| 17 Apr 21 | r01        | Houston DynamoHouston Dynam | 2 - 1 | San Jose EarthquakesSan Jose Eart |
| 17 Apr 21 | r01        | Seattle Sounders FCSeattle Sound | 4 - 0 | Minnesota UnitedMinnesota Uni |
| 17 Apr 21 | r01        | CF MontréalCF Montréal | 4 - 2 | Toronto FCToronto FC |
| 17 Apr 21 | r01        | Orlando CityOrlando City | 0 - 0 | Atlanta UnitedAtlanta Unite |
| 18 Apr 21 | r01        | New York Red BullsNew York Red | 1 - 2 | Sporting Kansas CitySporting Kans |
| 18 Apr 21 | r01        | FC DallasFC Dallas | 0 - 0 | Colorado RapidsColorado Rapi |
| 18 Apr 21 | r01        | DC UnitedDC United | 2 - 1 | New York CityNew York City |
| 18 Apr 21 | r01        | Nashville SCNashville SC | 2 - 2 | FC CincinnatiFC Cincinnati |
| 18 Apr 21 | r01        | Chicago FireChicago Fire | 2 - 2 | New England Rev.New England R |
| |
| 18 Apr 21 | r02        | Inter MiamiInter Miami | 2 - 3 | L.A. GalaxyL.A. Galaxy |
| 18 Apr 21 | r02        | Columbus CrewColumbus Crew | 0 - 0 | Philadelphia UnionPhiladelphia |
| |
| 18 Apr 21 | r01        | Los Angeles FCLos Angeles F | 2 - 0 | Austin FCAustin FC |
| |
| 19 Apr 21 | r02        | Vancouver WhitecapsVancouver Whi | 1 - 0 | Portland TimbersPortland Timb |
| 24 Apr 21 | r02        | Sporting Kansas CitySporting Kans | 1 - 1 | Orlando CityOrlando City |
| 24 Apr 21 | r02        | New York CityNew York City | 5 - 0 | FC CincinnatiFC Cincinnati |
| |
| 24 Apr 21 | r03        | Nashville SCNashville SC | 2 - 2 | CF MontréalCF Montréal |
| |
| 24 Apr 21 | r02        | Toronto FCToronto FC | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 24 Apr 21 | r02        | San Jose EarthquakesSan Jose Eart | 3 - 1 | FC DallasFC Dallas |
| 25 Apr 21 | r02        | Atlanta UnitedAtlanta Unite | 3 - 1 | Chicago FireChicago Fire |
| 25 Apr 21 | r02        | Minnesota UnitedMinnesota Uni | 1 - 2 | Real Salt LakeReal Salt Lak |
| 25 Apr 21 | r02        | New England Rev.New England R | 1 - 0 | DC UnitedDC United |
| |
| 25 Apr 21 | r03        | Philadelphia UnionPhiladelphia | 1 - 2 | Inter MiamiInter Miami |
| 25 Apr 21 | r03        | Colorado RapidsColorado Rapi | 1 - 3 | Austin FCAustin FC |
| 25 Apr 21 | r03        | Portland TimbersPortland Timb | 2 - 1 | Houston DynamoHouston Dynam |
| 25 Apr 21 | r03        | L.A. GalaxyL.A. Galaxy | 3 - 2 | New York Red BullsNew York Red |
| |
| 25 Apr 21 | r02        | Los Angeles FCLos Angeles F | 1 - 1 | Seattle Sounders FCSeattle Sound |
| |
| 01 May 21 | r03        | New York Red BullsNew York Red | 2 - 0 | Chicago FireChicago Fire |
| 01 May 21 | r03        | Real Salt LakeReal Salt Lak | 3 - 1 | Sporting Kansas CitySporting Kans |
| |
| 01 May 21 | r04        | CF MontréalCF Montréal | 0 - 0 | Columbus CrewColumbus Crew |
| |
| 01 May 21 | r03        | Houston DynamoHouston Dynam | 1 - 1 | Los Angeles FCLos Angeles F |
| |
| 02 May 21 | r04        | New England Rev.New England R | 2 - 1 | Atlanta UnitedAtlanta Unite |
| 02 May 21 | r04        | Orlando CityOrlando City | 3 - 0 | FC CincinnatiFC Cincinnati |
| 02 May 21 | r04        | Philadelphia UnionPhiladelphia | 0 - 2 | New York CityNew York City |
| 02 May 21 | r04        | FC DallasFC Dallas | 4 - 1 | Portland TimbersPortland Timb |
| 02 May 21 | r04        | Minnesota UnitedMinnesota Uni | 0 - 1 | Austin FCAustin FC |
| 02 May 21 | r04        | San Jose EarthquakesSan Jose Eart | 4 - 1 | DC UnitedDC United |
| 02 May 21 | r04        | Nashville SCNashville SC | 0 - 0 | Inter MiamiInter Miami |
| 03 May 21 | r04        | Seattle Sounders FCSeattle Sound | 3 - 0 | L.A. GalaxyL.A. Galaxy |
| 03 May 21 | r04        | Vancouver WhitecapsVancouver Whi | 0 - 1 | Colorado RapidsColorado Rapi |
| 08 May 21 | r04        | Real Salt LakeReal Salt Lak | 1 - 2 | San Jose EarthquakesSan Jose Eart |
| |
| 08 May 21 | r05        | New York Red BullsNew York Red | 2 - 0 | Toronto FCToronto FC |
| 08 May 21 | r05        | Chicago FireChicago Fire | 0 - 2 | Philadelphia UnionPhiladelphia |
| 08 May 21 | r05        | Nashville SCNashville SC | 2 - 0 | New England Rev.New England R |
| 08 May 21 | r05        | Columbus CrewColumbus Crew | 3 - 1 | DC UnitedDC United |
| |
| 08 May 21 | r06        | Vancouver WhitecapsVancouver Whi | 2 - 0 | CF MontréalCF Montréal |
| |
| 08 May 21 | r05        | FC DallasFC Dallas | 1 - 1 | Houston DynamoHouston Dynam |
| 09 May 21 | r05        | L.A. GalaxyL.A. Galaxy | 2 - 1 | Los Angeles FCLos Angeles F |
| 09 May 21 | r05        | Colorado RapidsColorado Rapi | 3 - 2 | Minnesota UnitedMinnesota Uni |
| 09 May 21 | r05        | Inter MiamiInter Miami | 1 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 09 May 21 | r06        | Portland TimbersPortland Timb | 1 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 09 May 21 | r05        | Orlando CityOrlando City | 1 - 1 | New York CityNew York City |
| |
| 11 May 21 | r06        | Sporting Kansas CitySporting Kans | 2 - 1 | Austin FCAustin FC |
| 13 May 21 | r06        | Toronto FCToronto FC | 2 - 0 | Columbus CrewColumbus Crew |
| 13 May 21 | r06        | Houston DynamoHouston Dynam | 1 - 0 | Sporting Kansas CitySporting Kans |
| 13 May 21 | r06        | Minnesota UnitedMinnesota Uni | 1 - 0 | Vancouver WhitecapsVancouver Whi |
| 13 May 21 | r06        | San Jose EarthquakesSan Jose Eart | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 14 May 21 | r06        | Philadelphia UnionPhiladelphia | 1 - 1 | New England Rev.New England R |
| 14 May 21 | r06        | Inter MiamiInter Miami | 0 - 2 | CF MontréalCF Montréal |
| 14 May 21 | r06        | DC UnitedDC United | 1 - 0 | Chicago FireChicago Fire |
| 15 May 21 | r06        | New York CityNew York City | 1 - 1 | Toronto FCToronto FC |
| |
| 15 May 21 | r07        | L.A. GalaxyL.A. Galaxy | 2 - 0 | Austin FCAustin FC |
| 16 May 21 | r07        | Atlanta UnitedAtlanta Unite | 1 - 0 | CF MontréalCF Montréal |
| 16 May 21 | r07        | Minnesota UnitedMinnesota Uni | 1 - 0 | FC DallasFC Dallas |
| 16 May 21 | r07        | Colorado RapidsColorado Rapi | 3 - 1 | Houston DynamoHouston Dynam |
| 16 May 21 | r07        | Real Salt LakeReal Salt Lak | 0 - 0 | Nashville SCNashville SC |
| 16 May 21 | r07        | San Jose EarthquakesSan Jose Eart | 0 - 2 | Portland TimbersPortland Timb |
| 16 May 21 | r07        | Sporting Kansas CitySporting Kans | 3 - 0 | Vancouver WhitecapsVancouver Whi |
| |
| 16 May 21 | r03        | FC CincinnatiFC Cincinnati | 2 - 3 | Inter MiamiInter Miami |
| |
| 17 May 21 | r07        | Philadelphia UnionPhiladelphia | 1 - 0 | New York Red BullsNew York Red |
| |
| 17 May 21 | r08        | DC UnitedDC United | 0 - 1 | Orlando CityOrlando City |
| 17 May 21 | r08        | Seattle Sounders FCSeattle Sound | 2 - 0 | Los Angeles FCLos Angeles F |
| |
| 17 May 21 | r07        | New England Rev.New England R | 1 - 0 | Columbus CrewColumbus Crew |
| |
| 22 May 21 | r08        | CF MontréalCF Montréal | 1 - 2 | FC CincinnatiFC Cincinnati |
| |
| 22 May 21 | r09        | Portland TimbersPortland Timb | 3 - 0 | L.A. GalaxyL.A. Galaxy |
| 22 May 21 | r09        | Chicago FireChicago Fire | 1 - 0 | Inter MiamiInter Miami |
| |
| 23 May 21 | r08        | Orlando CityOrlando City | 1 - 0 | Toronto FCToronto FC |
| 23 May 21 | r08        | FC DallasFC Dallas | 2 - 2 | Real Salt LakeReal Salt Lak |
| 23 May 21 | r08        | New England Rev.New England R | 3 - 1 | New York Red BullsNew York Red |
| 23 May 21 | r08        | Houston DynamoHouston Dynam | 2 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 23 May 21 | r09        | San Jose EarthquakesSan Jose Eart | 1 - 3 | Sporting Kansas CitySporting Kans |
| 23 May 21 | r09        | Los Angeles FCLos Angeles F | 2 - 1 | Colorado RapidsColorado Rapi |
| 23 May 21 | r09        | Seattle Sounders FCSeattle Sound | 1 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 23 May 21 | r08        | New York CityNew York City | 1 - 2 | Columbus CrewColumbus Crew |
| |
| 24 May 21 | r09        | Nashville SCNashville SC | 1 - 0 | Austin FCAustin FC |
| 25 May 21 | r09        | DC UnitedDC United | 0 - 1 | Philadelphia UnionPhiladelphia |
| 29 May 21 | r09        | New York Red BullsNew York Red | 2 - 1 | Orlando CityOrlando City |
| |
| 29 May 21 | r10        | Chicago FireChicago Fire | 0 - 1 | CF MontréalCF Montréal |
| |
| 29 May 21 | r09        | FC CincinnatiFC Cincinnati | 0 - 1 | New England Rev.New England R |
| 29 May 21 | r09        | Columbus CrewColumbus Crew | 2 - 1 | Toronto FCToronto FC |
| |
| 29 May 21 | r10        | Atlanta UnitedAtlanta Unite | 2 - 2 | Nashville SCNashville SC |
| 29 May 21 | r10        | Los Angeles FCLos Angeles F | 1 - 2 | New York CityNew York City |
| 30 May 21 | r10        | L.A. GalaxyL.A. Galaxy | 1 - 0 | San Jose EarthquakesSan Jose Eart |
| |
| 30 May 21 | r09        | Inter MiamiInter Miami | 0 - 3 | DC UnitedDC United |
| |
| 30 May 21 | r10        | Sporting Kansas CitySporting Kans | 3 - 2 | Houston DynamoHouston Dynam |
| 30 May 21 | r10        | Colorado RapidsColorado Rapi | 3 - 0 | FC DallasFC Dallas |
| 30 May 21 | r10        | Real Salt LakeReal Salt Lak | 1 - 1 | Minnesota UnitedMinnesota Uni |
| 31 May 21 | r10        | Philadelphia UnionPhiladelphia | 3 - 0 | Portland TimbersPortland Timb |
| 31 May 21 | r10        | Seattle Sounders FCSeattle Sound | 0 - 0 | Austin FCAustin FC |
| |
| 12 Jun 21 | r17        | Sporting Kansas CitySporting Kans | 1 - 1 | Austin FCAustin FC |
| |
| 19 Jun 21 | r10        | New York Red BullsNew York Red | 2 - 0 | Nashville SCNashville SC |
| 19 Jun 21 | r10        | Real Salt LakeReal Salt Lak | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 19 Jun 21 | r11        | New York CityNew York City | 2 - 3 | New England Rev.New England R |
| 20 Jun 21 | r11        | FC CincinnatiFC Cincinnati | 0 - 2 | Colorado RapidsColorado Rapi |
| 20 Jun 21 | r11        | Columbus CrewColumbus Crew | 2 - 0 | Chicago FireChicago Fire |
| 20 Jun 21 | r11        | Toronto FCToronto FC | 2 - 3 | Orlando CityOrlando City |
| 20 Jun 21 | r11        | DC UnitedDC United | 1 - 0 | Inter MiamiInter Miami |
| 20 Jun 21 | r11        | FC DallasFC Dallas | 1 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 20 Jun 21 | r03        | Austin FCAustin FC | 0 - 0 | San Jose EarthquakesSan Jose Eart |
| |
| 20 Jun 21 | r11        | L.A. GalaxyL.A. Galaxy | 1 - 2 | Seattle Sounders FCSeattle Sound |
| 20 Jun 21 | r11        | Portland TimbersPortland Timb | 2 - 1 | Sporting Kansas CitySporting Kans |
| 20 Jun 21 | r11        | Los Angeles FCLos Angeles F | 1 - 1 | Houston DynamoHouston Dynam |
| |
| 20 Jun 21 | r12        | Atlanta UnitedAtlanta Unite | 2 - 2 | Philadelphia UnionPhiladelphia |
| 23 Jun 21 | r12        | Orlando CityOrlando City | 5 - 0 | San Jose EarthquakesSan Jose Eart |
| 23 Jun 21 | r12        | New York CityNew York City | 1 - 0 | Atlanta UnitedAtlanta Unite |
| 24 Jun 21 | r12        | New England Rev.New England R | 3 - 2 | New York Red BullsNew York Red |
| 24 Jun 21 | r12        | Philadelphia UnionPhiladelphia | 1 - 0 | Columbus CrewColumbus Crew |
| 24 Jun 21 | r12        | Minnesota UnitedMinnesota Uni | 2 - 0 | Austin FCAustin FC |
| 24 Jun 21 | r12        | Chicago FireChicago Fire | 0 - 1 | FC CincinnatiFC Cincinnati |
| |
| 24 Jun 21 | r11        | CF MontréalCF Montréal | 0 - 0 | DC UnitedDC United |
| |
| 24 Jun 21 | r12        | Houston DynamoHouston Dynam | 2 - 2 | Portland TimbersPortland Timb |
| 24 Jun 21 | r12        | Sporting Kansas CitySporting Kans | 3 - 1 | Colorado RapidsColorado Rapi |
| |
| 24 Jun 21 | r13        | Nashville SCNashville SC | 3 - 2 | Toronto FCToronto FC |
| 24 Jun 21 | r13        | Seattle Sounders FCSeattle Sound | 2 - 1 | Real Salt LakeReal Salt Lak |
| 24 Jun 21 | r13        | Los Angeles FCLos Angeles F | 2 - 0 | FC DallasFC Dallas |
| 24 Jun 21 | r13        | Vancouver WhitecapsVancouver Whi | 1 - 2 | L.A. GalaxyL.A. Galaxy |
| 26 Jun 21 | r13        | Inter MiamiInter Miami | 1 - 2 | Orlando CityOrlando City |
| 26 Jun 21 | r13        | Sporting Kansas CitySporting Kans | 2 - 1 | Los Angeles FCLos Angeles F |
| 27 Jun 21 | r13        | Toronto FCToronto FC | 0 - 2 | FC CincinnatiFC Cincinnati |
| 27 Jun 21 | r13        | Chicago FireChicago Fire | 3 - 3 | Philadelphia UnionPhiladelphia |
| 27 Jun 21 | r13        | Real Salt LakeReal Salt Lak | 1 - 1 | Houston DynamoHouston Dynam |
| 27 Jun 21 | r13        | Nashville SCNashville SC | 1 - 1 | CF MontréalCF Montréal |
| |
| 27 Jun 21 | r14        | Seattle Sounders FCSeattle Sound | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 27 Jun 21 | r14        | San Jose EarthquakesSan Jose Eart | 1 - 3 | L.A. GalaxyL.A. Galaxy |
| 27 Jun 21 | r14        | Portland TimbersPortland Timb | 0 - 1 | Minnesota UnitedMinnesota Uni |
| 27 Jun 21 | r14        | Atlanta UnitedAtlanta Unite | 0 - 0 | New York Red BullsNew York Red |
| 27 Jun 21 | r14        | New York CityNew York City | 2 - 1 | DC UnitedDC United |
| 28 Jun 21 | r14        | Austin FCAustin FC | 0 - 0 | Columbus CrewColumbus Crew |
| 28 Jun 21 | r14        | FC DallasFC Dallas | 2 - 1 | New England Rev.New England R |
| |
| 02 Jul 21 | r15        | Austin FCAustin FC | 4 - 1 | Portland TimbersPortland Timb |
| |
| 03 Jul 21 | r14        | Columbus CrewColumbus Crew | 2 - 2 | New England Rev.New England R |
| 03 Jul 21 | r14        | DC UnitedDC United | 7 - 1 | Toronto FCToronto FC |
| 03 Jul 21 | r14        | CF MontréalCF Montréal | 1 - 0 | Inter MiamiInter Miami |
| 04 Jul 21 | r14        | Orlando CityOrlando City | 1 - 2 | New York Red BullsNew York Red |
| |
| 04 Jul 21 | r15        | Minnesota UnitedMinnesota Uni | 2 - 2 | San Jose EarthquakesSan Jose Eart |
| 04 Jul 21 | r15        | Chicago FireChicago Fire | 3 - 0 | Atlanta UnitedAtlanta Unite |
| 04 Jul 21 | r15        | Nashville SCNashville SC | 1 - 0 | Philadelphia UnionPhiladelphia |
| 04 Jul 21 | r15        | Houston DynamoHouston Dynam | 1 - 1 | FC CincinnatiFC Cincinnati |
| 04 Jul 21 | r15        | Real Salt LakeReal Salt Lak | 0 - 1 | Los Angeles FCLos Angeles F |
| 05 Jul 21 | r15        | FC DallasFC Dallas | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 05 Jul 21 | r15        | Colorado RapidsColorado Rapi | 1 - 1 | Seattle Sounders FCSeattle Sound |
| 05 Jul 21 | r15        | L.A. GalaxyL.A. Galaxy | 0 - 2 | Sporting Kansas CitySporting Kans |
| |
| 08 Jul 21 | r16        | New England Rev.New England R | 2 - 3 | Toronto FCToronto FC |
| 08 Jul 21 | r16        | CF MontréalCF Montréal | 2 - 1 | New York CityNew York City |
| 08 Jul 21 | r16        | Chicago FireChicago Fire | 3 - 1 | Orlando CityOrlando City |
| 08 Jul 21 | r16        | Austin FCAustin FC | 0 - 2 | Los Angeles FCLos Angeles F |
| 08 Jul 21 | r16        | Colorado RapidsColorado Rapi | 2 - 0 | Minnesota UnitedMinnesota Uni |
| 08 Jul 21 | r16        | Seattle Sounders FCSeattle Sound | 2 - 0 | Houston DynamoHouston Dynam |
| 08 Jul 21 | r16        | Vancouver WhitecapsVancouver Whi | 0 - 4 | Real Salt LakeReal Salt Lak |
| 08 Jul 21 | r16        | L.A. GalaxyL.A. Galaxy | 3 - 1 | FC DallasFC Dallas |
| 09 Jul 21 | r16        | New York Red BullsNew York Red | 1 - 1 | Philadelphia UnionPhiladelphia |
| |
| 09 Jul 21 | r17        | Nashville SCNashville SC | 2 - 2 | Atlanta UnitedAtlanta Unite |
| |
| 10 Jul 21 | r16        | FC CincinnatiFC Cincinnati | 2 - 2 | Columbus CrewColumbus Crew |
| |
| 17 Jul 21 | r17        | Atlanta UnitedAtlanta Unite | 0 - 1 | New England Rev.New England R |
| 18 Jul 21 | r17        | Columbus CrewColumbus Crew | 2 - 1 | New York CityNew York City |
| 18 Jul 21 | r17        | Philadelphia UnionPhiladelphia | 2 - 1 | DC UnitedDC United |
| 18 Jul 21 | r17        | Toronto FCToronto FC | 1 - 1 | Orlando CityOrlando City |
| |
| 18 Jul 21 | r18        | CF MontréalCF Montréal | 5 - 4 | FC CincinnatiFC Cincinnati |
| |
| 18 Jul 21 | r17        | Nashville SCNashville SC | 5 - 1 | Chicago FireChicago Fire |
| 18 Jul 21 | r17        | Colorado RapidsColorado Rapi | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| |
| 18 Jul 21 | r18        | Vancouver WhitecapsVancouver Whi | 2 - 1 | L.A. GalaxyL.A. Galaxy |
| 18 Jul 21 | r18        | Los Angeles FCLos Angeles F | 2 - 1 | Real Salt LakeReal Salt Lak |
| 18 Jul 21 | r18        | Portland TimbersPortland Timb | 1 - 0 | FC DallasFC Dallas |
| 18 Jul 21 | r18        | Minnesota UnitedMinnesota Uni | 1 - 0 | Seattle Sounders FCSeattle Sound |
| |
| 21 Jul 21 | r19        | Vancouver WhitecapsVancouver Whi | 0 - 0 | Houston DynamoHouston Dynam |
| |
| 21 Jul 21 | r18        | New York CityNew York City | 1 - 0 | CF MontréalCF Montréal |
| 22 Jul 21 | r18        | Inter MiamiInter Miami | 0 - 5 | New England Rev.New England R |
| 22 Jul 21 | r18        | Columbus CrewColumbus Crew | 0 - 0 | Nashville SCNashville SC |
| 22 Jul 21 | r18        | Toronto FCToronto FC | 1 - 1 | New York Red BullsNew York Red |
| 22 Jul 21 | r18        | FC CincinnatiFC Cincinnati | 1 - 1 | Atlanta UnitedAtlanta Unite |
| 22 Jul 21 | r18        | Chicago FireChicago Fire | 2 - 2 | DC UnitedDC United |
| |
| 22 Jul 21 | r19        | Sporting Kansas CitySporting Kans | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 22 Jul 21 | r19        | Colorado RapidsColorado Rapi | 2 - 0 | FC DallasFC Dallas |
| |
| 22 Jul 21 | r18        | Real Salt LakeReal Salt Lak | 2 - 2 | L.A. GalaxyL.A. Galaxy |
| |
| 22 Jul 21 | r19        | L.A. GalaxyL.A. Galaxy | 2 - 2 | Real Salt LakeReal Salt Lak |
| 22 Jul 21 | r19        | Portland TimbersPortland Timb | 2 - 1 | Los Angeles FCLos Angeles F |
| 23 Jul 21 | r19        | Orlando CityOrlando City | 2 - 1 | Philadelphia UnionPhiladelphia |
| 23 Jul 21 | r19        | Austin FCAustin FC | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 24 Jul 21 | r19        | Atlanta UnitedAtlanta Unite | 0 - 1 | Columbus CrewColumbus Crew |
| 25 Jul 21 | r19        | Minnesota UnitedMinnesota Uni | 2 - 1 | Portland TimbersPortland Timb |
| |
| 25 Jul 21 | r20        | Chicago FireChicago Fire | 1 - 2 | Toronto FCToronto FC |
| 25 Jul 21 | r20        | FC DallasFC Dallas | 4 - 0 | L.A. GalaxyL.A. Galaxy |
| 25 Jul 21 | r20        | Nashville SCNashville SC | 3 - 0 | FC CincinnatiFC Cincinnati |
| 25 Jul 21 | r20        | San Jose EarthquakesSan Jose Eart | 1 - 1 | Houston DynamoHouston Dynam |
| 25 Jul 21 | r20        | Real Salt LakeReal Salt Lak | 3 - 0 | Colorado RapidsColorado Rapi |
| 25 Jul 21 | r20        | Los Angeles FCLos Angeles F | 2 - 2 | Vancouver WhitecapsVancouver Whi |
| 25 Jul 21 | r20        | New York CityNew York City | 5 - 0 | Orlando CityOrlando City |
| |
| 25 Jul 21 | r19        | New England Rev.New England R | 2 - 1 | CF MontréalCF Montréal |
| 26 Jul 21 | r19        | Inter MiamiInter Miami | 1 - 1 | Philadelphia UnionPhiladelphia |
| |
| 26 Jul 21 | r20        | DC UnitedDC United | 1 - 0 | New York Red BullsNew York Red |
| 26 Jul 21 | r20        | Seattle Sounders FCSeattle Sound | 1 - 3 | Sporting Kansas CitySporting Kans |
| |
| 29 Jul 21 | r21        | Los Angeles FCLos Angeles F | 2 - 2 | Minnesota UnitedMinnesota Uni |
| 31 Jul 21 | r21        | New York CityNew York City | 4 - 1 | Columbus CrewColumbus Crew |
| 31 Jul 21 | r21        | Orlando CityOrlando City | 3 - 2 | Atlanta UnitedAtlanta Unite |
| 31 Jul 21 | r21        | L.A. GalaxyL.A. Galaxy | 4 - 1 | Portland TimbersPortland Timb |
| 31 Jul 21 | r21        | New York Red BullsNew York Red | 2 - 3 | New England Rev.New England R |
| 31 Jul 21 | r21        | Seattle Sounders FCSeattle Sound | 0 - 1 | San Jose EarthquakesSan Jose Eart |
| 01 Aug 21 | r21        | FC CincinnatiFC Cincinnati | 0 - 0 | DC UnitedDC United |
| |
| 01 Aug 21 | r20        | Inter MiamiInter Miami | 2 - 1 | CF MontréalCF Montréal |
| |
| 01 Aug 21 | r21        | Houston DynamoHouston Dynam | 0 - 0 | Real Salt LakeReal Salt Lak |
| |
| 01 Aug 21 | r22        | Sporting Kansas CitySporting Kans | 1 - 2 | FC DallasFC Dallas |
| 01 Aug 21 | r22        | Austin FCAustin FC | 0 - 1 | Colorado RapidsColorado Rapi |
| 01 Aug 21 | r22        | Vancouver WhitecapsVancouver Whi | 2 - 2 | Minnesota UnitedMinnesota Uni |
| 01 Aug 21 | r22        | Philadelphia UnionPhiladelphia | 1 - 1 | Chicago FireChicago Fire |
| 02 Aug 21 | r22        | Toronto FCToronto FC | 1 - 1 | Nashville SCNashville SC |
| 05 Aug 21 | r22        | New England Rev.New England R | 0 - 0 | Nashville SCNashville SC |
| |
| 05 Aug 21 | r23        | New York Red BullsNew York Red | 0 - 0 | FC CincinnatiFC Cincinnati |
| |
| 05 Aug 21 | r22        | Columbus CrewColumbus Crew | 2 - 4 | DC UnitedDC United |
| 05 Aug 21 | r22        | Philadelphia UnionPhiladelphia | 3 - 0 | Toronto FCToronto FC |
| |
| 05 Aug 21 | r21        | CF MontréalCF Montréal | 2 - 2 | Atlanta UnitedAtlanta Unite |
| |
| 05 Aug 21 | r22        | Orlando CityOrlando City | 1 - 1 | Inter MiamiInter Miami |
| |
| 05 Aug 21 | r23        | Chicago FireChicago Fire | 0 - 0 | New York CityNew York City |
| 05 Aug 21 | r23        | Austin FCAustin FC | 3 - 2 | Houston DynamoHouston Dynam |
| |
| 05 Aug 21 | r21        | L.A. GalaxyL.A. Galaxy | 1 - 0 | Real Salt LakeReal Salt Lak |
| |
| 05 Aug 21 | r23        | Seattle Sounders FCSeattle Sound | 1 - 1 | FC DallasFC Dallas |
| 05 Aug 21 | r23        | Los Angeles FCLos Angeles F | 1 - 4 | Sporting Kansas CitySporting Kans |
| 05 Aug 21 | r23        | Portland TimbersPortland Timb | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 05 Aug 21 | r23        | Real Salt LakeReal Salt Lak | 1 - 0 | L.A. GalaxyL.A. Galaxy |
| 08 Aug 21 | r23        | FC CincinnatiFC Cincinnati | 1 - 1 | Orlando CityOrlando City |
| |
| 08 Aug 21 | r24        | Columbus CrewColumbus Crew | 2 - 3 | Atlanta UnitedAtlanta Unite |
| 08 Aug 21 | r24        | Minnesota UnitedMinnesota Uni | 2 - 0 | Houston DynamoHouston Dynam |
| 08 Aug 21 | r24        | Toronto FCToronto FC | 2 - 2 | New York CityNew York City |
| 08 Aug 21 | r24        | FC DallasFC Dallas | 2 - 0 | Austin FCAustin FC |
| 08 Aug 21 | r24        | Colorado RapidsColorado Rapi | 0 - 0 | Sporting Kansas CitySporting Kans |
| 08 Aug 21 | r24        | Portland TimbersPortland Timb | 3 - 2 | Real Salt LakeReal Salt Lak |
| |
| 08 Aug 21 | r23        | Inter MiamiInter Miami | 2 - 1 | Nashville SCNashville SC |
| |
| 08 Aug 21 | r24        | Chicago FireChicago Fire | 2 - 1 | New York Red BullsNew York Red |
| 08 Aug 21 | r24        | New England Rev.New England R | 2 - 1 | Philadelphia UnionPhiladelphia |
| 09 Aug 21 | r24        | San Jose EarthquakesSan Jose Eart | 2 - 1 | Los Angeles FCLos Angeles F |
| 09 Aug 21 | r24        | L.A. GalaxyL.A. Galaxy | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 09 Aug 21 | r23        | DC UnitedDC United | 2 - 1 | CF MontréalCF Montréal |
| |
| 14 Aug 21 | r25        | San Jose EarthquakesSan Jose Eart | 0 - 0 | Vancouver WhitecapsVancouver Whi |
| 14 Aug 21 | r25        | Minnesota UnitedMinnesota Uni | 0 - 1 | L.A. GalaxyL.A. Galaxy |
| 15 Aug 21 | r25        | New York CityNew York City | 2 - 0 | Inter MiamiInter Miami |
| 15 Aug 21 | r25        | Toronto FCToronto FC | 1 - 2 | New England Rev.New England R |
| |
| 15 Aug 21 | r24        | CF MontréalCF Montréal | 2 - 1 | New York Red BullsNew York Red |
| |
| 15 Aug 21 | r25        | FC DallasFC Dallas | 0 - 2 | Sporting Kansas CitySporting Kans |
| 15 Aug 21 | r25        | Houston DynamoHouston Dynam | 1 - 3 | Colorado RapidsColorado Rapi |
| |
| 15 Aug 21 | r26        | Real Salt LakeReal Salt Lak | 1 - 0 | Austin FCAustin FC |
| 15 Aug 21 | r26        | Atlanta UnitedAtlanta Unite | 1 - 0 | Los Angeles FCLos Angeles F |
| |
| 15 Aug 21 | r25        | Chicago FireChicago Fire | 1 - 0 | Columbus CrewColumbus Crew |
| |
| 16 Aug 21 | r26        | Nashville SCNashville SC | 5 - 2 | DC UnitedDC United |
| 16 Aug 21 | r26        | Portland TimbersPortland Timb | 2 - 6 | Seattle Sounders FCSeattle Sound |
| 18 Aug 21 | r26        | L.A. GalaxyL.A. Galaxy | 1 - 2 | Colorado RapidsColorado Rapi |
| 18 Aug 21 | r26        | San Jose EarthquakesSan Jose Eart | 1 - 1 | Minnesota UnitedMinnesota Uni |
| 19 Aug 21 | r26        | New England Rev.New England R | 3 - 2 | DC UnitedDC United |
| 19 Aug 21 | r26        | Atlanta UnitedAtlanta Unite | 1 - 0 | Toronto FCToronto FC |
| |
| 19 Aug 21 | r27        | New York Red BullsNew York Red | 1 - 0 | Columbus CrewColumbus Crew |
| |
| 19 Aug 21 | r26        | Inter MiamiInter Miami | 3 - 2 | Chicago FireChicago Fire |
| 19 Aug 21 | r26        | Philadelphia UnionPhiladelphia | 1 - 0 | New York CityNew York City |
| |
| 19 Aug 21 | r25        | FC CincinnatiFC Cincinnati | 0 - 0 | CF MontréalCF Montréal |
| |
| 19 Aug 21 | r27        | FC DallasFC Dallas | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 19 Aug 21 | r27        | Nashville SCNashville SC | 1 - 1 | Orlando CityOrlando City |
| 19 Aug 21 | r27        | Sporting Kansas CitySporting Kans | 1 - 1 | Portland TimbersPortland Timb |
| 19 Aug 21 | r27        | Austin FCAustin FC | 1 - 2 | Vancouver WhitecapsVancouver Whi |
| 19 Aug 21 | r27        | Real Salt LakeReal Salt Lak | 2 - 1 | Houston DynamoHouston Dynam |
| 21 Aug 21 | r27        | L.A. GalaxyL.A. Galaxy | 1 - 2 | San Jose EarthquakesSan Jose Eart |
| 21 Aug 21 | r27        | Minnesota UnitedMinnesota Uni | 0 - 0 | Sporting Kansas CitySporting Kans |
| |
| 21 Aug 21 | r28        | Columbus CrewColumbus Crew | 1 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 22 Aug 21 | r27        | Inter MiamiInter Miami | 3 - 1 | Toronto FCToronto FC |
| |
| 22 Aug 21 | r28        | Orlando CityOrlando City | 1 - 0 | Chicago FireChicago Fire |
| 22 Aug 21 | r28        | DC UnitedDC United | 1 - 2 | Atlanta UnitedAtlanta Unite |
| 22 Aug 21 | r28        | New England Rev.New England R | 4 - 1 | FC CincinnatiFC Cincinnati |
| |
| 22 Aug 21 | r27        | Philadelphia UnionPhiladelphia | 1 - 1 | CF MontréalCF Montréal |
| |
| 22 Aug 21 | r28        | Houston DynamoHouston Dynam | 2 - 2 | FC DallasFC Dallas |
| 22 Aug 21 | r28        | Austin FCAustin FC | 3 - 1 | Portland TimbersPortland Timb |
| 22 Aug 21 | r28        | Colorado RapidsColorado Rapi | 2 - 1 | Real Salt LakeReal Salt Lak |
| 22 Aug 21 | r28        | Vancouver WhitecapsVancouver Whi | 2 - 1 | Los Angeles FCLos Angeles F |
| |
| 27 Aug 21 | r29        | Columbus CrewColumbus Crew | 3 - 2 | FC CincinnatiFC Cincinnati |
| |
| 28 Aug 21 | r27        | CF MontréalCF Montréal | 3 - 1 | Toronto FCToronto FC |
| |
| 28 Aug 21 | r29        | Orlando CityOrlando City | 0 - 0 | Inter MiamiInter Miami |
| 28 Aug 21 | r29        | Atlanta UnitedAtlanta Unite | 0 - 2 | Nashville SCNashville SC |
| 28 Aug 21 | r29        | New York Red BullsNew York Red | 0 - 1 | Chicago FireChicago Fire |
| 29 Aug 21 | r29        | Los Angeles FCLos Angeles F | 3 - 3 | L.A. GalaxyL.A. Galaxy |
| 29 Aug 21 | r29        | New York CityNew York City | 2 - 0 | New England Rev.New England R |
| 29 Aug 21 | r29        | DC UnitedDC United | 3 - 1 | Philadelphia UnionPhiladelphia |
| 29 Aug 21 | r29        | Houston DynamoHouston Dynam | 1 - 2 | Minnesota UnitedMinnesota Uni |
| 29 Aug 21 | r29        | Sporting Kansas CitySporting Kans | 1 - 1 | Colorado RapidsColorado Rapi |
| |
| 30 Aug 21 | r30        | Austin FCAustin FC | 3 - 5 | FC DallasFC Dallas |
| 30 Aug 21 | r30        | Vancouver WhitecapsVancouver Whi | 4 - 1 | Real Salt LakeReal Salt Lak |
| 30 Aug 21 | r30        | Seattle Sounders FCSeattle Sound | 0 - 2 | Portland TimbersPortland Timb |
| 04 Sep 21 | r30        | Nashville SCNashville SC | 3 - 1 | New York CityNew York City |
| |
| 04 Sep 21 | r32        | Philadelphia UnionPhiladelphia | 0 - 1 | New England Rev.New England R |
| |
| 04 Sep 21 | r30        | Houston DynamoHouston Dynam | 0 - 2 | Portland TimbersPortland Timb |
| 04 Sep 21 | r30        | Los Angeles FCLos Angeles F | 4 - 0 | Sporting Kansas CitySporting Kans |
| |
| 05 Sep 21 | r21        | Vancouver WhitecapsVancouver Whi | 2 - 1 | Austin FCAustin FC |
| |
| 05 Sep 21 | r30        | Orlando CityOrlando City | 3 - 2 | Columbus CrewColumbus Crew |
| 05 Sep 21 | r30        | FC CincinnatiFC Cincinnati | 0 - 1 | Inter MiamiInter Miami |
| 05 Sep 21 | r30        | Real Salt LakeReal Salt Lak | 3 - 2 | FC DallasFC Dallas |
| 05 Sep 21 | r30        | San Jose EarthquakesSan Jose Eart | 0 - 1 | Colorado RapidsColorado Rapi |
| |
| 11 Sep 21 | r31        | Atlanta UnitedAtlanta Unite | 3 - 0 | Orlando CityOrlando City |
| 11 Sep 21 | r31        | Vancouver WhitecapsVancouver Whi | 0 - 1 | Portland TimbersPortland Timb |
| 11 Sep 21 | r31        | Colorado RapidsColorado Rapi | 1 - 1 | L.A. GalaxyL.A. Galaxy |
| 11 Sep 21 | r31        | Seattle Sounders FCSeattle Sound | 1 - 0 | Minnesota UnitedMinnesota Uni |
| 11 Sep 21 | r31        | New York Red BullsNew York Red | 1 - 1 | DC UnitedDC United |
| 12 Sep 21 | r31        | New England Rev.New England R | 2 - 1 | New York CityNew York City |
| 12 Sep 21 | r31        | Inter MiamiInter Miami | 1 - 0 | Columbus CrewColumbus Crew |
| 12 Sep 21 | r31        | FC CincinnatiFC Cincinnati | 2 - 0 | Toronto FCToronto FC |
| |
| 12 Sep 21 | r30        | CF MontréalCF Montréal | 0 - 1 | Nashville SCNashville SC |
| |
| 12 Sep 21 | r31        | FC DallasFC Dallas | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 12 Sep 21 | r31        | Houston DynamoHouston Dynam | 3 - 0 | Austin FCAustin FC |
| |
| 12 Sep 21 | r32        | Sporting Kansas CitySporting Kans | 2 - 0 | Chicago FireChicago Fire |
| 13 Sep 21 | r32        | Los Angeles FCLos Angeles F | 3 - 2 | Real Salt LakeReal Salt Lak |
| 14 Sep 21 | r32        | New York CityNew York City | 3 - 3 | FC DallasFC Dallas |
| 15 Sep 21 | r32        | Toronto FCToronto FC | 0 - 1 | Inter MiamiInter Miami |
| 15 Sep 21 | r32        | Columbus CrewColumbus Crew | 2 - 1 | New York Red BullsNew York Red |
| 16 Sep 21 | r32        | Atlanta UnitedAtlanta Unite | 4 - 0 | FC CincinnatiFC Cincinnati |
| 16 Sep 21 | r32        | DC UnitedDC United | 3 - 0 | Chicago FireChicago Fire |
| |
| 16 Sep 21 | r31        | Orlando CityOrlando City | 2 - 4 | CF MontréalCF Montréal |
| |
| 16 Sep 21 | r33        | Sporting Kansas CitySporting Kans | 4 - 0 | Minnesota UnitedMinnesota Uni |
| 16 Sep 21 | r33        | Austin FCAustin FC | 1 - 2 | Los Angeles FCLos Angeles F |
| 16 Sep 21 | r33        | Portland TimbersPortland Timb | 2 - 2 | Colorado RapidsColorado Rapi |
| 16 Sep 21 | r33        | L.A. GalaxyL.A. Galaxy | 1 - 1 | Houston DynamoHouston Dynam |
| 16 Sep 21 | r33        | San Jose EarthquakesSan Jose Eart | 3 - 4 | Real Salt LakeReal Salt Lak |
| 18 Sep 21 | r33        | Inter MiamiInter Miami | 0 - 4 | New York Red BullsNew York Red |
| 18 Sep 21 | r33        | Atlanta UnitedAtlanta Unite | 3 - 2 | DC UnitedDC United |
| 19 Sep 21 | r33        | New England Rev.New England R | 1 - 1 | Columbus CrewColumbus Crew |
| 19 Sep 21 | r33        | FC CincinnatiFC Cincinnati | 1 - 2 | New York CityNew York City |
| |
| 19 Sep 21 | r34        | Toronto FCToronto FC | 2 - 1 | Nashville SCNashville SC |
| 19 Sep 21 | r34        | Minnesota UnitedMinnesota Uni | 3 - 0 | L.A. GalaxyL.A. Galaxy |
| 19 Sep 21 | r34        | Austin FCAustin FC | 3 - 4 | San Jose EarthquakesSan Jose Eart |
| 19 Sep 21 | r34        | Houston DynamoHouston Dynam | 3 - 2 | FC DallasFC Dallas |
| 19 Sep 21 | r34        | Real Salt LakeReal Salt Lak | 1 - 0 | Seattle Sounders FCSeattle Sound |
| |
| 19 Sep 21 | r33        | CF MontréalCF Montréal | 2 - 0 | Chicago FireChicago Fire |
| |
| 19 Sep 21 | r34        | Philadelphia UnionPhiladelphia | 3 - 1 | Orlando CityOrlando City |
| 20 Sep 21 | r34        | Portland TimbersPortland Timb | 2 - 1 | Los Angeles FCLos Angeles F |
| 20 Sep 21 | r34        | Colorado RapidsColorado Rapi | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 23 Sep 21 | r28        | New York Red BullsNew York Red | 1 - 1 | New York CityNew York City |
| |
| 23 Sep 21 | r34        | Inter MiamiInter Miami | 1 - 5 | Nashville SCNashville SC |
| |
| 23 Sep 21 | r44        | Chicago FireChicago Fire | 2 - 3 | New England Rev.New England R |
| |
| 25 Sep 21 | r35        | Philadelphia UnionPhiladelphia | 1 - 0 | Atlanta UnitedAtlanta Unite |
| 26 Sep 21 | r35        | New England Rev.New England R | 2 - 1 | Orlando CityOrlando City |
| 26 Sep 21 | r35        | DC UnitedDC United | 4 - 2 | FC CincinnatiFC Cincinnati |
| |
| 26 Sep 21 | r34        | Columbus CrewColumbus Crew | 2 - 1 | CF MontréalCF Montréal |
| |
| 26 Sep 21 | r35        | New York CityNew York City | 0 - 1 | New York Red BullsNew York Red |
| 26 Sep 21 | r35        | Minnesota UnitedMinnesota Uni | 2 - 0 | Houston DynamoHouston Dynam |
| 26 Sep 21 | r35        | Colorado RapidsColorado Rapi | 0 - 0 | Toronto FCToronto FC |
| 26 Sep 21 | r35        | San Jose EarthquakesSan Jose Eart | 2 - 0 | Los Angeles FCLos Angeles F |
| 26 Sep 21 | r35        | Vancouver WhitecapsVancouver Whi | 1 - 0 | FC DallasFC Dallas |
| |
| 26 Sep 21 | r36        | Portland TimbersPortland Timb | 6 - 1 | Real Salt LakeReal Salt Lak |
| 26 Sep 21 | r36        | Chicago FireChicago Fire | 0 - 0 | Nashville SCNashville SC |
| 27 Sep 21 | r36        | Sporting Kansas CitySporting Kans | 1 - 2 | Seattle Sounders FCSeattle Sound |
| |
| 27 Sep 21 | r35        | Austin FCAustin FC | 2 - 0 | L.A. GalaxyL.A. Galaxy |
| |
| 29 Sep 21 | r36        | New York Red BullsNew York Red | 1 - 1 | Philadelphia UnionPhiladelphia |
| 30 Sep 21 | r36        | Toronto FCToronto FC | 3 - 2 | FC CincinnatiFC Cincinnati |
| 30 Sep 21 | r36        | Atlanta UnitedAtlanta Unite | 1 - 0 | Inter MiamiInter Miami |
| 30 Sep 21 | r36        | DC UnitedDC United | 3 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 30 Sep 21 | r35        | CF MontréalCF Montréal | 1 - 4 | New England Rev.New England R |
| |
| 30 Sep 21 | r36        | FC DallasFC Dallas | 1 - 3 | Sporting Kansas CitySporting Kans |
| 30 Sep 21 | r36        | Chicago FireChicago Fire | 2 - 0 | New York CityNew York City |
| |
| 30 Sep 21 | r37        | Nashville SCNashville SC | 2 - 2 | Orlando CityOrlando City |
| 30 Sep 21 | r37        | Colorado RapidsColorado Rapi | 3 - 0 | Austin FCAustin FC |
| 30 Sep 21 | r37        | Houston DynamoHouston Dynam | 0 - 0 | Vancouver WhitecapsVancouver Whi |
| 30 Sep 21 | r37        | Real Salt LakeReal Salt Lak | 2 - 1 | L.A. GalaxyL.A. Galaxy |
| 30 Sep 21 | r37        | Los Angeles FCLos Angeles F | 1 - 2 | Portland TimbersPortland Timb |
| 30 Sep 21 | r37        | San Jose EarthquakesSan Jose Eart | 1 - 3 | Seattle Sounders FCSeattle Sound |
| 02 Oct 21 | r37        | Austin FCAustin FC | 2 - 1 | Real Salt LakeReal Salt Lak |
| |
| 03 Oct 21 | r36        | CF MontréalCF Montréal | 2 - 1 | Atlanta UnitedAtlanta Unite |
| |
| 03 Oct 21 | r38        | FC CincinnatiFC Cincinnati | 0 - 1 | New York Red BullsNew York Red |
| 03 Oct 21 | r38        | Orlando CityOrlando City | 2 - 1 | DC UnitedDC United |
| 03 Oct 21 | r38        | FC DallasFC Dallas | 0 - 0 | Minnesota UnitedMinnesota Uni |
| 03 Oct 21 | r38        | Vancouver WhitecapsVancouver Whi | 3 - 0 | San Jose EarthquakesSan Jose Eart |
| 03 Oct 21 | r38        | New York CityNew York City | 0 - 0 | Nashville SCNashville SC |
| 03 Oct 21 | r38        | Philadelphia UnionPhiladelphia | 3 - 0 | Columbus CrewColumbus Crew |
| |
| 03 Oct 21 | r37        | Sporting Kansas CitySporting Kans | 4 - 2 | Houston DynamoHouston Dynam |
| |
| 03 Oct 21 | r38        | Toronto FCToronto FC | 3 - 1 | Chicago FireChicago Fire |
| |
| 03 Oct 21 | r37        | Portland TimbersPortland Timb | 1 - 0 | Inter MiamiInter Miami |
| |
| 04 Oct 21 | r38        | L.A. GalaxyL.A. Galaxy | 1 - 1 | Los Angeles FCLos Angeles F |
| 04 Oct 21 | r38        | Seattle Sounders FCSeattle Sound | 3 - 0 | Colorado RapidsColorado Rapi |
| |
| 09 Oct 21 | r17        | New York Red BullsNew York Red | 1 - 0 | Inter MiamiInter Miami |
| |
| 10 Oct 21 | r25        | FC CincinnatiFC Cincinnati | 1 - 2 | Philadelphia UnionPhiladelphia |
| |
| 10 Oct 21 | r33        | Seattle Sounders FCSeattle Sound | 4 - 1 | Vancouver WhitecapsVancouver Whi |
| |
| 10 Oct 21 | r23        | Minnesota UnitedMinnesota Uni | 1 - 3 | Colorado RapidsColorado Rapi |
| |
| 16 Oct 21 | r38        | CF MontréalCF Montréal | 2 - 2 | Philadelphia UnionPhiladelphia |
| |
| 16 Oct 21 | r39        | Los Angeles FCLos Angeles F | 3 - 1 | San Jose EarthquakesSan Jose Eart |
| 16 Oct 21 | r39        | Columbus CrewColumbus Crew | 4 - 0 | Inter MiamiInter Miami |
| 17 Oct 21 | r39        | New England Rev.New England R | 2 - 2 | Chicago FireChicago Fire |
| 17 Oct 21 | r39        | FC CincinnatiFC Cincinnati | 0 - 1 | Orlando CityOrlando City |
| 17 Oct 21 | r39        | DC UnitedDC United | 0 - 0 | Nashville SCNashville SC |
| 17 Oct 21 | r39        | Toronto FCToronto FC | 0 - 2 | Atlanta UnitedAtlanta Unite |
| 17 Oct 21 | r39        | Houston DynamoHouston Dynam | 2 - 1 | Seattle Sounders FCSeattle Sound |
| 17 Oct 21 | r39        | Austin FCAustin FC | 0 - 1 | Minnesota UnitedMinnesota Uni |
| 17 Oct 21 | r39        | Real Salt LakeReal Salt Lak | 3 - 1 | Colorado RapidsColorado Rapi |
| 17 Oct 21 | r39        | L.A. GalaxyL.A. Galaxy | 2 - 1 | Portland TimbersPortland Timb |
| |
| 17 Oct 21 | r40        | New York Red BullsNew York Red | 1 - 0 | New York CityNew York City |
| 18 Oct 21 | r40        | Vancouver WhitecapsVancouver Whi | 2 - 1 | Sporting Kansas CitySporting Kans |
| 21 Oct 21 | r40        | Inter MiamiInter Miami | 3 - 0 | Toronto FCToronto FC |
| 21 Oct 21 | r40        | FC CincinnatiFC Cincinnati | 3 - 4 | Chicago FireChicago Fire |
| 21 Oct 21 | r40        | Atlanta UnitedAtlanta Unite | 1 - 1 | New York CityNew York City |
| 21 Oct 21 | r40        | DC UnitedDC United | 2 - 3 | New England Rev.New England R |
| |
| 21 Oct 21 | r39        | Orlando CityOrlando City | 1 - 1 | CF MontréalCF Montréal |
| |
| 21 Oct 21 | r40        | FC DallasFC Dallas | 2 - 3 | Los Angeles FCLos Angeles F |
| 21 Oct 21 | r40        | Minnesota UnitedMinnesota Uni | 3 - 2 | Philadelphia UnionPhiladelphia |
| 21 Oct 21 | r40        | Houston DynamoHouston Dynam | 0 - 3 | L.A. GalaxyL.A. Galaxy |
| |
| 21 Oct 21 | r41        | Nashville SCNashville SC | 1 - 1 | Columbus CrewColumbus Crew |
| 21 Oct 21 | r41        | Colorado RapidsColorado Rapi | 1 - 1 | Seattle Sounders FCSeattle Sound |
| 21 Oct 21 | r41        | Portland TimbersPortland Timb | 2 - 3 | Vancouver WhitecapsVancouver Whi |
| 21 Oct 21 | r41        | San Jose EarthquakesSan Jose Eart | 4 - 0 | Austin FCAustin FC |
| |
| 23 Oct 21 | r42        | Seattle Sounders FCSeattle Sound | 1 - 2 | Sporting Kansas CitySporting Kans |
| |
| 23 Oct 21 | r41        | Columbus CrewColumbus Crew | 1 - 2 | New York Red BullsNew York Red |
| 24 Oct 21 | r41        | New York CityNew York City | 6 - 0 | DC UnitedDC United |
| |
| 24 Oct 21 | r42        | Philadelphia UnionPhiladelphia | 1 - 0 | Nashville SCNashville SC |
| |
| 24 Oct 21 | r40        | Toronto FCToronto FC | 1 - 1 | CF MontréalCF Montréal |
| |
| 24 Oct 21 | r41        | Inter MiamiInter Miami | 5 - 1 | FC CincinnatiFC Cincinnati |
| |
| 24 Oct 21 | r42        | Minnesota UnitedMinnesota Uni | 1 - 1 | Los Angeles FCLos Angeles F |
| 24 Oct 21 | r42        | Chicago FireChicago Fire | 1 - 0 | Real Salt LakeReal Salt Lak |
| 24 Oct 21 | r42        | Colorado RapidsColorado Rapi | 2 - 0 | Portland TimbersPortland Timb |
| |
| 24 Oct 21 | r41        | L.A. GalaxyL.A. Galaxy | 2 - 2 | FC DallasFC Dallas |
| |
| 24 Oct 21 | r42        | San Jose EarthquakesSan Jose Eart | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 24 Oct 21 | r42        | Austin FCAustin FC | 2 - 1 | Houston DynamoHouston Dynam |
| |
| 25 Oct 21 | r41        | Orlando CityOrlando City | 2 - 2 | New England Rev.New England R |
| |
| 27 Oct 21 | r42        | Los Angeles FCLos Angeles F | 3 - 0 | Seattle Sounders FCSeattle Sound |
| 28 Oct 21 | r42        | New England Rev.New England R | 1 - 0 | Colorado RapidsColorado Rapi |
| 28 Oct 21 | r42        | Atlanta UnitedAtlanta Unite | 2 - 1 | Inter MiamiInter Miami |
| |
| 28 Oct 21 | r43        | FC CincinnatiFC Cincinnati | 3 - 6 | Nashville SCNashville SC |
| 28 Oct 21 | r43        | New York CityNew York City | 1 - 0 | Chicago FireChicago Fire |
| 28 Oct 21 | r43        | Columbus CrewColumbus Crew | 3 - 2 | Orlando CityOrlando City |
| 28 Oct 21 | r43        | Toronto FCToronto FC | 2 - 2 | Philadelphia UnionPhiladelphia |
| 28 Oct 21 | r43        | DC UnitedDC United | 1 - 0 | New York Red BullsNew York Red |
| 28 Oct 21 | r43        | FC DallasFC Dallas | 1 - 2 | Real Salt LakeReal Salt Lak |
| 28 Oct 21 | r43        | Sporting Kansas CitySporting Kans | 2 - 0 | L.A. GalaxyL.A. Galaxy |
| 28 Oct 21 | r43        | Portland TimbersPortland Timb | 2 - 0 | San Jose EarthquakesSan Jose Eart |
| 28 Oct 21 | r43        | Vancouver WhitecapsVancouver Whi | 2 - 1 | Minnesota UnitedMinnesota Uni |
| |
| 30 Oct 21 | r44        | Inter MiamiInter Miami | 1 - 3 | New York CityNew York City |
| |
| 30 Oct 21 | r43        | New York Red BullsNew York Red | 1 - 0 | CF MontréalCF Montréal |
| |
| 30 Oct 21 | r44        | Real Salt LakeReal Salt Lak | 3 - 4 | San Jose EarthquakesSan Jose Eart |
| 31 Oct 21 | r44        | Atlanta UnitedAtlanta Unite | 1 - 1 | Toronto FCToronto FC |
| 31 Oct 21 | r44        | FC DallasFC Dallas | 2 - 1 | Austin FCAustin FC |
| 31 Oct 21 | r44        | DC UnitedDC United | 1 - 3 | Columbus CrewColumbus Crew |
| 31 Oct 21 | r44        | Minnesota UnitedMinnesota Uni | 2 - 1 | Sporting Kansas CitySporting Kans |
| 31 Oct 21 | r44        | Houston DynamoHouston Dynam | 0 - 1 | Colorado RapidsColorado Rapi |
| 31 Oct 21 | r44        | Orlando CityOrlando City | 1 - 1 | Nashville SCNashville SC |
| 31 Oct 21 | r44        | Philadelphia UnionPhiladelphia | 2 - 0 | FC CincinnatiFC Cincinnati |
| |
| 02 Nov 21 | r45        | Seattle Sounders FCSeattle Sound | 1 - 1 | L.A. GalaxyL.A. Galaxy |
| 03 Nov 21 | r45        | Los Angeles FCLos Angeles F | 1 - 1 | Vancouver WhitecapsVancouver Whi |
| 03 Nov 21 | r45        | New York Red BullsNew York Red | 0 - 0 | Atlanta UnitedAtlanta Unite |
| |
| 03 Nov 21 | r44        | CF MontréalCF Montréal | 2 - 0 | Houston DynamoHouston Dynam |
| |
| 04 Nov 21 | r45        | Austin FCAustin FC | 3 - 1 | Sporting Kansas CitySporting Kans |
| 04 Nov 21 | r45        | Real Salt LakeReal Salt Lak | 1 - 3 | Portland TimbersPortland Timb |
| 07 Nov 21 | r45        | FC CincinnatiFC Cincinnati | 1 - 2 | Atlanta UnitedAtlanta Unite |
| 07 Nov 21 | r45        | Columbus CrewColumbus Crew | 2 - 0 | Chicago FireChicago Fire |
| 07 Nov 21 | r45        | Nashville SCNashville SC | 1 - 1 | New York Red BullsNew York Red |
| 07 Nov 21 | r45        | New England Rev.New England R | 0 - 1 | Inter MiamiInter Miami |
| |
| 07 Nov 21 | r46        | New York CityNew York City | 1 - 1 | Philadelphia UnionPhiladelphia |
| 07 Nov 21 | r46        | Toronto FCToronto FC | 1 - 3 | DC UnitedDC United |
| |
| 07 Nov 21 | r45        | CF MontréalCF Montréal | 0 - 2 | Orlando CityOrlando City |
| |
| 07 Nov 21 | r46        | Colorado RapidsColorado Rapi | 5 - 2 | Los Angeles FCLos Angeles F |
| 07 Nov 21 | r46        | L.A. GalaxyL.A. Galaxy | 3 - 3 | Minnesota UnitedMinnesota Uni |
| 07 Nov 21 | r46        | Portland TimbersPortland Timb | 3 - 0 | Austin FCAustin FC |
| 07 Nov 21 | r46        | San Jose EarthquakesSan Jose Eart | 1 - 1 | FC DallasFC Dallas |
| 07 Nov 21 | r46        | Sporting Kansas CitySporting Kans | 0 - 1 | Real Salt LakeReal Salt Lak |
| 07 Nov 21 | r46        | Vancouver WhitecapsVancouver Whi | 1 - 1 | Seattle Sounders FCSeattle Sound |
| |
| 20 Nov 21 | Playoff        | Philadelphia UnionPhiladelphia | 1 - 0 | New York Red BullsNew York Red |
| 20 Nov 21 | Playoff        | Sporting Kansas CitySporting Kans | 3 - 1 | Vancouver WhitecapsVancouver Whi |
| 21 Nov 21 | Playoff        | New York CityNew York City | 2 - 0 | Atlanta UnitedAtlanta Unite |
| 21 Nov 21 | Playoff        | Portland TimbersPortland Timb | 3 - 1 | Minnesota UnitedMinnesota Uni |
| 24 Nov 21 | Playoff        | Nashville SCNashville SC | 3 - 1 | Orlando CityOrlando City |
| 24 Nov 21 | Playoff        | Seattle Sounders FCSeattle Sound | 0 - 0 | Real Salt LakeReal Salt Lak |
| |
| 25 Nov 21 | QF        | Colorado RapidsColorado Rapi | 0 - 1 | Portland TimbersPortland Timb |
| 28 Nov 21 | QF        | Sporting Kansas CitySporting Kans | 1 - 2 | Real Salt LakeReal Salt Lak |
| 28 Nov 21 | QF        | Philadelphia UnionPhiladelphia | 1 - 1 | Nashville SCNashville SC |
| 01 Dec 21 | QF        | New England Rev.New England R | 2 - 2 | New York CityNew York City |
| |
| 04 Dec 21 | SF        | Portland TimbersPortland Timb | 2 - 0 | Real Salt LakeReal Salt Lak |
| 05 Dec 21 | SF        | Philadelphia UnionPhiladelphia | 1 - 2 | New York CityNew York City |
| |
| 11 Dec 21 | Final        | Portland TimbersPortland Timb | 1 - 1 | New York CityNew York City |