| 04 Mar 18 | r01        | Philadelphia UnionPhiladelphia | 2 - 0 | New England Rev.New England R |
| 17 Mar 18 | r01        | Philadelphia UnionPhiladelphia | 0 - 0 | Columbus CrewColumbus Crew |
| 01 Apr 18 | r01        | Colorado RapidsColorado Rapi | 3 - 0 | Philadelphia UnionPhiladelphia |
| 09 Apr 18 | r01        | Philadelphia UnionPhiladelphia | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 14 Apr 18 | r01        | Philadelphia UnionPhiladelphia | 0 - 2 | Orlando CityOrlando City |
| 22 Apr 18 | r01        | FC DallasFC Dallas | 2 - 0 | Philadelphia UnionPhiladelphia |
| 28 Apr 18 | r01        | Philadelphia UnionPhiladelphia | 3 - 2 | DC UnitedDC United |
| 05 May 18 | r01        | Toronto FCToronto FC | 3 - 0 | Philadelphia UnionPhiladelphia |
| 11 May 18 | r01        | Columbus CrewColumbus Crew | 1 - 0 | Philadelphia UnionPhiladelphia |
| 12 May 18 | r01        | Montreal ImpactMontreal Impa | 0 - 2 | Philadelphia UnionPhiladelphia |
| 21 May 18 | r01        | Philadelphia UnionPhiladelphia | 4 - 1 | Real Salt LakeReal Salt Lak |
| 28 May 18 | r01        | New York Red BullsNew York Red | 0 - 0 | Philadelphia UnionPhiladelphia |
| 01 Jun 18 | r01        | Philadelphia UnionPhiladelphia | 3 - 1 | Chicago FireChicago Fire |
| 04 Jun 18 | r01        | Atlanta UnitedAtlanta Unite | 3 - 1 | Philadelphia UnionPhiladelphia |
| 09 Jun 18 | r01        | Philadelphia UnionPhiladelphia | 0 - 2 | Toronto FCToronto FC |
| 23 Jun 18 | r01        | Philadelphia UnionPhiladelphia | 4 - 0 | Vancouver WhitecapsVancouver Whi |
| 01 Jul 18 | r01        | Los Angeles FCLos Angeles F | 4 - 1 | Philadelphia UnionPhiladelphia |
| 09 Jul 18 | r01        | Philadelphia UnionPhiladelphia | 0 - 2 | Atlanta UnitedAtlanta Unite |
| 12 Jul 18 | r01        | Chicago FireChicago Fire | 3 - 4 | Philadelphia UnionPhiladelphia |
| 23 Jul 18 | r01        | Philadelphia UnionPhiladelphia | 1 - 3 | L.A. GalaxyL.A. Galaxy |
| 26 Jul 18 | r01        | Houston DynamoHouston Dynam | 1 - 3 | Philadelphia UnionPhiladelphia |
| 05 Aug 18 | r01        | Portland TimbersPortland Timb | 3 - 0 | Philadelphia UnionPhiladelphia |
| 13 Aug 18 | r01        | New England Rev.New England R | 2 - 3 | Philadelphia UnionPhiladelphia |
| 20 Aug 18 | r01        | Philadelphia UnionPhiladelphia | 2 - 0 | New York City FCNew York City |
| 27 Aug 18 | r01        | Philadelphia UnionPhiladelphia | 1 - 0 | New England Rev.New England R |
| 30 Aug 18 | r01        | DC UnitedDC United | 0 - 2 | Philadelphia UnionPhiladelphia |
| 03 Sep 18 | r01        | Orlando CityOrlando City | 2 - 2 | Philadelphia UnionPhiladelphia |
| 17 Sep 18 | r01        | Philadelphia UnionPhiladelphia | 0 - 0 | Montreal ImpactMontreal Impa |
| 20 Sep 18 | r01        | Seattle Sounders FCSeattle Sound | 0 - 0 | Philadelphia UnionPhiladelphia |
| 23 Sep 18 | r01        | Philadelphia UnionPhiladelphia | 2 - 0 | Sporting Kansas CitySporting Kans |
| 01 Oct 18 | r01        | Columbus CrewColumbus Crew | 0 - 0 | Philadelphia UnionPhiladelphia |
| 08 Oct 18 | r01        | Philadelphia UnionPhiladelphia | 5 - 1 | Minnesota UnitedMinnesota Uni |
| 21 Oct 18 | r01        | Philadelphia UnionPhiladelphia | 0 - 1 | New York Red BullsNew York Red |
| 28 Oct 18 | r01        | New York City FCNew York City | 3 - 1 | Philadelphia UnionPhiladelphia |