 0 - 0 | FC CincinnatiFC Cincinnati |
| |
| 05 Aug 21 | r22 | Columbus CrewColumbus Crew | 2 - 4 | DC UnitedDC United |
| 05 Aug 21 | r22 | Philadelphia UnionPhiladelphia | 3 - 0 | Toronto FCToronto FC |
| |
| 05 Aug 21 | r21 | CF MontréalCF Montréal | 2 - 2 | Atlanta UnitedAtlanta Unite |
| |
| 05 Aug 21 | r22 | Orlando CityOrlando City | 1 - 1 | Inter MiamiInter Miami |
| |
| 05 Aug 21 | r23 | Chicago FireChicago Fire | 0 - 0 | New York CityNew York City |
| 05 Aug 21 | r23 | Austin FCAustin FC | 3 - 2 | Houston DynamoHouston Dynam |
| |
| 05 Aug 21 | r21 | L.A. GalaxyL.A. Galaxy | 1 - 0 | Real Salt LakeReal Salt Lak |
| |
| 05 Aug 21 | r23 | Seattle Sounders FCSeattle Sound | 1 - 1 | FC DallasFC Dallas |
| 05 Aug 21 | r23 | Los Angeles FCLos Angeles F | 1 - 4 | Sporting Kansas CitySporting Kans |
| 05 Aug 21 | r23 | Portland TimbersPortland Timb | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 05 Aug 21 | r23 | Real Salt LakeReal Salt Lak | 1 - 0 | L.A. GalaxyL.A. Galaxy |
| 08 Aug 21 | r23 | FC CincinnatiFC Cincinnati | 1 - 1 | Orlando CityOrlando City |
| |
| 08 Aug 21 | r24 | Columbus CrewColumbus Crew | 2 - 3 | Atlanta UnitedAtlanta Unite |
| 08 Aug 21 | r24 | Minnesota UnitedMinnesota Uni | 2 - 0 | Houston DynamoHouston Dynam |
| 08 Aug 21 | r24 | Toronto FCToronto FC | 2 - 2 | New York CityNew York City |
| 08 Aug 21 | r24 | FC DallasFC Dallas | 2 - 0 | Austin FCAustin FC |
| 08 Aug 21 | r24 | Colorado RapidsColorado Rapi | 0 - 0 | Sporting Kansas CitySporting Kans |
| 08 Aug 21 | r24 | Portland TimbersPortland Timb | 3 - 2 | Real Salt LakeReal Salt Lak |
| |
| 08 Aug 21 | r23 | Inter MiamiInter Miami | 2 - 1 | Nashville SCNashville SC |
| |
| 08 Aug 21 | r24 | Chicago FireChicago Fire | 2 - 1 | New York Red BullsNew York Red |
| 08 Aug 21 | r24 | New England Rev.New England R | 2 - 1 | Philadelphia UnionPhiladelphia |
| 09 Aug 21 | r24 | San Jose EarthquakesSan Jose Eart | 2 - 1 | Los Angeles FCLos Angeles F |
| 09 Aug 21 | r24 | L.A. GalaxyL.A. Galaxy | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 09 Aug 21 | r23 | DC UnitedDC United | 2 - 1 | CF MontréalCF Montréal |
| |
| 14 Aug 21 | r25 | San Jose EarthquakesSan Jose Eart | 0 - 0 | Vancouver WhitecapsVancouver Whi |
| 14 Aug 21 | r25 | Minnesota UnitedMinnesota Uni | 0 - 1 | L.A. GalaxyL.A. Galaxy |
| 15 Aug 21 | r25 | New York CityNew York City | 2 - 0 | Inter MiamiInter Miami |
| 15 Aug 21 | r25 | Toronto FCToronto FC | 1 - 2 | New England Rev.New England R |
| |
| 15 Aug 21 | r24 | CF MontréalCF Montréal | 2 - 1 | New York Red BullsNew York Red |
| |
| 15 Aug 21 | r25 | FC DallasFC Dallas | 0 - 2 | Sporting Kansas CitySporting Kans |
| 15 Aug 21 | r25 | Houston DynamoHouston Dynam | 1 - 3 | Colorado RapidsColorado Rapi |
| |
| 15 Aug 21 | r26 | Real Salt LakeReal Salt Lak | 1 - 0 | Austin FCAustin FC |
| 15 Aug 21 | r26 | Atlanta UnitedAtlanta Unite | 1 - 0 | Los Angeles FCLos Angeles F |
| |
| 15 Aug 21 | r25 | Chicago FireChicago Fire | 1 - 0 | Columbus CrewColumbus Crew |
| |
| 16 Aug 21 | r26 | Nashville SCNashville SC | 5 - 2 | DC UnitedDC United |
| 16 Aug 21 | r26 | Portland TimbersPortland Timb | 2 - 6 | Seattle Sounders FCSeattle Sound |
| 18 Aug 21 | r26 | L.A. GalaxyL.A. Galaxy | 1 - 2 | Colorado RapidsColorado Rapi |
| 18 Aug 21 | r26 | San Jose EarthquakesSan Jose Eart | 1 - 1 | Minnesota UnitedMinnesota Uni |
| 19 Aug 21 | r26 | New England Rev.New England R | 3 - 2 | DC UnitedDC United |
| 19 Aug 21 | r26 | Atlanta UnitedAtlanta Unite | 1 - 0 | Toronto FCToronto FC |
| |
| 19 Aug 21 | r27 | New York Red BullsNew York Red | 1 - 0 | Columbus CrewColumbus Crew |
| |
| 19 Aug 21 | r26 | Inter MiamiInter Miami | 3 - 2 | Chicago FireChicago Fire |
| 19 Aug 21 | r26 | Philadelphia UnionPhiladelphia | 1 - 0 | New York CityNew York City |
| |
| 19 Aug 21 | r25 | FC CincinnatiFC Cincinnati | 0 - 0 | CF MontréalCF Montréal |
| |
| 19 Aug 21 | r27 | FC DallasFC Dallas | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 19 Aug 21 | r27 | Nashville SCNashville SC | 1 - 1 | Orlando CityOrlando City |
| 19 Aug 21 | r27 | Sporting Kansas CitySporting Kans | 1 - 1 | Portland TimbersPortland Timb |
| 19 Aug 21 | r27 | Austin FCAustin FC | 1 - 2 | Vancouver WhitecapsVancouver Whi |
| 19 Aug 21 | r27 | Real Salt LakeReal Salt Lak | 2 - 1 | Houston DynamoHouston Dynam |
| 21 Aug 21 | r27 | L.A. GalaxyL.A. Galaxy | 1 - 2 | San Jose EarthquakesSan Jose Eart |
| 21 Aug 21 | r27 | Minnesota UnitedMinnesota Uni | 0 - 0 | Sporting Kansas CitySporting Kans |
| |
| 21 Aug 21 | r28  | Columbus CrewColumbus Crew | 1 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 22 Aug 21 | r27 | Inter MiamiInter Miami | 3 - 1 | Toronto FCToronto FC |
| |
| 22 Aug 21 | r28 | Orlando CityOrlando City | 1 - 0 | Chicago FireChicago Fire |
| 22 Aug 21 | r28 | DC UnitedDC United | 1 - 2 | Atlanta UnitedAtlanta Unite |
| 22 Aug 21 | r28 | New England Rev.New England R | 4 - 1 | FC CincinnatiFC Cincinnati |
| |
| 22 Aug 21 | r27 | Philadelphia UnionPhiladelphia | 1 - 1 | CF MontréalCF Montréal |
| |
| 22 Aug 21 | r28 | Houston DynamoHouston Dynam | 2 - 2 | FC DallasFC Dallas |
| 22 Aug 21 | r28 | Austin FCAustin FC | 3 - 1 | Portland TimbersPortland Timb |
| 22 Aug 21 | r28 | Colorado RapidsColorado Rapi | 2 - 1 | Real Salt LakeReal Salt Lak |
| 22 Aug 21 | r28 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Los Angeles FCLos Angeles F |
| |
| 27 Aug 21 | r29 | Columbus CrewColumbus Crew | 3 - 2 | FC CincinnatiFC Cincinnati |
| |
| 28 Aug 21 | r27 | CF MontréalCF Montréal | 3 - 1 | Toronto FCToronto FC |
| |
| 28 Aug 21 | r29 | Orlando CityOrlando City | 0 - 0 | Inter MiamiInter Miami |
| 28 Aug 21 | r29 | Atlanta UnitedAtlanta Unite | 0 - 2 | Nashville SCNashville SC |
| 28 Aug 21 | r29 | New York Red BullsNew York Red | 0 - 1 | Chicago FireChicago Fire |
| 29 Aug 21 | r29 | Los Angeles FCLos Angeles F | 3 - 3 | L.A. GalaxyL.A. Galaxy |
| 29 Aug 21 | r29 | New York CityNew York City | 2 - 0 | New England Rev.New England R |
| 29 Aug 21 | r29 | DC UnitedDC United | 3 - 1 | Philadelphia UnionPhiladelphia |
| 29 Aug 21 | r29 | Houston DynamoHouston Dynam | 1 - 2 | Minnesota UnitedMinnesota Uni |
| 29 Aug 21 | r29 | Sporting Kansas CitySporting Kans | 1 - 1 | Colorado RapidsColorado Rapi |
| |
| 30 Aug 21 | r30 | Austin FCAustin FC | 3 - 5 | FC DallasFC Dallas |
| 30 Aug 21 | r30 | Vancouver WhitecapsVancouver Whi | 4 - 1 | Real Salt LakeReal Salt Lak |
| 30 Aug 21 | r30 | Seattle Sounders FCSeattle Sound | 0 - 2 | Portland TimbersPortland Timb |
| 04 Sep 21 | r30 | Nashville SCNashville SC | 3 - 1 | New York CityNew York City |
| |
| 04 Sep 21 | r32 | Philadelphia UnionPhiladelphia | 0 - 1 | New England Rev.New England R |
| |
| 04 Sep 21 | r30 | Houston DynamoHouston Dynam | 0 - 2 | Portland TimbersPortland Timb |
| 04 Sep 21 | r30 | Los Angeles FCLos Angeles F | 4 - 0 | Sporting Kansas CitySporting Kans |
| |
| 05 Sep 21 | r21 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Austin FCAustin FC |
| |
| 05 Sep 21 | r30 | Orlando CityOrlando City | 3 - 2 | Columbus CrewColumbus Crew |
| 05 Sep 21 | r30 | FC CincinnatiFC Cincinnati | 0 - 1 | Inter MiamiInter Miami |
| 05 Sep 21 | r30 | Real Salt LakeReal Salt Lak | 3 - 2 | FC DallasFC Dallas |
| 05 Sep 21 | r30 | San Jose EarthquakesSan Jose Eart | 0 - 1 | Colorado RapidsColorado Rapi |
| |
| 11 Sep 21 | r31 | Atlanta UnitedAtlanta Unite | 3 - 0 | Orlando CityOrlando City |
| 11 Sep 21 | r31 | Vancouver WhitecapsVancouver Whi | 0 - 1 | Portland TimbersPortland Timb |
| 11 Sep 21 | r31 | Colorado RapidsColorado Rapi | 1 - 1 | L.A. GalaxyL.A. Galaxy |
| 11 Sep 21 | r31 | Seattle Sounders FCSeattle Sound | 1 - 0 | Minnesota UnitedMinnesota Uni |
| 11 Sep 21 | r31 | New York Red BullsNew York Red | 1 - 1 | DC UnitedDC United |
| 12 Sep 21 | r31 | New England Rev.New England R | 2 - 1 | New York CityNew York City |
| 12 Sep 21 | r31 | Inter MiamiInter Miami | 1 - 0 | Columbus CrewColumbus Crew |
| 12 Sep 21 | r31 | FC CincinnatiFC Cincinnati | 2 - 0 | Toronto FCToronto FC |
| |
| 12 Sep 21 | r30 | CF MontréalCF Montréal | 0 - 1 | Nashville SCNashville SC |
| |
| 12 Sep 21 | r31 | FC DallasFC Dallas | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 12 Sep 21 | r31 | Houston DynamoHouston Dynam | 3 - 0 | Austin FCAustin FC |
| |
| 12 Sep 21 | r32 | Sporting Kansas CitySporting Kans | 2 - 0 | Chicago FireChicago Fire |
| 13 Sep 21 | r32 | Los Angeles FCLos Angeles F | 3 - 2 | Real Salt LakeReal Salt Lak |
| 14 Sep 21 | r32 | New York CityNew York City | 3 - 3 | FC DallasFC Dallas |
| 15 Sep 21 | r32 | Toronto FCToronto FC | 0 - 1 | Inter MiamiInter Miami |
| 15 Sep 21 | r32 | Columbus CrewColumbus Crew | 2 - 1 | New York Red BullsNew York Red |
| 16 Sep 21 | r32 | Atlanta UnitedAtlanta Unite | 4 - 0 | FC CincinnatiFC Cincinnati |
| 16 Sep 21 | r32 | DC UnitedDC United | 3 - 0 | Chicago FireChicago Fire |
| |
| 16 Sep 21 | r31 | Orlando CityOrlando City | 2 - 4 | CF MontréalCF Montréal |
| |
| 16 Sep 21 | r33 | Sporting Kansas CitySporting Kans | 4 - 0 | Minnesota UnitedMinnesota Uni |
| 16 Sep 21 | r33 | Austin FCAustin FC | 1 - 2 | Los Angeles FCLos Angeles F |
| 16 Sep 21 | r33 | Portland TimbersPortland Timb | 2 - 2 | Colorado RapidsColorado Rapi |
| 16 Sep 21 | r33 | L.A. GalaxyL.A. Galaxy | 1 - 1 | Houston DynamoHouston Dynam |
| 16 Sep 21 | r33 | San Jose EarthquakesSan Jose Eart | 3 - 4 | Real Salt LakeReal Salt Lak |
| 18 Sep 21 | r33 | Inter MiamiInter Miami | 0 - 4 | New York Red BullsNew York Red |
| 18 Sep 21 | r33 | Atlanta UnitedAtlanta Unite | 3 - 2 | DC UnitedDC United |
| 19 Sep 21 | r33 | New England Rev.New England R | 1 - 1 | Columbus CrewColumbus Crew |
| 19 Sep 21 | r33 | FC CincinnatiFC Cincinnati | 1 - 2 | New York CityNew York City |
| |
| 19 Sep 21 | r34 | Toronto FCToronto FC | 2 - 1 | Nashville SCNashville SC |
| 19 Sep 21 | r34 | Minnesota UnitedMinnesota Uni | 3 - 0 | L.A. GalaxyL.A. Galaxy |
| 19 Sep 21 | r34 | Austin FCAustin FC | 3 - 4 | San Jose EarthquakesSan Jose Eart |
| 19 Sep 21 | r34 | Houston DynamoHouston Dynam | 3 - 2 | FC DallasFC Dallas |
| 19 Sep 21 | r34 | Real Salt LakeReal Salt Lak | 1 - 0 | Seattle Sounders FCSeattle Sound |
| |
| 19 Sep 21 | r33 | CF MontréalCF Montréal | 2 - 0 | Chicago FireChicago Fire |
| |
| 19 Sep 21 | r34 | Philadelphia UnionPhiladelphia | 3 - 1 | Orlando CityOrlando City |
| 20 Sep 21 | r34 | Portland TimbersPortland Timb | 2 - 1 | Los Angeles FCLos Angeles F |
| 20 Sep 21 | r34 | Colorado RapidsColorado Rapi | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 23 Sep 21 | r28 | New York Red BullsNew York Red | 1 - 1 | New York CityNew York City |
| |
| 23 Sep 21 | r34 | Inter MiamiInter Miami | 1 - 5 | Nashville SCNashville SC |
| |
| 23 Sep 21 | r44 | Chicago FireChicago Fire | 2 - 3 | New England Rev.New England R |
| |
| 25 Sep 21 | r35 | Philadelphia UnionPhiladelphia | 1 - 0 | Atlanta UnitedAtlanta Unite |
| 26 Sep 21 | r35 | New England Rev.New England R | 2 - 1 | Orlando CityOrlando City |
| 26 Sep 21 | r35 | DC UnitedDC United | 4 - 2 | FC CincinnatiFC Cincinnati |
| |
| 26 Sep 21 | r34 | Columbus CrewColumbus Crew | 2 - 1 | CF MontréalCF Montréal |
| |
| 26 Sep 21 | r35 | New York CityNew York City | 0 - 1 | New York Red BullsNew York Red |
| 26 Sep 21 | r35 | Minnesota UnitedMinnesota Uni | 2 - 0 | Houston DynamoHouston Dynam |
| 26 Sep 21 | r35 | Colorado RapidsColorado Rapi | 0 - 0 | Toronto FCToronto FC |
| 26 Sep 21 | r35 | San Jose EarthquakesSan Jose Eart | 2 - 0 | Los Angeles FCLos Angeles F |
| 26 Sep 21 | r35 | Vancouver WhitecapsVancouver Whi | 1 - 0 | FC DallasFC Dallas |
| |
| 26 Sep 21 | r36 | Portland TimbersPortland Timb | 6 - 1 | Real Salt LakeReal Salt Lak |
| 26 Sep 21 | r36 | Chicago FireChicago Fire | 0 - 0 | Nashville SCNashville SC |
| 27 Sep 21 | r36 | Sporting Kansas CitySporting Kans | 1 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 27 Sep 21 | r35 | Austin FCAustin FC | 2 - 0 | L.A. GalaxyL.A. Galaxy |
| |
| 29 Sep 21 | r36 | New York Red BullsNew York Red | 1 - 1 | Philadelphia UnionPhiladelphia |
| 30 Sep 21 | r36 | Toronto FCToronto FC | 3 - 2 | FC CincinnatiFC Cincinnati |
| 30 Sep 21 | r36 | Atlanta UnitedAtlanta Unite | 1 - 0 | Inter MiamiInter Miami |
| 30 Sep 21 | r36 | DC UnitedDC United | 3 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 30 Sep 21 | r35 | CF MontréalCF Montréal | 1 - 4 | New England Rev.New England R |
| |
| 30 Sep 21 | r36 | FC DallasFC Dallas | 1 - 3 | Sporting Kansas CitySporting Kans |
| 30 Sep 21 | r36 | Chicago FireChicago Fire | 2 - 0 | New York CityNew York City |
| |
| 30 Sep 21 | r37 | Nashville SCNashville SC | 2 - 2 | Orlando CityOrlando City |
| 30 Sep 21 | r37 | Colorado RapidsColorado Rapi | 3 - 0 | Austin FCAustin FC |
| 30 Sep 21 | r37 | Houston DynamoHouston Dynam | 0 - 0 | Vancouver WhitecapsVancouver Whi |
| 30 Sep 21 | r37 | Real Salt LakeReal Salt Lak | 2 - 1 | L.A. GalaxyL.A. Galaxy |
| 30 Sep 21 | r37 | Los Angeles FCLos Angeles F | 1 - 2 | Portland TimbersPortland Timb |
| 30 Sep 21 | r37 | San Jose EarthquakesSan Jose Eart | 1 - 3 | Seattle Sounders FCSeattle Sound |
| 02 Oct 21 | r37 | Austin FCAustin FC | 2 - 1 | Real Salt LakeReal Salt Lak |
| |
| 03 Oct 21 | r36 | CF MontréalCF Montréal | 2 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 03 Oct 21 | r38 | FC CincinnatiFC Cincinnati | 0 - 1 | New York Red BullsNew York Red |
| 03 Oct 21 | r38 | Orlando CityOrlando City | 2 - 1 | DC UnitedDC United |
| 03 Oct 21 | r38 | FC DallasFC Dallas | 0 - 0 | Minnesota UnitedMinnesota Uni |
| 03 Oct 21 | r38 | Vancouver WhitecapsVancouver Whi | 3 - 0 | San Jose EarthquakesSan Jose Eart |
| 03 Oct 21 | r38 | New York CityNew York City | 0 - 0 | Nashville SCNashville SC |
| 03 Oct 21 | r38 | Philadelphia UnionPhiladelphia | 3 - 0 | Columbus CrewColumbus Crew |
| |
| 03 Oct 21 | r37 | Sporting Kansas CitySporting Kans | 4 - 2 | Houston DynamoHouston Dynam |
| |
| 03 Oct 21 | r38 | Toronto FCToronto FC | 3 - 1 | Chicago FireChicago Fire |
| |
| 03 Oct 21 | r37 | Portland TimbersPortland Timb | 1 - 0 | Inter MiamiInter Miami |
| |
| 04 Oct 21 | r38 | L.A. GalaxyL.A. Galaxy | 1 - 1 | Los Angeles FCLos Angeles F |
| 04 Oct 21 | r38 | Seattle Sounders FCSeattle Sound | 3 - 0 | Colorado RapidsColorado Rapi |
| |
| 09 Oct 21 | r17 | New York Red BullsNew York Red | 1 - 0 | Inter MiamiInter Miami |
| |
| 10 Oct 21 | r25 | FC CincinnatiFC Cincinnati | 1 - 2 | Philadelphia UnionPhiladelphia |
| |
| 10 Oct 21 | r33 | Seattle Sounders FCSeattle Sound | 4 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 10 Oct 21 | r23 | Minnesota UnitedMinnesota Uni | 1 - 3 | Colorado RapidsColorado Rapi |
| |
| 16 Oct 21 | r38 | CF MontréalCF Montréal | 2 - 2 | Philadelphia UnionPhiladelphia |
| |
| 16 Oct 21 | r39 | Los Angeles FCLos Angeles F | 3 - 1 | San Jose EarthquakesSan Jose Eart |
| 16 Oct 21 | r39 | Columbus CrewColumbus Crew | 4 - 0 | Inter MiamiInter Miami |
| 17 Oct 21 | r39 | New England Rev.New England R | 2 - 2 | Chicago FireChicago Fire |
| 17 Oct 21 | r39 | FC CincinnatiFC Cincinnati | 0 - 1 | Orlando CityOrlando City |
| 17 Oct 21 | r39 | DC UnitedDC United | 0 - 0 | Nashville SCNashville SC |
| 17 Oct 21 | r39 | Toronto FCToronto FC | 0 - 2 | Atlanta UnitedAtlanta Unite |
| 17 Oct 21 | r39 | Houston DynamoHouston Dynam | 2 - 1 | Seattle Sounders FCSeattle Sound |
| 17 Oct 21 | r39 | Austin FCAustin FC | 0 - 1 | Minnesota UnitedMinnesota Uni |
| 17 Oct 21 | r39 | Real Salt LakeReal Salt Lak | 3 - 1 | Colorado RapidsColorado Rapi |
| 17 Oct 21 | r39 | L.A. GalaxyL.A. Galaxy | 2 - 1 | Portland TimbersPortland Timb |
| |
| 17 Oct 21 | r40 | New York Red BullsNew York Red | 1 - 0 | New York CityNew York City |
| 18 Oct 21 | r40 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Sporting Kansas CitySporting Kans |
| 21 Oct 21 | r40 | Inter MiamiInter Miami | 3 - 0 | Toronto FCToronto FC |
| 21 Oct 21 | r40 | FC CincinnatiFC Cincinnati | 3 - 4 | Chicago FireChicago Fire |
| 21 Oct 21 | r40 | Atlanta UnitedAtlanta Unite | 1 - 1 | New York CityNew York City |
| 21 Oct 21 | r40 | DC UnitedDC United | 2 - 3 | New England Rev.New England R |
| |
| 21 Oct 21 | r39 | Orlando CityOrlando City | 1 - 1 | CF MontréalCF Montréal |
| |
| 21 Oct 21 | r40 | FC DallasFC Dallas | 2 - 3 | Los Angeles FCLos Angeles F |
| 21 Oct 21 | r40 | Minnesota UnitedMinnesota Uni | 3 - 2 | Philadelphia UnionPhiladelphia |
| 21 Oct 21 | r40 | Houston DynamoHouston Dynam | 0 - 3 | L.A. GalaxyL.A. Galaxy |
| |
| 21 Oct 21 | r41 | Nashville SCNashville SC | 1 - 1 | Columbus CrewColumbus Crew |
| 21 Oct 21 | r41 | Colorado RapidsColorado Rapi | 1 - 1 | Seattle Sounders FCSeattle Sound |
| 21 Oct 21 | r41 | Portland TimbersPortland Timb | 2 - 3 | Vancouver WhitecapsVancouver Whi |
| 21 Oct 21 | r41 | San Jose EarthquakesSan Jose Eart | 4 - 0 | Austin FCAustin FC |
| |
| 23 Oct 21 | r42 | Seattle Sounders FCSeattle Sound | 1 - 2 | Sporting Kansas CitySporting Kans |
| |
| 23 Oct 21 | r41 | Columbus CrewColumbus Crew | 1 - 2 | New York Red BullsNew York Red |
| 24 Oct 21 | r41 | New York CityNew York City | 6 - 0 | DC UnitedDC United |
| |
| 24 Oct 21 | r42 | Philadelphia UnionPhiladelphia | 1 - 0 | Nashville SCNashville SC |
| |
| 24 Oct 21 | r40 | Toronto FCToronto FC | 1 - 1 | CF MontréalCF Montréal |
| |
| 24 Oct 21 | r41 | Inter MiamiInter Miami | 5 - 1 | FC CincinnatiFC Cincinnati |
| |
| 24 Oct 21 | r42 | Minnesota UnitedMinnesota Uni | 1 - 1 | Los Angeles FCLos Angeles F |
| 24 Oct 21 | r42 | Chicago FireChicago Fire | 1 - 0 | Real Salt LakeReal Salt Lak |
| 24 Oct 21 | r42 | Colorado RapidsColorado Rapi | 2 - 0 | Portland TimbersPortland Timb |
| |
| 24 Oct 21 | r41 | L.A. GalaxyL.A. Galaxy | 2 - 2 | FC DallasFC Dallas |
| |
| 24 Oct 21 | r42 | San Jose EarthquakesSan Jose Eart | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 24 Oct 21 | r42 | Austin FCAustin FC | 2 - 1 | Houston DynamoHouston Dynam |
| |
| 25 Oct 21 | r41 | Orlando CityOrlando City | 2 - 2 | New England Rev.New England R |
| |
| 27 Oct 21 | r42 | Los Angeles FCLos Angeles F | 3 - 0 | Seattle Sounders FCSeattle Sound |
| 28 Oct 21 | r42 | New England Rev.New England R | 1 - 0 | Colorado RapidsColorado Rapi |
| 28 Oct 21 | r42 | Atlanta UnitedAtlanta Unite | 2 - 1 | Inter MiamiInter Miami |
| |
| 28 Oct 21 | r43 | FC CincinnatiFC Cincinnati | 3 - 6 | Nashville SCNashville SC |
| 28 Oct 21 | r43 | New York CityNew York City | 1 - 0 | Chicago FireChicago Fire |
| 28 Oct 21 | r43 | Columbus CrewColumbus Crew | 3 - 2 | Orlando CityOrlando City |
| 28 Oct 21 | r43 | Toronto FCToronto FC | 2 - 2 | Philadelphia UnionPhiladelphia |
| 28 Oct 21 | r43 | DC UnitedDC United | 1 - 0 | New York Red BullsNew York Red |
| 28 Oct 21 | r43 | FC DallasFC Dallas | 1 - 2 | Real Salt LakeReal Salt Lak |
| 28 Oct 21 | r43 | Sporting Kansas CitySporting Kans | 2 - 0 | L.A. GalaxyL.A. Galaxy |
| 28 Oct 21 | r43 | Portland TimbersPortland Timb | 2 - 0 | San Jose EarthquakesSan Jose Eart |
| 28 Oct 21 | r43 | Vancouver WhitecapsVancouver Whi | 2 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 30 Oct 21 | r44 | Inter MiamiInter Miami | 1 - 3 | New York CityNew York City |
| |
| 30 Oct 21 | r43 | New York Red BullsNew York Red | 1 - 0 | CF MontréalCF Montréal |
| |
| 30 Oct 21 | r44 | Real Salt LakeReal Salt Lak | 3 - 4 | San Jose EarthquakesSan Jose Eart |
| 31 Oct 21 | r44 | Atlanta UnitedAtlanta Unite | 1 - 1 | Toronto FCToronto FC |
| 31 Oct 21 | r44 | FC DallasFC Dallas | 2 - 1 | Austin FCAustin FC |
| 31 Oct 21 | r44 | DC UnitedDC United | 1 - 3 | Columbus CrewColumbus Crew |
| 31 Oct 21 | r44 | Minnesota UnitedMinnesota Uni | 2 - 1 | Sporting Kansas CitySporting Kans |
| 31 Oct 21 | r44 | Houston DynamoHouston Dynam | 0 - 1 | Colorado RapidsColorado Rapi |
| 31 Oct 21 | r44 | Orlando CityOrlando City | 1 - 1 | Nashville SCNashville SC |
| 31 Oct 21 | r44 | Philadelphia UnionPhiladelphia | 2 - 0 | FC CincinnatiFC Cincinnati |
| |
| 02 Nov 21 | r45 | Seattle Sounders FCSeattle Sound | 1 - 1 | L.A. GalaxyL.A. Galaxy |
| 03 Nov 21 | r45 | Los Angeles FCLos Angeles F | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 03 Nov 21 | r45 | New York Red BullsNew York Red | 0 - 0 | Atlanta UnitedAtlanta Unite |
| |
| 03 Nov 21 | r44 | CF MontréalCF Montréal | 2 - 0 | Houston DynamoHouston Dynam |
| |
| 04 Nov 21 | r45 | Austin FCAustin FC | 3 - 1 | Sporting Kansas CitySporting Kans |
| 04 Nov 21 | r45 | Real Salt LakeReal Salt Lak | 1 - 3 | Portland TimbersPortland Timb |
| 07 Nov 21 | r45 | FC CincinnatiFC Cincinnati | 1 - 2 | Atlanta UnitedAtlanta Unite |
| 07 Nov 21 | r45 | Columbus CrewColumbus Crew | 2 - 0 | Chicago FireChicago Fire |
| 07 Nov 21 | r45 | Nashville SCNashville SC | 1 - 1 | New York Red BullsNew York Red |
| 07 Nov 21 | r45 | New England Rev.New England R | 0 - 1 | Inter MiamiInter Miami |
| |
| 07 Nov 21 | r46 | New York CityNew York City | 1 - 1 | Philadelphia UnionPhiladelphia |
| 07 Nov 21 | r46 | Toronto FCToronto FC | 1 - 3 | DC UnitedDC United |
| |
| 07 Nov 21 | r45 | CF MontréalCF Montréal | 0 - 2 | Orlando CityOrlando City |
| |
| 07 Nov 21 | r46 | Colorado RapidsColorado Rapi | 5 - 2 | Los Angeles FCLos Angeles F |
| 07 Nov 21 | r46 | L.A. GalaxyL.A. Galaxy | 3 - 3 | Minnesota UnitedMinnesota Uni |
| 07 Nov 21 | r46 | Portland TimbersPortland Timb | 3 - 0 | Austin FCAustin FC |
| 07 Nov 21 | r46 | San Jose EarthquakesSan Jose Eart | 1 - 1 | FC DallasFC Dallas |
| 07 Nov 21 | r46 | Sporting Kansas CitySporting Kans | 0 - 1 | Real Salt LakeReal Salt Lak |
| 07 Nov 21 | r46 | Vancouver WhitecapsVancouver Whi | 1 - 1 | Seattle Sounders FCSeattle Sound |
| |
| 20 Nov 21 | Playoff | Philadelphia UnionPhiladelphia | 1 - 0 | New York Red BullsNew York Red |
| 20 Nov 21 | Playoff | Sporting Kansas CitySporting Kans | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| 21 Nov 21 | Playoff | New York CityNew York City | 2 - 0 | Atlanta UnitedAtlanta Unite |
| 21 Nov 21 | Playoff | Portland TimbersPortland Timb | 3 - 1 | Minnesota UnitedMinnesota Uni |
| 24 Nov 21 | Playoff | Nashville SCNashville SC | 3 - 1 | Orlando CityOrlando City |
| 24 Nov 21 | Playoff | Seattle Sounders FCSeattle Sound | 0 - 0 | Real Salt LakeReal Salt Lak |
| |
| 25 Nov 21 | QF | Colorado RapidsColorado Rapi | 0 - 1 | Portland TimbersPortland Timb |
| 28 Nov 21 | QF | Sporting Kansas CitySporting Kans | 1 - 2 | Real Salt LakeReal Salt Lak |
| 28 Nov 21 | QF | Philadelphia UnionPhiladelphia | 1 - 1 | Nashville SCNashville SC |
| 01 Dec 21 | QF | New England Rev.New England R | 2 - 2 | New York CityNew York City |
| |
| 04 Dec 21 | SF | Portland TimbersPortland Timb | 2 - 0 | Real Salt LakeReal Salt Lak |
| 05 Dec 21 | SF | Philadelphia UnionPhiladelphia | 1 - 2 | New York CityNew York City |
| |
| 11 Dec 21 | Final | Portland TimbersPortland Timb | 1 - 1 | New York CityNew York City |
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