| 06 Mar 16 | r01        | FC DallasFC Dallas | 2 - 0 | Philadelphia UnionPhiladelphia |
| 13 Mar 16 | r01        | Columbus CrewColumbus Crew | 1 - 2 | Philadelphia UnionPhiladelphia |
| 20 Mar 16 | r01        | Philadelphia UnionPhiladelphia | 3 - 0 | New England Rev.New England R |
| 02 Apr 16 | r01        | Chicago FireChicago Fire | 1 - 0 | Philadelphia UnionPhiladelphia |
| 10 Apr 16 | r01        | Philadelphia UnionPhiladelphia | 2 - 1 | Orlando CityOrlando City |
| 17 Apr 16 | r01        | Seattle Sounders FCSeattle Sound | 2 - 1 | Philadelphia UnionPhiladelphia |
| 23 Apr 16 | r01        | Philadelphia UnionPhiladelphia | 2 - 0 | New York City FCNew York City |
| 30 Apr 16 | r01        | Philadelphia UnionPhiladelphia | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 13 May 16 | r01        | Philadelphia UnionPhiladelphia | 2 - 2 | L.A. GalaxyL.A. Galaxy |
| 22 May 16 | r01        | Philadelphia UnionPhiladelphia | 1 - 0 | DC UnitedDC United |
| 27 May 16 | r01        | Orlando CityOrlando City | 2 - 2 | Philadelphia UnionPhiladelphia |
| 29 May 16 | r01        | Colorado RapidsColorado Rapi | 1 - 1 | Philadelphia UnionPhiladelphia |
| 03 Jun 16 | r01        | Philadelphia UnionPhiladelphia | 3 - 2 | Columbus CrewColumbus Crew |
| 18 Jun 16 | r01        | New York City FCNew York City | 3 - 2 | Philadelphia UnionPhiladelphia |
| 24 Jun 16 | r01        | Philadelphia UnionPhiladelphia | 4 - 3 | Chicago FireChicago Fire |
| 27 Jun 16 | r01        | Philadelphia UnionPhiladelphia | 2 - 3 | Vancouver WhitecapsVancouver Whi |
| 03 Jul 16 | r01        | Houston DynamoHouston Dynam | 1 - 0 | Philadelphia UnionPhiladelphia |
| 11 Jul 16 | r01        | Philadelphia UnionPhiladelphia | 3 - 0 | DC UnitedDC United |
| 19 Jul 16 | r01        | Philadelphia UnionPhiladelphia | 2 - 2 | New York Red BullsNew York Red |
| 25 Jul 16 | r01        | Montreal ImpactMontreal Impa | 5 - 1 | Philadelphia UnionPhiladelphia |
| 02 Aug 16 | r01        | Philadelphia UnionPhiladelphia | 1 - 2 | Real Salt LakeReal Salt Lak |
| 08 Aug 16 | r01        | DC UnitedDC United | 2 - 2 | Philadelphia UnionPhiladelphia |
| 15 Aug 16 | r01        | New England Rev.New England R | 0 - 4 | Philadelphia UnionPhiladelphia |
| 22 Aug 16 | r01        | Philadelphia UnionPhiladelphia | 1 - 3 | Toronto FCToronto FC |
| 26 Aug 16 | r01        | Columbus CrewColumbus Crew | 1 - 2 | Philadelphia UnionPhiladelphia |
| 29 Aug 16 | r01        | Philadelphia UnionPhiladelphia | 2 - 0 | Sporting Kansas CitySporting Kans |
| 04 Sep 16 | r01        | Chicago FireChicago Fire | 3 - 0 | Philadelphia UnionPhiladelphia |
| 12 Sep 16 | r01        | Philadelphia UnionPhiladelphia | 1 - 1 | Montreal ImpactMontreal Impa |
| 17 Sep 16 | r01        | Portland TimbersPortland Timb | 2 - 1 | Philadelphia UnionPhiladelphia |
| 24 Sep 16 | r01        | Toronto FCToronto FC | 1 - 1 | Philadelphia UnionPhiladelphia |
| 03 Oct 16 | r01        | New York Red BullsNew York Red | 3 - 2 | Philadelphia UnionPhiladelphia |
| 16 Oct 16 | r01        | Philadelphia UnionPhiladelphia | 0 - 2 | Orlando CityOrlando City |
| 23 Oct 16 | r01        | Philadelphia UnionPhiladelphia | 0 - 2 | New York Red BullsNew York Red |